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G. Nepom, H. Erlich (1991)
MHC class-II molecules and autoimmunity.Annual review of immunology, 9
D. Mathis, C. Benoist, V. Williams, M. Kanter, H. Mcdevitt (1983)
The murine Eα immune response geneCell, 32
K. Bechtol, J. Freed, L. Herzenberg, H. Mcdevitt (1974)
GENETIC CONTROL OF THE ANTIBODY RESPONSE TO POLY-L(TYR,GLU)-POLY-D,L-ALA--POLY-L-LYS IN C3H↔CWB TETRAPARENTAL MICEThe Journal of Experimental Medicine, 140
Jacques Miller, G. Mitchell (1968)
CELL TO CELL INTERACTION IN THE IMMUNE RESPONSEThe Journal of Experimental Medicine, 128
H. Mcdevitt, M. Tyan (1968)
GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICEThe Journal of Experimental Medicine, 128
H. Mcdevitt (1968)
Genetic control of the antibody response. 3. Qualitative and quantitative characterization of the antibody response to (T,G)-A--L in CBA and C57 mice.Journal of immunology, 100 3
M. Sela, S. Fuchs, R. Arnon (1962)
Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine.The Biochemical journal, 85
F. Grumet, A. Coukell, J. Bodmer, W. Bodmer, H. Mcdevitt (1971)
Histocompatibility (HL-A) antigens associated with systemic lupus erythematosus. A possible genetic predisposition to disease.The New England journal of medicine, 285 4
C. Chao, H. Sytwu, E. Chen, Jon Toma, H. Mcdevitt (1999)
The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire.Proceedings of the National Academy of Sciences of the United States of America, 96 16
B. Kindred, D. Shreffler (1972)
H-2 dependence of co-operation between T and B cells in vivo.Journal of immunology, 109 5
H. Mcdevitt, W. Bodmer (1972)
Histocompatibility antigens, immune responsiveness and susceptibility to diseaseThe American Journal of Medicine, 52
J. Todd, J. Bell, H. Mcdevitt (1987)
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusNature, 329
F. Bach, M. Widmer, M. Bach, J. Klein (1972)
SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSEThe Journal of Experimental Medicine, 136
J. Lederberg (1959)
Genes and antibodies.Science, 129 3364
C. Benoist, D. Mathis, M. Kanter, V. Williams, H. Mcdevitt (1983)
Regions of allelic hypervariability in the murine Aα immune response geneCell, 34
A. Rosenthal, E. Shevach (1973)
FUNCTION OF MACROPHAGES IN ANTIGEN RECOGNITION BY GUINEA PIG T LYMPHOCYTESThe Journal of Experimental Medicine, 138
R. Goldschmidt (1941)
The material basis of evolution
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Immunological Properties of an Antibody Containing a Fluorescent Group.∗Proceedings of the Society for Experimental Biology and Medicine, 47
L. Pauling (1940)
"A Theory of the Structure and Process of Formation of Antibodies" (pages 26-32)
H. Mcdevitt, I. Green (1971)
Genetic Control of Immune Responsiveness
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Immunological SpecificityScience, 129
E. Yunis, Amos Db (1971)
Three closely linked genetic systems relevant to transplantation.Proceedings of the National Academy of Sciences of the United States of America, 68 12
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Allotype-specific analysis of anti-(TYR,GLU)-ALA-LYS antibodies produced by Ir-1A high and low responder chimeric miceThe Journal of Experimental Medicine, 146
N. Jerne (1955)
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION.Proceedings of the National Academy of Sciences of the United States of America, 41 11
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The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.Proceedings of the National Academy of Sciences of the United States of America, 84 8
H. Mcdevitt, Beverly Deak, D. Shreffler, J. Klein, J. Stimpfling, G. Snell (1972)
GENETIC CONTROL OF THE IMMUNE RESPONSEThe Journal of Experimental Medicine, 135
H. McDevitt, B. Askonas, J. Humphrey, I. Schechter, M. Sela (1966)
The localization of antigen in relation to specific antibody-producing cells. I. Use of a synthetic polypeptide [(T,G)-A--L] labelled with iodine-125.Immunology, 11 4
J. Klein (1986)
Natural history of the major histocompatibility complex
H. Mcdevitt, M. Sela (1965)
GENETIC CONTROL OF THE ANTIBODY RESPONSEThe Journal of Experimental Medicine, 122
The discovery that genes in the major histocompatibility complex (MHC) play an important role in the immune response depended on the chance interaction of several unrelated events. The first, and most important, was the decision by Michael Sela to synthesize a series of branched, multichain, synthetic polypeptides based on a backbone of poly-l-lysine. The prototype compound, (T,G)-A–L, was tipped with short random sequences of tyrosine and glutamic acid. This resulted in a restricted range of antigenic determinants composed of only two or three amino acids with a variable length—ideal for binding to the peptide binding groove of MHC class II molecules. The second was the decision by John Humphrey to immunize various strains of rabbits with this synthetic polypeptide. Two of these rabbit strains showed very large quantitative differences in antibody response to (T,G)-A–L. In transferring this system to inbred mouse strains, the third bit of good fortune was the availability at the National Institute of Medical Research, in Mill Hill (London), of the CBA (H2 k ) and C57 (H2 b ) strains. The H2 b haplotype is the only one mediating a uniform high antibody response to (T,G)-A–L. The fourth critical ingredient was the availability of numerous congenic and H2 recombinant inbred strains of mice produced earlier by Snell, Stimpfling, Shreffler, and Klein. A search for congenic pairs of mice expressing the responder and nonresponder H2 haplotypes on the same background revealed that these strains responded as a function of their H2 haplotype, not of their inbred background. Extensive studies in a variety of inbred strains carrying recombinant H2 haplotypes, as well as a four-point linkage cross, mapped immune response to (T,G)A–L within the murine MHC, between the K and Ss loci. The demonstration that stimulation in the mixed lymphocyte reaction (MLR) mapped to the same region quickly led to attempts to produce antisera in congenic H2 recombinant strain combinations. These antisera identified I-region associated (Ia) antigens. Immunoprecipitation and blocking studies showed that the gene products controlling specific immune responses, the mixed lymphocyte reaction, and the structure of Ia antigens were one and the same—now designated as the I-A MHC class II molecules. These antisera and inbred strains enabled Unanue to demonstrate the peptide binding function of class II MHC molecules.
Annual Review of Immunology – Annual Reviews
Published: Apr 1, 2000
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