Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/annual-reviews/control-of-acid-excretion-by-the-kidney-ZscsFBGW0A
References (32)
-
S. Klahr, E. Slatopolsky (1973)
Renal regulation of sodium excretion. Function in health and in edema-forming states.Archives of internal medicine, 131 6
-
D. Lowance, H. Garfinkel, W. Mattern, W. Schwartz (1972)
The effect of chronic hypotonic volume expansion on the renal regulation of acid-base equilibrium.The Journal of clinical investigation, 51 11
-
D. Levine (1971)
Effect of acute hypercapnia on proximal tubular water and bicarbonate reabsorption.The American journal of physiology, 221 4
-
A. Struyvenberg, R. Morrison, A. Relman (1968)
Acid-base behavior of separated canine renal tubule cells.The American journal of physiology, 214 5
-
F. Rector, F. Rector, Norman Carter, D. Seldin (1965)
THE MECHANISM OF BICARBONATE REABSORPTION IN THE PROXIMAL AND DISTAL TUBULES OF THE KIDNEY.The Journal of clinical investigation, 44
-
R. Tannen, J. McGill (1976)
Influence of potassium on renal ammonia production.The American journal of physiology, 231 4
-
H. Hulter, L. Ilnicki, J. Harbottle, A. Sebastian (1977)
Impaired renal H+ secretion and NH3 production in mineralocorticoid-deficient glucocorticoid-replete dogs.The American journal of physiology, 232 2
-
F. Vieira, G. Malnic (1968)
Hydrogen ion secretion by rat renal cortical tubules as studied by an antimony microelectrode.The American journal of physiology, 214 4
-
R. Tannen (1970)
The effect of uncomplicated potassium depletion on urine acidification.The Journal of clinical investigation, 49 4
-
J. Ludens, D. Fanestil (1974)
Aldosterone stimulation of acidification of urine by isolated urinary bladder of the Colombian toad.The American journal of physiology, 226 6
-
L. Frazier, J. Vanatta (1971)
Excretion of H + and NH 4 + by the urinary bladder of the acidotic toad and the effect of short-circuit current on the excretion.Biochimica et biophysica acta, 241 1
-
R. Tannen, E. Wedell, R. Moore (1973)
Renal adaptation to a high potassium intake. The role of hydrogen ion.The Journal of clinical investigation, 52 9
-
G. Giebisch, G. Malnic, G. Mello, M. Aires (1977)
Kinetics of luminal acidification in cortical tubules of the rat kidney.The Journal of Physiology, 267
-
G. Perez, J. Oster, C. Vaamonde, F. Katz (1977)
Effect of NH4Cl on plasma aldosterone, cortisol and renin activity in supine man.The Journal of clinical endocrinology and metabolism, 45 4
-
M. Burg, N. Green (1977)
Bicarbonate transport by isolated perfused rabbit proximal convoluted tubules.The American journal of physiology, 233 4
-
R. Tannen (1977)
Relationship of renal ammonia production and potassium homeostasis.Kidney international, 11 6
-
R. Tannen, H. Bleich, W. Schwartz (1966)
The renal response to acid loads in metabolic alkalosis; an assessment of the mechanisms regulating acid excretion.The Journal of clinical investigation, 45 4
-
G. Malnic, P. Steinmetz (1976)
Transport processes in urinary acidification.Kidney international, 9 2
-
A. Fine, F. Bennett, G. Alleyne (1978)
Effects of acute acid--base alterations on glutamine metabolism and renal ammoniagenesis in the dog.Clinical science and molecular medicine, 54 5
-
F. Gennari, J. Cohen (1978)
Renal tubular acidosis.Annual review of medicine, 29
-
Rui Sousa, John Harrington, Edmond Ricanati, Joel Shielkrot, William Sciwartz (1974)
Renal regulation of acid-base equilibrium during chronic administration of mineral acid.The Journal of clinical investigation, 53 2
-
M. Lucci, D. Warnock, F. Rector (1979)
Carbonic anhydrase-dependent bicarbonate reabsorption in the rat proximal tubule.The American journal of physiology, 236 1
-
T. Ziegler, J. Ludens, D. Fanestil (1974)
Role of carbonic anhydrase in urinary acidification by the toad bladder.The American journal of physiology, 227 5
-
S. Adler, A. Roy, A. Relman (1965)
INTRACELLULAR ACID-BASE REGULATION. II. THE INTERACTION BETWEEN CO-2 TENSION AND EXTRACELLULAR BICARBONATE IN THE DETERMINATION OF MUSCLE CELL PH.The Journal of clinical investigation, 44
-
Q. Al-Awqati (1978)
H + transport in urinary epithelia.The American journal of physiology, 235 2
-
T. Mckinney, M. Burg (1977)
Biocarbonate and fluid absorption by renal proximal straight tubules.Kidney international, 12 1
-
T. Mckinney, M. Burg (1978)
Bicarbonate secretion by rabbit cortical collecting tubules in vitro.The Journal of clinical investigation, 61 6
-
T. Ziegler, D. Fanestil, J. Ludens (1976)
Influence of transepithelial potential difference on acidification in the toad urinary bladder.Kidney international, 10 4
-
D. Levine (1978)
Difficulties in the micropuncture evaluation of proximal renal bicarbonate reabsorption: an overview for the general reader.Canadian journal of physiology and pharmacology, 56 3
-
T. Mckinney, M. Burg (1977)
Bicarbonate transport by rabbit cortical collecting tubules. Effect of acid and alkali loads in vivo on transport in vitro.The Journal of clinical investigation, 60 3
-
W. Schwartz, J. Cohen (1978)
The nature of the renal response to chronic disorders of acid-base equilibrium.The American journal of medicine, 64 3
-
A. Polak, G. Haynie, R. Hays, W. Schwartz (1961)
Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. I. Adaptation.The Journal of clinical investigation, 40
- Publisher
- Annual Reviews
- Copyright
- Copyright 1980 Annual Reviews. All rights reserved
- Subject
- Review Articles
- ISSN
- 0066-4219
- eISSN
- 1545-326X
- DOI
- 10.1146/annurev.me.31.020180.000343
- pmid
- 6994617
- Publisher site
- See Article on Publisher Site
Abstract
Under normal conditions the renal regulation of acid excretion is closely coupled to hydrogen ion intake, so that plasma bicarbonate concentration is maintained at stable levels despite wide variations in dietary acid inges tion. With larger hydrogen ion loads resulting from altered intake or pro duction, or with abnormalities in CO2 elimination by the lungs (respiratory acid-base disorders), renal acid excretion responds in a fashion that tends to defend the maintenance of a normal systemic pH. The renal regulation of hydrogen ion homeostasis can be viewed in terms of two distinct, yet intimately linked, processes-hydrogen ion (acid) excre tion and secretion. Acid excretion provides a renal mechanism to modify the body alkali stores. Quantitatively, acid excretion is equivalent to the sum of urinary titratable acid and ammonium, minus the bicarbonate lost in the urine. Hydrogen ion secretion includes the quantity of filtered bicar bonate reabsorbed by the nephron in addition to the amount of acid ex creted. Functionally, it determines the plasma bicarbonate concentration that can be sustained. Under normal conditions more than 98% of hydro gen ion secretion is expended in bicarbonate reabsorption, with only a minor fraction accounting for acid excretion. Despite this quantitative dis crepancy
Journal
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1980