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Comparative Biology of γδ T Cell Function in Humans, Mice, and Domestic Animals

Comparative Biology of γδ T Cell Function in Humans, Mice, and Domestic Animals γδ T cells are a functionally heterogeneous population and contribute to many early immune responses. The majority of their activity is described in humans and mice, but the immune systems of all jawed vertebrates include the γδ T cell lineage. Although some aspects of γδ T cells vary between species, critical roles in early immune responses are often conserved. Common features of γδ T cells include innate receptor expression, antigen presentation, cytotoxicity, and cytokine production. Herein we compare studies describing these conserved γδ T cell functions and other, potentially unique, functions. γδ T cells are well documented for their potential immunotherapeutic properties; however, these proposed therapies are often focused on human diseases and the mouse models thereof. This review consolidates some of these studies with those in other animals to provide a consensus for the current understanding of γδ T cell function across species. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Animal Biosciences Annual Reviews

Comparative Biology of γδ T Cell Function in Humans, Mice, and Domestic Animals

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References (184)

Publisher
Annual Reviews
Copyright
Copyright © 2013 by Annual Reviews. All rights reserved
ISSN
2165-8102
eISSN
2165-8110
DOI
10.1146/annurev-animal-031412-103639
pmid
25387013
Publisher site
See Article on Publisher Site

Abstract

γδ T cells are a functionally heterogeneous population and contribute to many early immune responses. The majority of their activity is described in humans and mice, but the immune systems of all jawed vertebrates include the γδ T cell lineage. Although some aspects of γδ T cells vary between species, critical roles in early immune responses are often conserved. Common features of γδ T cells include innate receptor expression, antigen presentation, cytotoxicity, and cytokine production. Herein we compare studies describing these conserved γδ T cell functions and other, potentially unique, functions. γδ T cells are well documented for their potential immunotherapeutic properties; however, these proposed therapies are often focused on human diseases and the mouse models thereof. This review consolidates some of these studies with those in other animals to provide a consensus for the current understanding of γδ T cell function across species.

Journal

Annual Review of Animal Biosciences – Annual Reviews

Published: Jan 1, 2013

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