C ONTROL OF A POPTOSIS IN THE I MMUNE S YSTEM : Bcl-2, BH3-Only Proteins and More

Vanessa S. Marsden; Andreas Strasser

doi:10.1146/annurev.immunol.21.120601.141029

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References (255)

Hua Zou, W. Henzel, X. Liu, Alexis Lutschg, Xiaodong Wang (1997)
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
Cell, 90
Barbara Schiemann, J. Gommerman, K. Vora, T. Cachero, Svetlana Shulga-Morskaya, M. Dobles, E. Frew, M. Scott (2001)
An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway
Science, 293
H. Puthalakath, A. Villunger, L. O’Reilly, J. Beaumont, L. Coultas, R. Cheney, D. Huang, A. Strasser (2001)
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by Anoikis
Science, 293
W. Fang, Daniel Mueller, Christopher Pennell, J. Rivard, Yue-sheng Li, Richard Hardy, M. Schlissel, Timothy Behrens (1996)
Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene.
Immunity, 4 3
D. Veis, C. Sorenson, J. Shutter, S. Korsmeyer (1993)
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
Cell, 75
A. Orlofsky, Robert Somogyi, Louis Weiss, M. Prystowsky (1999)
The murine antiapoptotic protein A1 is induced in inflammatory macrophages and constitutively expressed in neutrophils.
Journal of immunology, 163 1
Jonathan, Said, K. Chien, S. Takeuchi, T. Tasaka, H. Asou, Steve Cho, Sven de, Ethel Cesarrnan, D. Knowles, H. Koeffler (1996)
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.
Blood, 87 12
R. Hotchkiss, P. Swanson, C. Knudson, Katherine Chang, J. Cobb, D. Osborne, K. Zollner, T. Buchman, S. Korsmeyer, I. Karl (1999)
Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.
Journal of immunology, 162 7
X. Wang (2001)
The expanding role of mitochondria in apoptosis.
Genes & development, 15 22
K. Nakano, K. Vousden (2001)
PUMA, a novel proapoptotic gene, is induced by p53.
Molecular cell, 7 3
K. Kuida, J. Lippke, G. Ku, M. Harding, D. Livingston, M. Su, R. Flavell (1995)
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme.
Science, 267 5206
Stanford Peng, Marie Robert, A. Hayday, Joseph Craft (1996)
A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice
The Journal of Experimental Medicine, 184
M. Kiefer, Matthew Brauer, V. Powers, Jason Wu, S. Umansky, L. Tomei, P. Barr (1995)
Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak
Nature, 374
Barbara Cainan, Sharman Szychowski, F. Chan, D. Cado, Aster Winoto (1995)
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection.
Immunity, 3 3
F. Young, E. Mizoguchi, A. Bhan, F. Alt (1997)
Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells.
Immunity, 6 1
M. Grossmann, L. O’Reilly, R. Gugasyan, A. Strasser, Jerry Adams, S. Gerondakis (2000)
The anti‐apoptotic activities of Rel and RelA required during B‐cell maturation involve the regulation of Bcl‐2 expression
The EMBO Journal, 19
G. Hausmann, L. O’Reilly, R. Driel, J. Beaumont, A. Strasser, Jerry Adams, D. Huang (2000)
Pro-Apoptotic Apoptosis Protease–Activating Factor 1 (Apaf-1) Has a Cytoplasmic Localization Distinct from Bcl-2 or Bcl-XL
The Journal of Cell Biology, 149
D. Fulcher, A. Basten (1994)
Reduced life span of anergic self-reactive B cells in a double- transgenic model
The Journal of Experimental Medicine, 179
C. Kooten, J. Banchereau (1997)
Functions of CD40 on B cells, dendritic cells and other cells.
Current opinion in immunology, 9 3
H. Perlman, L. Pagliari, C. Georganas, T. Mano, K. Walsh, R. Pope (1999)
Flice-Inhibitory Protein Expression during Macrophage Differentiation Confers Resistance to FAS-Mediated Apoptosis
The Journal of Experimental Medicine, 190
Shulhn-Der Wang, Kuen-Jeng Huang, Y. Lin, H. Lei (1994)
Sepsis-induced apoptosis of the thymocytes in mice.
Journal of immunology, 152 10
S. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg (1997)
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Cell, 91
N. Kayagaki, Minhong Yan, D. Seshasayee, Hua Wang, Wyne Lee, D. French, I. Grewal, A. Cochran, N. Gordon, Jianping Yin, M. Starovasnik, V. Dixit (2002)
BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2.
Immunity, 17 4
A. Kuss, Matthias Knödel, F. Berberich-Siebelt, D. Lindemann, A. Schimpl, I. Berberich (1999)
A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti‐IgM‐induced cell death
European Journal of Immunology, 29
D. Vaux, S. Cory, Jerry Adams (1988)
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
Nature, 335
M. Retter, D. Nemazee (1998)
Receptor Editing Occurs Frequently during Normal B Cell Development
The Journal of Experimental Medicine, 188
T. Rothstein, Julia Wang, D. Panka, L. Foote, Zihua Wang, B. Stanger, Haili Cui, S. Ju, A. Marshak‐Rothstein (1995)
Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells
Nature, 374
A. Strasser, A. Harris, S. Cory (1993)
E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.
Oncogene, 8 1
F. Mackay, P. Schneider, P. Rennert, J. Browning (2003)
BAFF AND APRIL: a tutorial on B cell survival.
Annual review of immunology, 21
A. Vella, S. Dow, T. Potter, J. Kappler, P. Marrack (1998)
Cytokine-induced survival of activated T cells in vitro and in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 95 7
P. Björck, J. Banchereau, L. Flores-Romo (1997)
CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells.
International immunology, 9 3
M. Thome, P. Schneider, K. Hofmann, H. Fickenscher, E. Meinl, F. Neipel, C. Mattmann, K. Burns, J. Bodmer, M. Schröter, C. Scaffidi, P. Krammer, M. Peter, J. Tschopp (1997)
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
Nature, 386
Xu Luo, I. Budihardjo, Hua Zou, C. Slaughter, Xiaodong Wang (1998)
Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors
Cell, 94
C. Rubio, J. Kench, D. Russell, R. Yawger, D. Nemazee (1996)
Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes.
Journal of immunology, 157 1
Nancy Thornberry, Y. Lazebnik (1998)
Caspases: enemies within.
Science, 281 5381
P. Chuang, E. Yee, A. Karsan, R. Winn, J. Harlan (1998)
A1 is a constitutive and inducible Bcl-2 homologue in mature human neutrophils.
Biochemical and biophysical research communications, 249 2
M. Hengartner, M. Hengartner, H. Horvitz (1994)
Activation of C. elegans cell death protein CED-9 by an ammo-acid substitution in a domain conserved in Bcl-2
Nature, 369
S. Kogan, Diane Brown, D. Shultz, Bao-Tran Truong, V. Lallemand-Breitenbach, M. Guillemin, E. Lagasse, I. Weissman, J. Bishop (2001)
Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia
The Journal of Experimental Medicine, 193
S. Marsters, Minhong Yan, R. Pitti, Philip Haas, V. Dixit, A. Ashkenazi (2000)
Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
Current Biology, 10
Jianke Zhang, D. Cado, Ann Chen, N. Kabra, A. Winoto (1998)
Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
Nature, 392
Jiawei Han, C. Flemington, Anne Houghton, Z. Gu, G. Zambetti, R. Lutz, Li Zhu, T. Chittenden (2001)
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
Proceedings of the National Academy of Sciences of the United States of America, 98
Qizhong Song, Yongping Kuang, V. Dixit, C. Vincenz (1999)
Boo, a novel negative regulator of cell death, interacts with Apaf‐1
The EMBO Journal, 18
Jian Yu, Lin Zhang, P. Hwang, K. Kinzler, B. Vogelstein (2001)
PUMA induces the rapid apoptosis of colorectal cancer cells.
Molecular cell, 7 3
M. Malissen, A. Gillet, L. Ardouin, G. Bouvier, J. Trucy, P. Ferrier, É. Vivier, B. Malissen (1995)
Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene.
The EMBO Journal, 14
H. Suzuki, T. Kündig, C. Furlonger, A. Wakeham, E. Timms, T. Matsuyama, R. Schmits, J. Simard, P. Ohashi, H. Griesser (1995)
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.
Science, 268 5216
Yoshimasa Takahashi, D. Cerasoli, J. Porto, M. Shimoda, R. Freund, W. Fang, D. Telander, Erika-Nell Malvey, D. Mueller, T. Behrens, G. Kelsoe (1999)
Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in bcl-x L Transgenic Mice
The Journal of Experimental Medicine, 190
Zoltán Oltval, C. Milliman, S. Korsmeyer (1993)
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Cell, 74
E. Shores, S. Sharrow, I. Uppenkamp, A. Singer (1990)
T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway
European Journal of Immunology, 20
E. Lin, A. Orlofsky, H. Wang, John Reed, M. Prystowsky (1996)
A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.
Blood, 87 3
J. Thompson, S. Bixler, Fang Qian, K. Vora, M. Scott, T. Cachero, C. Hession, P. Schneider, I. Sizing, Colleen Mullen, K. Strauch, M. Zafari, C. Benjamin, J. Tschopp, J. Browning, C. Ambrose (2001)
BAFF-R, a Newly Identified TNF Receptor That Specifically Interacts with BAFF
Science, 293
E. Sebzda, S. Mariathasan, T. Ohteki, Russell Jones, M. Bachmann, P. Ohashi (1999)
Selection of the T cell repertoire.
Annual review of immunology, 17
K. Kuida, T. Haydar, C. Kuan, Yong Gu, C. Taya, H. Karasuyama, M. Su, P. Rakic, R. Flavell (1998)
Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Cell, 94
T. McDonnell, N. Deane, F. Platt, G. Núñez, U. Jaeger, J. Mckearn, S. Korsmeyer (1989)
bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
Cell, 57
Kenneth Smith, U. Weiss, K. Rajewsky, G. Nossal, D. Tarlinton (1994)
Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers.
Immunity, 1 9
M. Irmler, M. Thome, M. Hahne, P. Schneider, K. Hofmann, Véronique Steiner, J. Bodmer, M. Schröter, K. Burns, C. Mattmann, D. Rimoldi, L. French, J. Tschopp (1997)
Inhibition of death receptor signals by cellular FLIP
Nature, 388
I. Berberich, G. Shu, E. Clark (1994)
Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B.
Journal of immunology, 153 10
Andreas Strasser, A. Harris, H. Boehmert, Suzanne Cory (1994)
Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene.
Proceedings of the National Academy of Sciences of the United States of America, 91
S. Hsu, A. Hsueh (1998)
A Splicing Variant of the Bcl-2 Member Bok with a Truncated BH3 Domain Induces Apoptosis but Does Not Dimerize with Antiapoptotic Bcl-2 Proteins in Vitro *
The Journal of Biological Chemistry, 273
A. Strasser, A. Harris, L. Corcoran, S. Cory (1994)
Bcl-2 expression promotes B- but not T-lymphoid development in scid mice
Nature, 368
S. Susin, H. Lorenzo, N. Zamzami, I. Marzo, B. Snow, G. Brothers, J. Mangion, E. Jacotot, P. Costantini, M. Loeffler, N. Larochette, D. Goodlett, R. Aebersold, D. Siderovski, J. Penninger, G. Kroemer (1999)
Molecular characterization of mitochondrial apoptosis-inducing factor
Nature, 397
J. Rathmell, C. Goodnow (1994)
Effects of the lpr mutation on elimination and inactivation of self-reactive B cells.
Journal of immunology, 153 6
G. Putcha, Charles Harris, K. Moulder, R. Easton, C. Thompson, Eugene Johnson (2002)
Intrinsic and extrinsic pathway signaling during neuronal apoptosis
The Journal of Cell Biology, 157
Corinne Tanchot, F. Lemonnier, B. Pérarnau, A. Freitas, B. Rocha (1997)
Differential requirements for survival and proliferation of CD8 naïve or memory T cells.
Science, 276 5321
J. Rathmell, M. Cooke, W. Ho, J. Grein, S. Townsend, Mark Davis, C. Goodnow (1995)
CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells
Nature, 376
Eri Oda, Rieko Ohki, H. Murasawa, J. Nemoto, T. Shibue, T. Yamashita, T. Tokino, T. Taniguchi, N. Tanaka (2000)
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.
Science, 288 5468
M. Muzio, A. Chinnaiyan, F. Kischkel, K. O’Rourke, A. Shevchenko, J. Ni, C. Scaffidi, J. Bretz, Mei Zhang, R. Gentz, M. Mann, P. Krammer, M. Peter, V. Dixit (1996)
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
Cell, 85
P. Bouillet, S. Cory, Li-Chen Zhang, A. Strasser, Jerry Adams (2001)
Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.
Developmental cell, 1 5
P. Epling-Burnette, B. Zhong, Fanqi Bai, K. Jiang, R. Bailey, R. Garcia, R. Jove, J. Djeu, T. Loughran, Sheng Wei (2001)
Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils1
The Journal of Immunology, 166
K. Zimmermann, J. Ricci, N. Droin, D. Green (2002)
The role of ARK in stress-induced apoptosis in Drosophila cells
The Journal of Cell Biology, 156
Jin Wang, A. Lobito, Fan Shen, F. Hornung, A. Winoto, M. Lenardo (2000)
Inhibition of Fas‐mediated apoptosis by the B cell antigen receptor through c‐FLIP
European Journal of Immunology, 30
C. Beltinger, Elke Kurz, T. Böhler, M. Schrappe, W. Ludwig, K. Debatin (1998)
CD95 (APO-1/Fas) mutations in childhood T-lineage acute lymphoblastic leukemia.
Blood, 91 10
A. Rolink, Christoph Schaniel, Jan Andersson, F. Melchers (2001)
Selection events operating at various stages in B cell development.
Current opinion in immunology, 13 2
S. Tiegs, D. Russell, D. Nemazee (1993)
Receptor editing in self-reactive bone marrow B cells
The Journal of Experimental Medicine, 177
Ellis Re, Junying Yuan, Horvitz Hr (1991)
Mechanisms and functions of cell death.
Annual review of cell biology, 7
K. Imaizumi, M. Tsuda, Y. Imai, A. Wanaka, T. Takagi, M. Tohyama (1997)
Molecular Cloning of a Novel Polypeptide, DP5, Induced during Programmed Neuronal Death*
The Journal of Biological Chemistry, 272
Tomohiro Takahashi, Masato Tanaka, C. Brannan, N. Jenkins, N. Copeland, T. Suda, S. Nagata (1994)
Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand
Cell, 76
A. Verhagen, E. Coulson, D. Vaux (2001)
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
Genome Biology, 2
P. Schneider, F. Mackay, Véronique Steiner, K. Hofmann, J. Bodmer, N. Holler, C. Ambrose, P. Lawton, S. Bixler, H. Acha-Orbea, D. Valmori, P. Romero, C. Werner‐Favre, R. Zubler, J. Browning, J. Tschopp (1999)
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
The Journal of Experimental Medicine, 189
D. Nicholson (1999)
Caspase structure, proteolytic substrates, and function during apoptotic cell death
Cell Death and Differentiation, 6
K. Lam, R. Kühn, K. Rajewsky (1997)
In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death
Cell, 90
D. Witherden, N. Oers, N. Oers, C. Waltzinger, A. Weiss, C. Benoist, D. Mathis (2000)
Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules.
The Journal of experimental medicine, 191 2
W. Schuler, I. Weiler, A. Schuler, R. Phillips, N. Rosenberg, T. Mak, J. Kearney, R. Perry, M. Bosma (1986)
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency
Cell, 46
D. Tarlinton, L. Corcoran, A. Strasser (1997)
Continued differentiation during B lymphopoiesis requires signals in addition to cell survival.
International immunology, 9 10
E. Maraskovsky, M. Teepe, P. Morrissey, S. Braddy, Robert Miller, David Lynch, J. Peschon (1996)
Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells.
Journal of immunology, 157 12
D. Vaux, A. Strasser (1996)
The molecular biology of apoptosis.
Proceedings of the National Academy of Sciences of the United States of America, 93 6
Y. Laâbi, A. Egle, A. Strasser (2001)
TNF cytokine family: More BAFF-ling complexities
Current Biology, 11
K. Newton, A. Harris, M. Bath, Kenneth Smith, A. Strasser (1998)
A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
The EMBO Journal, 17
A. Strasser, A. Harris, M. Bath, S. Cory (1990)
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
Nature, 348
Laurence Turka, David Schatz, M. Oettinger, Jerold Chun, Carolyn Gorka, Kelvin Lee, Wayne McCormack, Craig Thompson (1991)
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
Science, 253 5021
N. Inohara, D. Ekhterae, Irène Garcia, R. Carrio, J. Merino, A. Merry, Shu Chen, G. Núñez (1998)
Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL *
The Journal of Biological Chemistry, 273
T. Nakagawa, Hong Zhu, N. Morishima, En Li, Jin Xu, B. Yankner, Junying Yuan (2000)
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
Nature, 403
Kenneth Smith, A. Light, G. Nossal, D. Tarlinton (1997)
The extent of affinity maturation differs between the memory and antibody‐forming cell compartments in the primary immune response
The EMBO Journal, 16
P. Bouillet, D. Metcalf, D. Huang, D. Tarlinton, T. Kay, Frank Koentgen, J. Adams, A. Strasser (1999)
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.
Science, 286 5445
G. Zauli, D. Gibellini, A. Caputo, A. Bassini, M. Negrini, M. Monne, M. Mazzoni, S. Capitani (1995)
The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.
Blood, 86 10
B. Guo, A. Godzik, John Reed (2001)
Bcl-G, a Novel Pro-apoptotic Member of the Bcl-2 Family*
The Journal of Biological Chemistry, 276
E. Varfolomeev, Marcus Schuchmann, V. Luria, N. Chiannilkulchai, Jacques Beckmann, I. Mett, Denis Rebrikov, V. Brodianski, O. Kemper, O. Kollet, T. Lapidot, Dror Soffer, T. Sobe, K. Avraham, T. Goncharov, H. Holtmann, P. Lonai, D. Wallach (1998)
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.
Immunity, 9 2
D. Traver, K. Akashi, I. Weissman, E. Lagasse (1998)
Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia.
Immunity, 9 1
Vanessa Marsden, L. O’Connor, L. O’Reilly, J. Silke, D. Metcalf, P. Ekert, D. Huang, F. Cecconi, K. Kuida, K. Tomaselli, Sophie Roy, D. Nicholson, D. Vaux, P. Bouillet, Jerry Adams, A. Strasser (2002)
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Nature, 419
F. Rieux-Laucat, F. Deist, C. Hivroz, I. Roberts, K. Debatin, A. Fischer, J. Villartay (1995)
Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.
Science, 268 5215
D. Ashany, Xin Song, Elizabeth Lacy, J. Nikolić-Žugić, Steven Friedman, Keith Elkon (1995)
Th1 CD4+ lymphocytes delete activated macrophages through the Fas/APO-1 antigen pathway.
Proceedings of the National Academy of Sciences of the United States of America, 92 24
J. Savill, V. Fadok (2000)
Corpse clearance defines the meaning of cell death
Nature, 407
M. Hengartner (2000)
The biochemistry of apoptosis
Nature, 407
Minhong Yan, J. Brady, B. Chan, Wyne Lee, Benjamin Hsu, Susan Harless, M. Cancro, I. Grewal, V. Dixit (2001)
Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency
Current Biology, 11
G. Buchman, Irene Karl, F. Osborne, Bradley Freeman, J. Cobb, Timothy, R. Schmieg, Jia Hui, Katherine Chang, Dale, R. Hotchkiss, K. Tinsley, Paul Swanson (2001)
Sepsis-Induced Apoptosis Causes Progressive Profound Depletion of B and CD4+ T Lymphocytes in Humans1
The Journal of Immunology, 166
H. Harada, B. Becknell, M. Wilm, M. Mann, L. Huang, Susan Taylor, J. Scott, S. Korsmeyer, S. Korsmeyer (1999)
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A.
Molecular cell, 3 4
Yunji Park, Seung Lee, Y. Sung (2002)
Cutting Edge: CpG DNA Inhibits Dendritic Cell Apoptosis by Up-Regulating Cellular Inhibitor of Apoptosis Proteins Through the Phosphatidylinositide-3′-OH Kinase Pathway1
The Journal of Immunology, 168
K. Nakayama, K. Nakayama, I. Negishi, K. Kuida, H. Sawa, D. Loh (1994)
Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.
Proceedings of the National Academy of Sciences of the United States of America, 91 9
T. Teague, P. Marrack, J. Kappler, A. Vella (1997)
IL-6 rescues resting mouse T cells from apoptosis.
Journal of immunology, 158 12
John Kerr, A. Wyllie, R. Alastair, Currie (1972)
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
British Journal of Cancer, 26
A. Wyllie, J. Kerr, A. Currie (1980)
Cell death: the significance of apoptosis.
International review of cytology, 68
Z. Xiang, A. Ahmed, C. Möller, K. Nakayama, S. Hatakeyama, G. Nilsson (2001)
Essential Role of the Prosurvival bcl-2 Homologue A1 in Mast Cell Survival After Allergic Activation
The Journal of Experimental Medicine, 194
K. Lam, K. Rajewsky (1998)
Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 95 22
M. Hahne, T. Kataoka, M. Schröter, K. Hofmann, M. Irmler, J. Bodmer, P. Schneider, T. Bornand, N. Holler, L. French, B. Sordat, D. Rimoldi, J. Tschopp (1998)
APRIL, a New Ligand of the Tumor Necrosis Factor Family, Stimulates Tumor Cell Growth
The Journal of Experimental Medicine, 188
L. Peso, M. González‐García, C. Page, R. Herrera, G. Núñez (1997)
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.
Science, 278 5338
B. Bochner, R. Schleimer (2001)
Mast cells, basophils, and eosinophils: distinct but overlapping pathways for recruitment
Immunological Reviews, 179
A. Tamura, M. Katsumata, M. Greene, K. Yui (1996)
Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice.
Cellular immunology, 168 2
X. Li, G. Demirci, S. Ferrari-Lacraz, C. Groves, A. Coyle, T. Malek, T. Strom (2001)
IL-15 and IL-2: a matter of life and death for T cells in vivo
Nature Medicine, 7
B. Conradt, H. Horvitz (1999)
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
Cell, 98
H. Petrie, F. Livak, D. Schatz, A. Strasser, I. Crispe, K. Shortman (1993)
Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes
The Journal of Experimental Medicine, 178
F. Mollinedo, N. Borregaard, L. Boxer (1999)
Novel trends in neutrophil structure, function and development.
Immunology today, 20 12
S. Takeda, H. Rodewald, H. Arakawa, H. Bluethmann, Takeyuki Shimizu (1996)
MHC class II molecules are not required for survival of newly generated CD4+ T cells, but affect their long-term life span.
Immunity, 5 3
K. Kuida, T. Zheng, S. Na, C. Kuan, Di Yang, H. Karasuyama, P. Rakic, R. Flavell (1996)
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
Nature, 384
J. Lang, B. Arnold, G. Hammerling, A. Harris, S. Korsmeyer, D. Russell, A. Strasser, David Nemazee, David Nemazee (1997)
Enforced Bcl-2 Expression Inhibits Antigen-mediated Clonal Elimination of Peripheral B Cells in an Antigen Dose–dependent Manner and Promotes Receptor Editing in Autoreactive, Immature B Cells
The Journal of Experimental Medicine, 186
H. Schorle, Thomas Holtschke, T. Hünig, A. Schimpl, I. Horak (1991)
Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
Nature, 352
L. Boise, M. González‐García, C. Postema, Liyun Ding, T. Lindsten, L. Turka, X. Mao, G. Núñez, C. Thompson (1993)
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
Cell, 74
D. Tarlinton (1998)
Germinal centers: form and function.
Current opinion in immunology, 10 3
D. Metcalf (1997)
The molecular control of granulocytes and macrophages.
Ciba Foundation symposium, 204
David Hildeman, Yanan Zhu, T. Mitchell, P. Bouillet, A. Strasser, J. Kappler, P. Marrack (2002)
Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.
Immunity, 16 6
Minhong Yan, S. Marsters, I. Grewal, Hua Wang, A. Ashkenazi, V. Dixit (2000)
Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity
Nature Immunology, 1
D. Huang, M. Hahne, M. Schroeter, K. Frei, A. Fontana, A. Villunger, K. Newton, J. Tschopp, A. Strasser (1999)
Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x(L).
Proceedings of the National Academy of Sciences of the United States of America, 96 26
Yin Guo, S. Srinivasula, A. Druilhe, T. Fernandes‐Alnemri, E. Alnemri (2002)
Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria*
The Journal of Biological Chemistry, 277
L. Bergeron, G. Perez, G. Macdonald, Lianfa Shi, Yi Sun, A. Jurisicova, S. Varmuza, K. Latham, J. Flaws, Jessica Salter, H. Hara, M. Moskowitz, En Li, A. Greenberg, J. Tilly, Junying Yuan (1998)
Defects in regulation of apoptosis in caspase-2-deficient mice.
Genes & development, 12 9
D. Melamed, R. Benschop, J. Cambier, D. Nemazee (1998)
Developmental Regulation of B Lymphocyte Immune Tolerance Compartmentalizes Clonal Selection from Receptor Selection
Cell, 92
Takashi Suda, Masato Tanaka, Masato Tanaka, Keiko Miwa, Shigekazu Nagata (1996)
Apoptosis of mouse naive T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand.
Journal of immunology, 157 9
J. Yuan, H. Horvitz (1990)
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death.
Developmental biology, 138 1
Motoshi Suzuki, R. Youle, N. Tjandra (2000)
Structure of Bax Coregulation of Dimer Formation and Intracellular Localization
Cell, 103
E. Cheng, J. Nicholas, D. Bellows, G. Hayward, Hong Guo, Marvin Reitz, J. Hardwick (1997)
A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak.
Proceedings of the National Academy of Sciences of the United States of America, 94 2
R. Hardy, K. Hayakawa (2001)
B cell development pathways.
Annual review of immunology, 19
M. Batten, J. Groom, T. Cachero, Fang Qian, P. Schneider, J. Tschopp, J. Browning, F. Mackay (2000)
Baff Mediates Survival of Peripheral Immature B Lymphocytes
The Journal of Experimental Medicine, 192
Philip Morrissey, K. Grabstein, Fred Ramsde, Eugene Maraskovsky, Brian Gliniak, Linda Park, Steven Ziegler, Doughs Williams, Carol Ware, Jeff Meyer, Barry Davison (1994)
Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
The Journal of Experimental Medicine, 180
D. Ashany, A. Savir, N. Bhardwaj, K. Elkon (1999)
Dendritic cells are resistant to apoptosis through the Fas (CD95/APO-1) pathway.
Journal of immunology, 163 10
S. Tamiya, K. Etoh, H. Suzushima, K. Takatsuki, M. Matsuoka (1998)
Mutation of CD95 (Fas/Apo-1) Gene in Adult T-Cell Leukemia Cells
Blood, 91
A. Suzuki, A. Suzuki, A. Suzuki, Manae Yamaguchi, T. Ohteki, Takehiko Sasaki, T. Kaisho, Yuki Kimura, Ritsuko Yoshida, A. Wakeham, Tetsuya Higuchi, M. Fukumoto, T. Tsubata, P. Ohashi, S. Koyasu, J. Penninger, T. Nakano, T. Mak (2001)
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Immunity, 14 5
N. Motoyama, F. Wang, K. Roth, H. Sawa, K. Nakayama, I. Negishi, S. Senju, Q. Zhang, S. Fujii, al. et (1995)
Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice
Science, 267
M. Kondo, K. Akashi, J. Domen, K. Sugamura, I. Weissman (1997)
Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice
Immunity, 7
P. Lassus, Ximena Opitz-Araya, Y. Lazebnik (2002)
Requirement for Caspase-2 in Stress-Induced Apoptosis Before Mitochondrial Permeabilization
Science, 297
N. Ke, A. Godzik, John Reed (2001)
Bcl-B, a Novel Bcl-2 Family Member That Differentially Binds and Regulates Bax and Bak*
The Journal of Biological Chemistry, 276
A. Villunger, L. O’Reilly, N. Holler, Jerry Adams, A. Strasser (2000)
FAS Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-Activated Protein Kinase
The Journal of Experimental Medicine, 192
Ursula Freeden-Jeffry, P. Vieira, L. Lucian, T. McNeil, Stefan Burdach, R. Murray (1995)
Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
The Journal of Experimental Medicine, 181
P. Mombaerts, A. Clarke, M. Rudnicki, J. Iacomini, S. Itohara, J. Lafaille, Lili Wang, Y. Ichikawa, R. Jaenisch, M. Hooper, S. Tonegawa (1992)
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Nature, 360
W. Yeh, J. Pompa, M. Mccurrach, H. Shu, A. Elia, A. Shahinian, M. Ng, A. Wakeham, W. Khoo, K. Mitchell, W. El-Deiry, S. Lowe, D. Goeddel, T. Mak (1998)
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis.
Science, 279 5358
P. Cohen, R. Eisenberg (1991)
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease.
Annual review of immunology, 9
T. Kurosaki (1999)
Genetic analysis of B cell antigen receptor signaling.
Annual review of immunology, 17
K. Newton, A. Harris, A. Strasser (2000)
FADD/MORT1 regulates the pre‐TCR checkpoint and can function as a tumour suppressor
The EMBO Journal, 19
F. Kischkel, S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P. Krammer, M. Peter (1995)
Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.
The EMBO Journal, 14
Lily Li, Xu Luo, Xiaodong Wang (2001)
Endonuclease G is an apoptotic DNase when released from mitochondria
Nature, 412
A. Hamasaki, F. Sendo, Kei-ichi Nakayama, N. Ishida, I. Negishi, Kei-ichi Nakayama, S. Hatakeyama (1998)
Accelerated Neutrophil Apoptosis in Mice Lacking A1-a, a Subtype of the bcl-2–related A1 Gene
The Journal of Experimental Medicine, 188
J. Boyd, G. Gallo, B. Elangovan, A. Houghton, S. Malstrom, B. Avery, R. Ebb, T. Subramanian, T. Chittenden, R. Lutz (1995)
Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.
Oncogene, 11 9
G. Alderson, T. Tough, T. Davis‐Smith, Steve Braddy, Ben Falk, Ken Schooley, Raymond Goodwin, Craig Smith, Fred Ramsdell, David Lynch (1995)
Fas ligand mediates activation-induced cell death in human T lymphocytes
The Journal of Experimental Medicine, 181
M. Groettrup, H. Boehmer (1993)
A role for a pre-T-cell receptor in T-cell development.
Immunology today, 14 12
K. Fecho, S. Bentley, P. Cohen (1998)
Mice deficient in fas ligand (gld) or fas (lpr) show few alterations in granulopoiesis.
Cellular immunology, 188 1
S. Choi, I. Park, J. Yun, Y. Sung, S. Hong, H. Shin (1995)
A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.
Oncogene, 11 9
F. Melchers, H. Karasuyama, D. Haasner, S. Bauer, A. Kudo, N. Sakaguchi, B. Jameson, A. Rolink (1993)
The surrogate light chain in B-cell development.
Immunology today, 14 2
S. Henderson, D. Huen, M. Rowe, C. Dawson, G. JOHNSONt, A. Rickinson (1993)
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.
Proceedings of the National Academy of Sciences of the United States of America, 90 18
T. Brunner, R. Mogil, D. Laface, N. Yoo, A. Mahboubi, F. Echeverri, Seamus Martin, W. Force, D. Lynch, C. Ware, D. Green (1995)
Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
Nature, 373
Russell Jones, Michael Parsons, M. Bonnard, V. Chan, W. Yeh, J. Woodgett, P. Ohashi (2000)
Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo
The Journal of Experimental Medicine, 191
L. O’Connor, A. Strasser, L. O’Reilly, G. Hausmann, Jerry Adams, S. Cory, D. Huang (1998)
Bim: a novel member of the Bcl‐2 family that promotes apoptosis
The EMBO Journal, 17
N. Inohara, Liyun Ding, Shu Chen, G. Núñez (1997)
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival‐promoting proteins Bcl‐2 and Bcl‐XL
The EMBO Journal, 16
Rie Watanabe‐Fukunaga, C. Brannan, N. Copeland, N. Jenkins, S. Nagata (1992)
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Nature, 356
T. Sparwasser, R. Vabulas, Brigitte Villmow, G. Lipford, H. Wagner (2000)
Bacterial CpG‐DNA activates dendritic cells in vivo: T helper cell‐independent cytotoxic T cell responses to soluble proteins
European Journal of Immunology, 30
C. Tepper, M. Seldin (1999)
Modulation of caspase-8 and FLICE-inhibitory protein expression as a potential mechanism of Epstein-Barr virus tumorigenesis in Burkitt's lymphoma.
Blood, 94 5
J. Zha, H. Harada, E. Yang, J. Jockel, S. Korsmeyer (1996)
Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL
Cell, 87
J. Dhein, H. Walczak, C. Bäumler, K. Debatin, P. Krammer (1995)
Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
Nature, 373
D. Green, John Reed (1998)
Mitochondria and apoptosis.
Science, 281 5381
M. Boldin, T. Goncharov, Yury Goltseve, D. Wallach (1996)
Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death
Cell, 85
Kun Wang, X. Yin, D. Chao, C. Milliman, S. Korsmeyer (1996)
BID: a novel BH3 domain-only death agonist.
Genes & development, 10 22
D. Jiang, M. Lenardo, J. Zúñiga-Pflücker (1996)
p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement
The Journal of Experimental Medicine, 183
Malgorzata Nieborowska‐Skorska, G. Hoser, P. Kossev, M. Wasik, T. Skorski (2002)
Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis.
Blood, 99 12
S. Farrow, Julia White, I. Martinou, T. Raven, K. Pun, C. Grinham, J. Martinou, Robin Brown (1995)
Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
Nature, 374
Y. Shinkai, 0Gary Rathbun, K. Lam, E. Oltz, V. Stewart, Monica Mendelsohn, J. Charron, M. Datta, F. Young, A. Stall, F. Alt (1992)
RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
Cell, 68
Takao Kataoka, M. Schröter, Michael Hahne, Pascal Schneider, Martin Irmler, M. Thome, Cristopher Froelich, Jürg Tschopp (1998)
FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation.
Journal of immunology, 161 8
Dale Moulding, J. Quayle, C. Hart, Steven Edwards (1998)
Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival
Blood, 92
Honglin Li, Hong Zhu, Chi-jie Xu, Junying Yuan (1998)
Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
Cell, 94
E. Cheng, M. Wei, S. Weiler, R. Flavell, T. Mak, T. Lindsten, S. Korsmeyer (2001)
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis.
Molecular cell, 8 3
T. Zheng, S. Hunot, K. Kuida, R. Flavell (1999)
Caspase knockouts: matters of life and death
Cell Death and Differentiation, 6
R. Sarid, Takaaki Sato, R. Bohenzky, J. Russo, Yuan Chang (1997)
Kaposi's sarcoma-associated herpesvirus encodes a functional Bcl-2 homologue
Nature Medicine, 3
M. Stürzl, C. Hohenadl, C. Zietz, E. Castaños-Vélez, Anneliese Wunderlich, G. Ascherl, P. Biberfeld, P. Monini, P. Browning, B. Ensoli (1999)
Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells.
Journal of the National Cancer Institute, 91 20
G. Salvesen, V. Dixit (1999)
Caspase activation: the induced-proximity model.
Proceedings of the National Academy of Sciences of the United States of America, 96 20
T. Chittenden, E. Harrington, R. O’Connor, C. Remington, R. Lutz, G. Evan, B. Guild (1995)
Induction of apoptosis by the Bcl-2 homologue Bak
Nature, 374
E. Maraskovsky, L. O’Reilly, M. Teepe, L. Corcoran, J. Peschon, A. Strasser (1997)
Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice
Cell, 89
Kenneth Smith, A. Light, L. O’Reilly, Soon-Meng Ang, A. Strasser, D. Tarlinton (2000)
bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells
The Journal of Experimental Medicine, 191
T. Zhou, Jianhua Cheng, Pingar Yang, Zheng Wang, Changdan Liu, X. Su, H. Bluethmann, J. Mountz (1996)
Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self- reactive T cells
The Journal of Experimental Medicine, 183
J. Russell, B. Rush, C. Weaver, Ruduan Wang (1993)
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.
Proceedings of the National Academy of Sciences of the United States of America, 90
P. Moore, O. Belvedere, Amy Orr, Krystyna Pieri, D. LaFleur, P. Feng, D. Soppet, Meghan Charters, Reiner Gentz, D. Parmelee, Yuling Li, O. Galperina, J. Giri, V. Roschke, B. Nardelli, J. Carrell, S. Sosnovtseva, W. Greenfield, S. Ruben, H. Olsen, J. Fikes, D. Hilbert (1999)
BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator.
Science, 285 5425
Y. Refaeli, L. Parijs, Cheryl London, J. Tschopp, Abul Abbas (1998)
Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
Immunity, 8 5
Yoshiko Nishimura, A. Ishii, Y. Kobayashi, Yoshiki Yamasaki, S. Yonehara (1995)
Expression and function of mouse Fas antigen on immature and mature T cells.
Journal of immunology, 154 9
Y. Laâbi, A. Strasser (2000)
Lymphocyte Survival--Ignorance Is BLys
Science, 289
T. Lindsten, Andrea Ross, Ayala King, W. Zong, J. Rathmell, Helena Shiels, E. Ulrich, K. Waymire, Patryce Mahar, K. Frauwirth, Yifeng Chen, M. Wei, Vicki Eng, David Adelman, M. Simon, A. Ma, Jeffrey Golden, G. Evan, S. Korsmeyer, Grant MacGregor, Craig Thompson (2000)
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.
Molecular cell, 6 6
N. Inohara, T. Gourley, R. Carrio, Maria Muñiz, J. Merino, Irène Garcia, T. Koseki, Yuanming Hu, Shu Chen, G. Núñez (1998)
Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death*
The Journal of Biological Chemistry, 273
S. Ogilvy, D. Metcalf, C. Print, M. Bath, A. Harris, Jerry Adams (1999)
Constitutive Bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival.
Proceedings of the National Academy of Sciences of the United States of America, 96 26
Y. Tsujimoto, C. Croce (1986)
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
Proceedings of the National Academy of Sciences of the United States of America, 83 14
A. Strasser, S. Whittingham, D. Vaux, M. Bath, Jerry Adams, S. Cory, A. Harris (1991)
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America, 88 19
P. Bouillet, J. Purton, D. Godfrey, Li-Chen Zhang, L. Coultas, H. Puthalakath, M. Pellegrini, S. Cory, Jerry Adams, A. Strasser (2002)
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
Nature, 415
Jerry Adams, S. Cory (1998)
The Bcl-2 protein family: arbiters of cell survival.
Science, 281 5381
Eugene Maraskovsky, J. Peschon, Hilary Mckenna, M. Teepe, Andreas Strasser (1998)
Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells.
International immunology, 10 9
C. Guidos, Christine Williams, Ildiko Grandal, G. Knowles, M. Huang, J. Danska (1996)
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
Genes & development, 10 16
P. Blume-Jensen, R. Janknecht, T. Hunter (1998)
The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
Current Biology, 8
H. Puthalakath, A. Strasser (2002)
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
Cell Death and Differentiation, 9
A. Dang-Vu, D. Pisetsky, J. Weinberg (1987)
Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice.
Journal of immunology, 138 6
R. Hegde, S. Srinivasula, Manzoor Ahmad, T. Fernandes‐Alnemri, E. Alnemri (1998)
Blk, a BH3-containing Mouse Protein That Interacts with Bcl-2 and Bcl-xL, Is a Potent Death Agonist*
The Journal of Biological Chemistry, 273
D. Nemazee (2000)
Receptor selection in B and T lymphocytes.
Annual review of immunology, 18
A. Strasser, A. Harris, S. Cory (1991)
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
Cell, 67
T. Groves, M. Parsons, N. Miyamoto, C. Guidos (1997)
TCR engagement of CD4+CD8+ thymocytes in vitro induces early aspects of positive selection, but not apoptosis.
Journal of immunology, 158 1
Kenneth Smith, G. Nossal, D. Tarlinton, D. Tarlinton, D. Tarlinton (1995)
FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen.
Proceedings of the National Academy of Sciences of the United States of America, 92 25
P. Mombaerts, J. Iacomini, R. Johnson, K. Herrup, S. Tonegawa, V. Papaioannou (1992)
RAG-1-deficient mice have no mature B and T lymphocytes
Cell, 68
W. Davidson, T. Giese, T. Fredrickson (1998)
Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions
The Journal of Experimental Medicine, 187
T. Lithgow, T. Lithgow, R. Driel, J. Bertram, A. Strasser (1994)
The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 5 4
R. Do, E. Hatada, Hayyoung Lee, M. Tourigny, D. Hilbert, S. Chen‐Kiang (2000)
Attenuation of Apoptosis Underlies B Lymphocyte Stimulator Enhancement of Humoral Immune Response
The Journal of Experimental Medicine, 192
Yumi Matsuzaki, Keiichi Nakayama, Keiko Nakayama, Takashi Tomita, Miu Isoda, Dennis Loh, Hiromitsu Nakauchi (1997)
Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell.
Blood, 89 3
J. Banchereau, F. Brière, C. Caux, J. Davoust, S. Lebecque, Yong‐jun Liu, B. Pulendran, K. Palucka (2000)
Immunobiology of dendritic cells.
Annual review of immunology, 18
S. Ju, D. Panka, Haili Cui, R. Ettinger, Maan EI-Khatib, D. Sherr, B. Stanger, A. Marshak‐Rothstein (1995)
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
Nature, 373
R. Duke, J. Cohen (1986)
IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.
Lymphokine research, 5 4
Wei Fang, Bennett Weintraub, Brenda Dunlap, Paul Garside, Kathy Pape, Marc Jenkins, Christopher Goodnow, Daniel Mueller, Timothy Behrens (1998)
Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing.
Immunity, 9 1
Suyue Wang, M. Miura, Yong-Keun Jung, Hong Zhu, En Li, Junying Yuan (1998)
Murine Caspase-11, an ICE-Interacting Protease, Is Essential for the Activation of ICE
Cell, 92
A. Chinnaiyan, K. O’Rourke, M. Tewari, V. Dixit (1995)
FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis
Cell, 81
Jun Ogasawara, Takashi Suda, Shigekazu Nagata (1995)
Selective apoptosis of CD4+CD8+ thymocytes by the anti-Fas antibody
The Journal of Experimental Medicine, 181
N. Kabra, Chulho Kang, L. Hsing, Jianke Zhang, A. Winoto (2001)
T cell-specific FADD-deficient mice: FADD is required for early T cell development
Proceedings of the National Academy of Sciences of the United States of America, 98
A. Gross, J. McDonnell, S. Korsmeyer (1999)
BCL-2 family members and the mitochondria in apoptosis.
Genes & development, 13 15
B. Wong, R. Josien, Soo Lee, B. Sauter, Hong‐li Li, R. Steinman, Yongwon Choi (1997)
TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor
The Journal of Experimental Medicine, 186
R. Hakem, A. Hakem, G. Duncan, J. Henderson, M. Woo, M. Soengas, A. Elia, J. Pompa, D. Kagi, W. Khoo, J. Potter, Ritsuko Yoshida, S. Kaufman, S. Lowe, J. Penninger, T. Mak (1998)
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Cell, 94
A. Strasser, A. Harris, D. Huang, P. Krammer, S. Cory (1995)
Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
The EMBO Journal, 14
J. Kirberg, A. Berns, H. Boehmer (1997)
Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules
The Journal of Experimental Medicine, 186
K. Kozopas, Tao Yang, H. Buchan, Ping Zhou, R. Craig (1993)
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
Proceedings of the National Academy of Sciences of the United States of America, 90
D. Acton, J. Domen, H. Jacobs, M. Vlaar, S. Korsmeyer, A. Berns (1992)
Collaboration of pim-1 and bcl-2 in lymphomagenesis.
Current topics in microbiology and immunology, 182
A. Krueger, I. Schmitz, S. Baumann, P. Krammer, S. Kirchhoff (2001)
Cellular FLICE-inhibitory Protein Splice Variants Inhibit Different Steps of Caspase-8 Activation at the CD95 Death-inducing Signaling Complex*
The Journal of Biological Chemistry, 276
S. Hartley, M. Cooke, D. Fulcher, A. Harris, S. Cory, A. Basten, C. Goodnow (1993)
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
Cell, 72
W. Zong, T. Lindsten, Andrea Ross, G. MacGregor, C. Thompson (2001)
BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak.
Genes & development, 15 12
A. Vella, T. Teague, J. Ihle, J. Kappler, P. Marrack (1997)
Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4
The Journal of Experimental Medicine, 186
L. Gibson, S. Holmgreen, D. Huang, O. Bernard, N. Copeland, N. Jenkins, G. Sutherland, E. Baker, Jerry Adams, S. Cory (1996)
bcl-w, a novel member of the bcl-2 family, promotes cell survival.
Oncogene, 13 4
M. Bogue, Chengming Zhu, E. Aguilar‐Cordova, L. Donehower, D. Roth (1996)
p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes.
Genes & development, 10 5
Kenneth Smith, A. Strasser, D. Vaux (1996)
CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO‐1)‐transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.
The EMBO Journal, 15
D. Huang, A. Strasser (2000)
BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death
Cell, 103
L. Dorstyn, S. Read, Dimitrios Cakouros, Jun Huh, B. Hay, Sharad Kumar (2002)
The role of cytochrome c in caspase activation in Drosophila melanogaster cells
The Journal of Cell Biology, 156
C. Sentman, J. Shutter, D. Hockenbery, O. Kanagawa, S. Korsmeyer (1991)
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
Cell, 67
H. Puthalakath, D. Huang, L. O’Reilly, S. King, A. Strasser (1999)
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.
Molecular cell, 3 3
E. Yang, J. Zha, J. Jockel, L. Boise, C. Thompson, S. Korsmeyer (1995)
Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death
Cell, 80
M. Boldin, E. Varfolomeev, Z. Pancer, I. Mett, J. Camonis, D. Wallach (1995)
A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain (*)
The Journal of Biological Chemistry, 270
K. Akashi, M. Kondo, U. Freeden-Jeffry, R. Murray, I. Weissman (1997)
Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice
Cell, 89
R. Hotchkiss, Kathy Chang, P. Swanson, K. Tinsley, J. Hui, P. Klender, S. Xanthoudakis, S. Roy, Cameron Black, E. Grimm, Renée Aspiotis, Yongxin Han, D. Nicholson, I. Karl (2000)
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
Nature Immunology, 1
R. Hotchkiss, K. Tinsley, P. Swanson, Katherine Chang, J. Cobb, T. Buchman, S. Korsmeyer, I. Karl (1999)
Prevention of lymphocyte cell death in sepsis improves survival in mice.
Proceedings of the National Academy of Sciences of the United States of America, 96 25
S. Nisitani, Takeshi Tsubata, M. Murakami, Masaya Okamoto, Tasuku Honjo (1993)
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow
The Journal of Experimental Medicine, 178
S. Habu, M. Kimura, M. Katsuki, K. Hioki, T. Nomura (1987)
Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in scid mice
European Journal of Immunology, 17
M. Thome, J. Tschopp (2001)
Regulation of lymphocyte proliferation and death by flip
Nature Reviews Immunology, 1
G. Linette, M. Grusby, S. Hedrick, T. Hansen, L. Glimcher, S. Korsmeyer (1994)
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points.
Immunity, 1 3
M. Capone, R. Hockett, A. Zlotnik (1998)
Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44+CD25+ Pro-T thymocytes
Proceedings of the National Academy of Sciences of the United States of America, 95

Publisher: Annual Reviews
Subject: Review Articles
ISSN: 0732-0582
eISSN: 1545-3278
DOI: 10.1146/annurev.immunol.21.120601.141029
pmid: 12414721
Publisher site: See Article on Publisher Site

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C ONTROL OF A POPTOSIS IN THE I MMUNE S YSTEM : Bcl-2, BH3-Only Proteins and More

C ONTROL OF A POPTOSIS IN THE I MMUNE S YSTEM : Bcl-2, BH3-Only Proteins and More

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C ONTROL OF A POPTOSIS IN THE I MMUNE S YSTEM : Bcl-2, BH3-Only Proteins and More

C ONTROL OF A POPTOSIS IN THE I MMUNE S YSTEM : Bcl-2, BH3-Only Proteins and More

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