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H. Vordermeier, B. Villarreal-Ramos, P. Cockle, M. McAulay, S. Rhodes, T. Thacker, S. Gilbert, H. McShane, A. Hill, Z. Xing, R. Hewinson (2009)
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Protection against bovine tuberculosis induced by oral vaccination of cattle with Mycobacterium bovis BCG is not enhanced by co-administration of mycobacterial protein vaccines.Veterinary immunology and immunopathology, 144 3-4
W. Waters, M. Palmer, B. Nonnecke, T. Thacker, C. Scherer, D. Estes, W. Jacobs, A. Glatman-Freedman, M. Larsen (2007)
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An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovis.Vaccine, 25 24
H. Vordermeier, A. Whelan, P. Cockle, L. Farrant, N. Palmer, R. Hewinson (2001)
Use of Synthetic Peptides Derived from the Antigens ESAT-6 and CFP-10 for Differential Diagnosis of Bovine Tuberculosis in CattleClinical Diagnostic Laboratory Immunology, 8
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K. Ewer, P. Cockle, S. Gordon, H. Mansoor, M. Govaerts, K. Walravens, S. Marché, G. Hewinson, M. Vordermeier (2006)
Antigen Mining with Iterative Genome Screens Identifies Novel Diagnostics for the Mycobacterium tuberculosis ComplexClinical and Vaccine Immunology, 13
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D. Wedlock, M. Denis, H. Vordermeier, R. Hewinson, B. Buddle (2007)
Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFNgamma post-vaccination, but induce similar levels of protection against bovine tuberculosis.Veterinary immunology and immunopathology, 118 1-2
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Screening of Highly Expressed Mycobacterial Genes Identifies Rv3615c as a Useful Differential Diagnostic Antigen for the Mycobacterium tuberculosis ComplexInfection and Immunity, 76
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D. Wedlock, M. Skinner, N. Parlane, H. Vordermeier, R. Hewinson, G. Lisle, B. Buddle (2003)
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Development of an Antibody to Bovine IL-2 Reveals Multifunctional CD4 TEM Cells in Cattle Naturally Infected with Bovine TuberculosisPLoS ONE, 6
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Management of bovine tuberculosis in Michigan wildlife: current status and near term prospects.Veterinary microbiology, 151 1-2
A. Whelan, Jayne Hope, Chris Howard, D. Clifford, R. Hewinson, H. Vordermeier (2003)
Modulation of the Bovine Delayed-Type Hypersensitivity Responses to Defined Mycobacterial Antigens by a Synthetic Bacterial LipopeptideInfection and Immunity, 71
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Use of Antigen-Specific Interleukin-2 To Differentiate between Cattle Vaccinated with Mycobacterium bovis BCG and Cattle Infected with M. bovisClinical and Vaccine Immunology, 21
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Simultaneous Immunization against TuberculosisPLoS ONE, 6
W. Waters, M. Palmer, B. Nonnecke, T. Thacker, C. Scherer, D. Estes, R. Hewinson, H. Vordermeier, S. Barnes, Glenn Federe, J. Walker, R. Glynne, Tsungda Hsu, Brian Weinrick, Karolin Biermann, M. Larsen, W. Jacobs (2009)
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Correlation of ESAT-6-Specific Gamma Interferon Production with Pathology in Cattle following Mycobacterium bovis BCG Vaccination against Experimental Bovine TuberculosisInfection and Immunity, 70
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Analysis of microRNA expression profiling identifies miR-155 and miR-155* as potential diagnostic markers for active tuberculosis: a preliminary study.Human immunology, 73 1
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Enhanced Protection against Bovine Tuberculosis after Coadministration of Mycobacterium bovis BCG with a Mycobacterial Protein Vaccine-Adjuvant Combination but Not after Coadministration of Adjuvant AloneClinical and Vaccine Immunology, 15
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Bovine tuberculosis remains a major economic and animal welfare concern worldwide. Cattle vaccination is being considered as part of control strategies. This approach, used alongside conventional control policies, also requires the development of vaccine-compatible diagnostic assays to distinguish vaccinated from infected animals (DIVA). We discuss progress made on optimizing the only potentially available vaccine, bacille Calmette Guérin (BCG), and on strategies to improve BCG efficacy. We also describe recent advances in DIVA development based on the detection of host cellular immune responses by blood-testing or skin-testing approaches. Finally, to accelerate vaccine development, definition of host biomarkers that provide meaningful stage-gating criteria to select vaccine candidates for further testing is highly desirable. Some progress has also been made in this area of research, and we summarize studies that defined either markers predicting vaccine success or markers that correlate with disease stage or severity.
Annual Review of Animal Biosciences – Annual Reviews
Published: Feb 15, 2016
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