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Biophysical Aspects of Antigen Recognition by T Cells

Biophysical Aspects of Antigen Recognition by T Cells Biological cells can communicate with one another through the release and binding of water soluble substances and also through direct contact between their plasma membranes. A particularly challenging problem in physical chemistry is to determine the molecular events that take place at the interface between the plasma membranes of two cells that specifically "recognize" one another. One approach to this problem is to replace one cell of a pair of interacting cells by a reconstituted membrane that contains just those molecules thought to be responsible for cellular recognition. Interacting pairs of immunological cells provide excellent opportunities for such studies. In fact there are now a number of experiments in which reconstituted membranes arc used to mimic class-II MHC-restricted pep­ tide antigen presentation to T-helper cells (1-10) and to elicit cytotoxic T­ cells by alloantigens (11-17). This review emphasizes the use of planar membranes on solid supports for studies of the nature of the ligand of the T-cell receptor. I Abbreviations: MHC, major histocompatibility complex; RT, the antigen-specific MHC­ restricted T-cell receptor; Te, cytotoxic cell; TH, helper cell; Ag, foreign antigen; M, class-I antigen presenting cell, the ligand of TH cell s ; APT, antigen presenting target, the target http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Biophysical Aspects of Antigen Recognition by T Cells

Watts, T H; McConnell, H M
Annual Review of Immunology , Volume 5 (1) – Apr 1, 1987
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Publisher
Annual Reviews
Copyright
Copyright 1987 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev.iy.05.040187.002333
pmid
3297108
Publisher site
See Article on Publisher Site

Abstract

Biological cells can communicate with one another through the release and binding of water soluble substances and also through direct contact between their plasma membranes. A particularly challenging problem in physical chemistry is to determine the molecular events that take place at the interface between the plasma membranes of two cells that specifically "recognize" one another. One approach to this problem is to replace one cell of a pair of interacting cells by a reconstituted membrane that contains just those molecules thought to be responsible for cellular recognition. Interacting pairs of immunological cells provide excellent opportunities for such studies. In fact there are now a number of experiments in which reconstituted membranes arc used to mimic class-II MHC-restricted pep­ tide antigen presentation to T-helper cells (1-10) and to elicit cytotoxic T­ cells by alloantigens (11-17). This review emphasizes the use of planar membranes on solid supports for studies of the nature of the ligand of the T-cell receptor. I Abbreviations: MHC, major histocompatibility complex; RT, the antigen-specific MHC­ restricted T-cell receptor; Te, cytotoxic cell; TH, helper cell; Ag, foreign antigen; M, class-I antigen presenting cell, the ligand of TH cell s ; APT, antigen presenting target, the target

Journal

Annual Review of Immunology – Annual Reviews

Published: Apr 1, 1987

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