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Biology of CD1- and MR1-Restricted T Cells

Biology of CD1- and MR1-Restricted T Cells Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I–like molecules, CD1 proteins. In this review, we describe the most recent events in the field, with particular emphasis on ( a ) structural and functional aspects of lipid presentation by CD1 molecules, ( b ) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, ( c ) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and ( d ) MR1-restricted and group I (CD1a, CD1b, and CD1c)–restricted T cells. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Immunology Annual Reviews

Biology of CD1- and MR1-Restricted T Cells

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References (367)

Publisher
Annual Reviews
Copyright
Copyright © 2014 by Annual Reviews. All rights reserved
ISSN
0732-0582
eISSN
1545-3278
DOI
10.1146/annurev-immunol-032713-120243
pmid
24499274
Publisher site
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Abstract

Over the past 15 years, investigators have shown that T lymphocytes can recognize not only peptides in the context of MHC class I and class II molecules but also foreign and self-lipids in association with the nonclassical MHC class I–like molecules, CD1 proteins. In this review, we describe the most recent events in the field, with particular emphasis on ( a ) structural and functional aspects of lipid presentation by CD1 molecules, ( b ) the development of CD1d-restricted invariant natural killer T (iNKT) cells and transcription factors required for their differentiation, ( c ) the ability of iNKT cells to modulate innate and adaptive immune responses through their cross talk with lymphoid and myeloid cells, and ( d ) MR1-restricted and group I (CD1a, CD1b, and CD1c)–restricted T cells.

Journal

Annual Review of Immunology – Annual Reviews

Published: Mar 21, 2014

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