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Biological and Enzymatic Events in Chemical Carcinogenesis

Biological and Enzymatic Events in Chemical Carcinogenesis That chemicals and ionizing radiation induce cancer in mammals was first observed in the human. Percival Pott, an eminent English surgeon of the 18th century, published the first clear demonstration of an occupational cancer resulting from chronic exposure to a specific environmental agent, soot. A century later, soon after the discovery of x rays by Roentgen, "radiation cancers" in humans were reported in scientists who utilized radioactive sources. More than a decade later, in 1908, Clunet demon­ strated the experimental production of neoplasia by irradiation (1). Although 200 years have passed since Dr. Pott's report, it has only been within the last three decades that our knowledge of the natural history and biochemistry of chemical carcinogenesis has progressed beyond that of descriptive pathology. The critical experiments allowing for our expanded knowledge of the biology and chemistry of carcinogenesis can be traced to the investigations of Berenblum & Shubik (2, 3) on the natural history of skin carcinogenesis in mice, and to the brilliant experiments of Drs. James and Elizabeth Miller and their associates (4, 5) on the metabolism of chemi­ cal carcinogens. This brief review acquaints the reader with the knowledge that stems from the critical experiments cited http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Biological and Enzymatic Events in Chemical Carcinogenesis

Pitot, H C
Annual Review of Medicine , Volume 30 (1) – Feb 1, 1979
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References (55)

Publisher
Annual Reviews
Copyright
Copyright 1979 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.30.020179.000325
pmid
400494
Publisher site
See Article on Publisher Site

Abstract

That chemicals and ionizing radiation induce cancer in mammals was first observed in the human. Percival Pott, an eminent English surgeon of the 18th century, published the first clear demonstration of an occupational cancer resulting from chronic exposure to a specific environmental agent, soot. A century later, soon after the discovery of x rays by Roentgen, "radiation cancers" in humans were reported in scientists who utilized radioactive sources. More than a decade later, in 1908, Clunet demon­ strated the experimental production of neoplasia by irradiation (1). Although 200 years have passed since Dr. Pott's report, it has only been within the last three decades that our knowledge of the natural history and biochemistry of chemical carcinogenesis has progressed beyond that of descriptive pathology. The critical experiments allowing for our expanded knowledge of the biology and chemistry of carcinogenesis can be traced to the investigations of Berenblum & Shubik (2, 3) on the natural history of skin carcinogenesis in mice, and to the brilliant experiments of Drs. James and Elizabeth Miller and their associates (4, 5) on the metabolism of chemi­ cal carcinogens. This brief review acquaints the reader with the knowledge that stems from the critical experiments cited

Journal

Annual Review of Medicine – Annual Reviews

Published: Feb 1, 1979

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