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By N. KRETCHMER, M.D., PH.D., R. E. GREENBERG, M.D.,3 AND FABIO SERENI, M.D.3 Palo Alto, California, Department of Pediatrics, University of Milan, Milan, Italy Department of Pediatrics, Stanford University School of Medicine, The perinatal period of the mammal is distinguished by remarkable bio chemical lability associated with rapid growth and development. In contrast, when a mammal has attained full growth, its biochemistry and physiology are oriented towards maintenance and repair. During the critical perinatal period, the creature must accommodate to the extreme environmental change of going from a semi aquatic to an aerial existence. It is the purpose of this paper to discuss some aspects of molecular biolo.gy ment during late gestation and early infancy. We do not intend to present a comprehensive review of all the literature, but rather to give selected examples indicating to those who are still doubtful that the perinatal period requires unique physiological thought. ENZYMATIC CHANGES DURING DEVELOPMENT: STRUCTURE AND FUNCTION As early as 1908, Lafayette B. Mendel (1) published a series of now classical papers concerned with the biochemistry of development, and a number of recent reviews (2 to 5) compile the investigations of the past fifty years. Now it is more
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1963
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