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Biochemical Basis of Immaturity

Biochemical Basis of Immaturity By N. KRETCHMER, M.D., PH.D., R. E. GREENBERG, M.D.,3 AND FABIO SERENI, M.D.3 Palo Alto, California, Department of Pediatrics, University of Milan, Milan, Italy Department of Pediatrics, Stanford University School of Medicine, The perinatal period of the mammal is distinguished by remarkable bio­ chemical lability associated with rapid growth and development. In contrast, when a mammal has attained full growth, its biochemistry and physiology are oriented towards maintenance and repair. During the critical perinatal period, the creature must accommodate to the extreme environmental change of going from a semi aquatic to an aerial existence. It is the purpose of this paper to discuss some aspects of molecular biolo.gy ment during late gestation and early infancy. We do not intend to present a comprehensive review of all the literature, but rather to give selected examples indicating to those who are still doubtful that the perinatal period requires unique physiological thought. ENZYMATIC CHANGES DURING DEVELOPMENT: STRUCTURE AND FUNCTION As early as 1908, Lafayette B. Mendel (1) published a series of now classical papers concerned with the biochemistry of development, and a number of recent reviews (2 to 5) compile the investigations of the past fifty years. Now it is more http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Biochemical Basis of Immaturity

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Publisher
Annual Reviews
Copyright
Copyright 1963 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.14.020163.002203
pmid
14035742
Publisher site
See Article on Publisher Site

Abstract

By N. KRETCHMER, M.D., PH.D., R. E. GREENBERG, M.D.,3 AND FABIO SERENI, M.D.3 Palo Alto, California, Department of Pediatrics, University of Milan, Milan, Italy Department of Pediatrics, Stanford University School of Medicine, The perinatal period of the mammal is distinguished by remarkable bio­ chemical lability associated with rapid growth and development. In contrast, when a mammal has attained full growth, its biochemistry and physiology are oriented towards maintenance and repair. During the critical perinatal period, the creature must accommodate to the extreme environmental change of going from a semi aquatic to an aerial existence. It is the purpose of this paper to discuss some aspects of molecular biolo.gy ment during late gestation and early infancy. We do not intend to present a comprehensive review of all the literature, but rather to give selected examples indicating to those who are still doubtful that the perinatal period requires unique physiological thought. ENZYMATIC CHANGES DURING DEVELOPMENT: STRUCTURE AND FUNCTION As early as 1908, Lafayette B. Mendel (1) published a series of now classical papers concerned with the biochemistry of development, and a number of recent reviews (2 to 5) compile the investigations of the past fifty years. Now it is more

Journal

Annual Review of MedicineAnnual Reviews

Published: Feb 1, 1963

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