Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
Platelets contribute significantly to vaso-occlusive thrombosis, one of the major causes of death and disease throughout the world. Consequently, inhibiting platelet function is a potentially important therapeutic goal. Increasing evidence indicates the value of aspirin, a relatively weak anti platelet agent in the prophylaxis and treatment of vascular disease, and of ticlopidine, a somewhat more potent antiplatelet agent that may be somewhat more effective clinically. Recent advances in our understanding of platelet physiology provide crucial information for the rational design of newer agents that can neutralize thrombin and block the platelet recep tor most important in platelet aggregation (GPIIb/IIIa). Several such agents, which are much more potent than aspirin in vitro and in animal models of thrombosis, are now in human clinical trials. INTRODUCTION There is abundant evidence that platelets contribute significantly to the vaso-occlusive thrombotic process that produces ischemic damage in car diovascular, cerebrovascular, and peripheral vascular diseases (1-3). This pathologic role derives from the inability of platelets to differentiate between a damaged normal blood vessel that requires platelet interactions to arrest hemorrhage,and a fractured atherosclerotic plaque, where plate171 0066-4219/92/0401-0171$02.00 COLLER let deposition and aggregation may be lethal. Moreover, from an evol utionary standpoint, individuals with enhanced
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1992
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.