Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Alpha Antitrypsin Deficiency and Pulmonary Emphysema

Alpha Antitrypsin Deficiency and Pulmonary Emphysema Copyright 1971. All rights reserved ALPHAl ANTITRYPSIN DEFICIENCY AND PULMONARY EMPHYSEMA C. A. GUENTER, M.D., M. If. WELCH, M.D., AND]. F. IIAMMARSTEN, M.D. Department of Medicine, University of Oklahoma Medical Center, Oklahoma City, Oklahoma The association of familial alphat antitrypsin deficiency and pulmonary emphysema was first recognized by Laurell & Eriksson ( 1). This observa­ tion was particularly significant because it identified an important relation­ ship between a biochemical abnormality and a common but poorly under­ stood type of lung injury, a relationship that may represent the first docu­ mented disease resulting from a deficiency of proteinase inhibitors. In this review we have summarized the available information regarding the char­ acteristics of serum proteinase inhibitors, the incidence and type of pulmo­ nary disease associated with familial alphal antitrypsin deficiency, and the evidence that pulmonary tissue injury may be related to the deficiency of these inhibitors. PROTEINASE INWBITORS Many naturally occurring proteinase inhibitors in plants and animals have been identified and recently reviewed (2). In some instances such as the soybean, the function of the trypsin inhibitor appears to be incidental; in others, such as the nematode, A sca ris lumbricoides, the inhibitor proper­ ties may be essential for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

Alpha Antitrypsin Deficiency and Pulmonary Emphysema

Loading next page...
 
/lp/annual-reviews/alpha-antitrypsin-deficiency-and-pulmonary-emphysema-7LtK0PibkL

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Annual Reviews
Copyright
Copyright 1971 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.me.22.020171.001435
pmid
4944420
Publisher site
See Article on Publisher Site

Abstract

Copyright 1971. All rights reserved ALPHAl ANTITRYPSIN DEFICIENCY AND PULMONARY EMPHYSEMA C. A. GUENTER, M.D., M. If. WELCH, M.D., AND]. F. IIAMMARSTEN, M.D. Department of Medicine, University of Oklahoma Medical Center, Oklahoma City, Oklahoma The association of familial alphat antitrypsin deficiency and pulmonary emphysema was first recognized by Laurell & Eriksson ( 1). This observa­ tion was particularly significant because it identified an important relation­ ship between a biochemical abnormality and a common but poorly under­ stood type of lung injury, a relationship that may represent the first docu­ mented disease resulting from a deficiency of proteinase inhibitors. In this review we have summarized the available information regarding the char­ acteristics of serum proteinase inhibitors, the incidence and type of pulmo­ nary disease associated with familial alphal antitrypsin deficiency, and the evidence that pulmonary tissue injury may be related to the deficiency of these inhibitors. PROTEINASE INWBITORS Many naturally occurring proteinase inhibitors in plants and animals have been identified and recently reviewed (2). In some instances such as the soybean, the function of the trypsin inhibitor appears to be incidental; in others, such as the nematode, A sca ris lumbricoides, the inhibitor proper­ ties may be essential for

Journal

Annual Review of MedicineAnnual Reviews

Published: Feb 1, 1971

There are no references for this article.