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By BRAM ROSE University Clinic, Royal Victoria Hospital, Montreal, Canada The advent of adrenocorticotropic hormone (ACTH) and cortisone has created broad inroads into all branches of medicine, and in this the field of allergy is no exception. In point of fact, the effectiveness of these two com pounds is probably more promising in the hypersensitive states than in most other conditions for which they have been tried. For this reason, and because a considerable amount of information has been accumulated, this review will be confined to a consideration of the pituitary adrenal mechanism and its relation to hypersensitivity. It would seem worthwhile to recall some of the earlier observations which were begun as long ago as 1922. For example, the marked decrease in re sistance of the guinea pig to a n a phylaxis (1) and the fact that species such as the rat and mouse, normally difficult to sensitize, could be easily rendered hypersensitive by the removal of the adrenal glands (2) were among the first demonstrations that these glands were associated with resistance to anaphylaxis. Similar effects were observed following removal of the pituitary (3). Since there is still no clear cut differentiation between immunity and
Annual Review of Medicine – Annual Reviews
Published: Feb 1, 1951
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