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ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING ▪ Abstract Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Medicine Annual Reviews

ADVANCED PROTEIN GLYCOSYLATION IN DIABETES AND AGING

Annual Review of Medicine , Volume 46 (1) – Feb 1, 1995

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References (74)

Publisher
Annual Reviews
Copyright
Copyright © 1995 by Annual Reviews Inc. All rights reserved
Subject
Review Articles
ISSN
0066-4219
eISSN
1545-326X
DOI
10.1146/annurev.med.46.1.223
pmid
7598459
Publisher site
See Article on Publisher Site

Abstract

▪ Abstract Products of advanced protein glycosylation (advanced glycation end products, or AGEs) accumulate in tissues as a function of time and sugar concentration. AGEs induce permanent abnormalities in extracellular matrix component function, stimulate cytokine and reactive oxygen species production through AGE-specific receptors, and modify intracellular proteins. Pharmacologic inhibition of AGE formation in long-term diabetic animals prevents diabetic retinopathy, nephropathy, neuropathy, and arterial abnormalities in animal models. Clinical trials in humans are currently in progress.

Journal

Annual Review of MedicineAnnual Reviews

Published: Feb 1, 1995

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