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Vectored Expression of the Broadly Neutralizing Antibody FI6 in Mouse Airway Provides Partial Protection against a New Avian Influenza A Virus, H7N9

Vectored Expression of the Broadly Neutralizing Antibody FI6 in Mouse Airway Provides Partial... LETTER As of 4 July 2013, there have been 134 confirmed cases of human infection and 43 fatalities with a new avian influenza A virus (H7N9) ( 1 ). H7N9 is currently contained in Southeastern China, and the majority of human cases of infection have reported direct exposure to poultry ( 2 ). While no sustained human-to-human transmission has been reported, there have been cases of family clusters of infection ( 3 ), suggesting limited person-to-person transmissibility, which, in light of recent findings that H7N9 can be transmitted via aerosol in ferrets ( 4 ), suggests the potential for an H7N9 pandemic. Several broadly neutralizing antibodies against influenza A viruses have been isolated, including FI6 that binds to all group 1 and 2 subtypes of influenza A virus ( 5 ). We previously demonstrated that adeno-associated virus (AAV) vector serotype 9 expressing the FI6 antibody at the nasopharyngeal mucosa of mice and ferrets provided complete protection against clinical isolates of several pandemic strains of H5N1 and H1N1 influenza ( 6 ). We evaluated this strategy in mice for efficacy against a clinical isolate of H7N9 (A/Anhui/01/2013 [A/H1]) ( 7 ). H7N9 A/H1 was isolated in China on 31 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Vectored Expression of the Broadly Neutralizing Antibody FI6 in Mouse Airway Provides Partial Protection against a New Avian Influenza A Virus, H7N9

Vectored Expression of the Broadly Neutralizing Antibody FI6 in Mouse Airway Provides Partial Protection against a New Avian Influenza A Virus, H7N9

Clinical and Vaccine Immunology , Volume 20 (12): 1836 – Dec 1, 2013

Abstract

LETTER As of 4 July 2013, there have been 134 confirmed cases of human infection and 43 fatalities with a new avian influenza A virus (H7N9) ( 1 ). H7N9 is currently contained in Southeastern China, and the majority of human cases of infection have reported direct exposure to poultry ( 2 ). While no sustained human-to-human transmission has been reported, there have been cases of family clusters of infection ( 3 ), suggesting limited person-to-person transmissibility, which, in light of recent findings that H7N9 can be transmitted via aerosol in ferrets ( 4 ), suggests the potential for an H7N9 pandemic. Several broadly neutralizing antibodies against influenza A viruses have been isolated, including FI6 that binds to all group 1 and 2 subtypes of influenza A virus ( 5 ). We previously demonstrated that adeno-associated virus (AAV) vector serotype 9 expressing the FI6 antibody at the nasopharyngeal mucosa of mice and ferrets provided complete protection against clinical isolates of several pandemic strains of H5N1 and H1N1 influenza ( 6 ). We evaluated this strategy in mice for efficacy against a clinical isolate of H7N9 (A/Anhui/01/2013 [A/H1]) ( 7 ). H7N9 A/H1 was isolated in China on 31

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References (13)

Publisher
American Society For Microbiology
Copyright
Copyright © 2013 by the American society for Microbiology.
ISSN
1556-6811
eISSN
1556-679X
DOI
10.1128/CVI.00545-13
pmid
24132603
Publisher site
See Article on Publisher Site

Abstract

LETTER As of 4 July 2013, there have been 134 confirmed cases of human infection and 43 fatalities with a new avian influenza A virus (H7N9) ( 1 ). H7N9 is currently contained in Southeastern China, and the majority of human cases of infection have reported direct exposure to poultry ( 2 ). While no sustained human-to-human transmission has been reported, there have been cases of family clusters of infection ( 3 ), suggesting limited person-to-person transmissibility, which, in light of recent findings that H7N9 can be transmitted via aerosol in ferrets ( 4 ), suggests the potential for an H7N9 pandemic. Several broadly neutralizing antibodies against influenza A viruses have been isolated, including FI6 that binds to all group 1 and 2 subtypes of influenza A virus ( 5 ). We previously demonstrated that adeno-associated virus (AAV) vector serotype 9 expressing the FI6 antibody at the nasopharyngeal mucosa of mice and ferrets provided complete protection against clinical isolates of several pandemic strains of H5N1 and H1N1 influenza ( 6 ). We evaluated this strategy in mice for efficacy against a clinical isolate of H7N9 (A/Anhui/01/2013 [A/H1]) ( 7 ). H7N9 A/H1 was isolated in China on 31

Journal

Clinical and Vaccine ImmunologyAmerican Society For Microbiology

Published: Dec 1, 2013

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