Vaccines: All Things Considered
Abstract
Ken S. Rosenthal1* and Daniel H. Zimmerman2 Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272,1 CEL-SCI Corporation, Vienna, Virginia 221822 This minireview is based on the diverse discussions of vaccine development presented during the GTCBIO Third Annual Conference on Vaccines: All Things Considered (3 to 4 November 2005, Arlington, Va.). As the name implies, the meeting provided an excellent overview of the concepts and concerns for vaccine developers and the vaccine industry and was relevant to individuals in academia, industry, regulatory agencies, implementation, military, government, and physicians. This minireview is divided into the categories that the keynote speaker, Michel Klein (Canadian Network for Vaccines and Immunotherapeutics, Université de Montreal), indicated to be the basis for new vaccine development: (i) biological basis for vaccine development, (ii) new technologies, (iii) new targets, (iv) bringing a vaccine to market, and (v) current issues in vaccine development. Immunization programs have led to the elimination and/or control of several different infectious diseases, including smallpox, polio, measles, mumps, rubella, Haemophilus influenzae type B disease, pertussis, tetanus, and diphtheria. These vaccines were developed using technology from the 19th and 20th centuries, inactivation by heat, chemicals, and irradiation to produce a killed vaccine, vaccination with