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Placental transfer of immunoglobulin G subclasses

Placental transfer of immunoglobulin G subclasses BZ Garty, A Ludomirsky, YL Danon, JB Peter and SD Douglas Kipper Institute of Allergy and Immunology, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva, Israel. The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Placental transfer of immunoglobulin G subclasses

Placental transfer of immunoglobulin G subclasses

Clinical and Vaccine Immunology , Volume 1 (6): 667 – Nov 1, 1994

Abstract

BZ Garty, A Ludomirsky, YL Danon, JB Peter and SD Douglas Kipper Institute of Allergy and Immunology, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva, Israel. The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B.

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Publisher
American Society For Microbiology
Copyright
Copyright © 1994 by the American Society For Microbiology.
ISSN
1556-6811
eISSN
1556-6811
Publisher site
See Article on Publisher Site

Abstract

BZ Garty, A Ludomirsky, YL Danon, JB Peter and SD Douglas Kipper Institute of Allergy and Immunology, Children's Medical Center of Israel, Beilinson Medical Campus, Petah Tiqva, Israel. The concentrations in cord blood of total immunoglobulin G (IgG) and the four subclasses of IgG were measured in 34 fetuses at a mean gestational age of 25 weeks (range, 18 to 35 weeks). The blood samples were obtained by percutaneous umbilical blood sampling, and results were compared with the respective IgG subclass concentrations of the mothers. The efficiency of transplacental transfer of the different IgG subclasses was determined. Transfer of IgG1 and IgG4 was found to be significantly more efficient than that of IgG3 and IgG2. IgG2 was the subclass least efficiently transferred from mother to fetus. These differences may partly explain the susceptibility of newborns to various pathogens, such as streptococcus group B.

Journal

Clinical and Vaccine ImmunologyAmerican Society For Microbiology

Published: Nov 1, 1994

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