Access the full text.
Sign up today, get DeepDyve free for 14 days.
W. Barker, C. Chandler, R. Melander, R. Ernst, C. Melander (2019)
Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria.Bioorganic & medicinal chemistry, 27 9
E. Brown, Gerard Wright (2016)
Antibacterial drug discovery in the resistance eraNature, 529
O. Méndez-Lucio, J. Medina‐Franco (2017)
The many roles of molecular complexity in drug discovery.Drug discovery today, 22 1
(2016)
A scientific roadmap for antibiotic discovery
R. Ihaka, R. Gentleman (1996)
R: a language for data analysis and graphicsJ Comput Graph Stat, 5
M. Kuhn (2008)
Building Predictive Models in R Using the caret PackageJournal of Statistical Software, 28
Y. Takatsuka, Cheng Chen, H. Nikaido (2010)
Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coliProceedings of the National Academy of Sciences, 107
K. Lewis (2020)
The Science of Antibiotic DiscoveryCell, 181
R. Sheridan, Nicolas Zorn, E. Sherer, Louis-Charles Campeau, Charlie Chang, J. Cumming, Matthew Maddess, P. Nantermet, Christopher Sinz, P. O'Shea (2014)
Modeling a Crowdsourced Definition of Molecular ComplexityJournal of chemical information and modeling, 54 6
Jessica Blair, M. Webber, A. Baylay, D. Ogbolu, L. Piddock (2014)
Molecular mechanisms of antibiotic resistanceNature Reviews Microbiology, 13
R. Nakashima, K. Sakurai, S. Yamasaki, Katsuhiko Hayashi, Chikahiro Nagata, K. Hoshino, Y. Onodera, K. Nishino, A. Yamaguchi (2013)
Structural basis for the inhibition of bacterial multidrug exportersNature, 500
G. Krishnamoorthy, I. Leus, Jon Weeks, David Wolloscheck, V. Rybenkov, H. Zgurskaya (2017)
Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative BacteriamBio, 8
Thomas Eicher, H. Cha, M. Seeger, L. Brandstätter, Jasmin El-Delik, Jürgen Bohnert, W. Kern, F. Verrey, M. Grütter, K. Diederichs, K. Pos (2012)
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loopProceedings of the National Academy of Sciences, 109
D. Du, Zhao Wang, N. James, Jarrod Voss, E. Klimont, Thelma Ohene-Agyei, H. Venter, W. Chiu, B. Luisi (2014)
Structure of the AcrAB-TolC multidrug efflux pumpNature, 509
R. Tommasi, Dean Brown, G. Walkup, J. Manchester, Alita Miller (2015)
ESKAPEing the labyrinth of antibacterial discoveryNature Reviews Drug Discovery, 14
(2015)
DataWarrior: an opensource program for chemistry aware data visualization and analysis
S. Lim, H. Nikaido (2010)
Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coliAntimicrobial Agents and Chemotherapy, 54
Dean Brown, Tricia May-Dracka, Moriah Gagnon, R. Tommasi (2014)
Trends and exceptions of physical properties on antibacterial activity for Gram-positive and Gram-negative pathogens.Journal of medicinal chemistry, 57 23
M. Sisay, Lisa Sach-Peltason, J. Bajorath (2009)
Structural Interpretation of Activity Cliffs Revealed by Systematic Analysis of Structure-Activity Relationships in Analog SeriesJournal of chemical information and modeling, 49 10
L. Andrews, Timothy Kane, Paola Dozzo, Cat Haglund, D. Hilderbrandt, M. Linsell, Timothy Machajewski, G. Mcenroe, A. Serio, K. Wlasichuk, D. Neau, S. Pakhomova, G. Waldrop, M. Sharp, J. Pogliano, R. Cirz, F. Cohen (2019)
Optimization and Mechanistic Characterization of Pyridopyrimidine Inhibitors of Bacterial Biotin Carboxylase.Journal of medicinal chemistry
M. Boudreau, Derong Ding, J. Meisel, Jeshina Janardhanan, Edward Spink, Zhihong Peng, Yuanyuan Qian, Takao Yamaguchi, S. Testero, Peter O’Daniel, Erika Leemans, E. Lastochkin, Wei Song, Valerie Schroeder, W. Wolter, M. Suckow, S. Mobashery, Mayland Chang (2019)
Structure-Activity Relationship for the Oxadiazole Class of Antibacterials.ACS medicinal chemistry letters, 11 3
(2017)
Challenges of antibacterial drug discov
L. Verbist (1979)
Comparison of the Activities of the New Ureidopenicillins Piperacillin, Mezlocillin, Azlocillin, and Bay k 4999 Against Gram-Negative OrganismsAntimicrobial Agents and Chemotherapy, 16
(2020)
The science of antibiotic discovery. Cell 181:29–45
M. Richter, Bryon Drown, Andrew Riley, Alfredo Garcia, T. Shirai, Riley Svec, P. Hergenrother (2017)
Predictive compound accumulation rules yield a broad-spectrum antibioticNature, 545
Sarah Cooper, G. Krishnamoorthy, David Wolloscheck, John Walker, V. Rybenkov, Jerry Parks, H. Zgurskaya (2018)
Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa.ACS infectious diseases, 4 8
S. Dutta (1947)
AntibioticsThe Indian Medical Gazette, 82
M. Butler, D. Paterson (2020)
Antibiotics in the clinical pipeline in October 2019The Journal of Antibiotics, 73
Sara Zahed, E. Brown (2018)
Chemical-Chemical Combinations Map Uncharted Interactions in Escherichia coli under Nutrient StressiScience, 2
G. Krishnamoorthy, David Wolloscheck, Jon Weeks, Cameron Croft, V. Rybenkov, H. Zgurskaya (2016)
Breaking the Permeability Barrier of Escherichia coli by Controlled Hyperporination of the Outer MembraneAntimicrobial Agents and Chemotherapy, 60
Xian-Zhi Li, MA 'DZWOKAI, D. Livermore, Hiroshi NIKAIDOl (1994)
Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistanceAntimicrobial Agents and Chemotherapy, 38
A. Vargiu, P. Ruggerone, T. Opperman, S. Nguyen, H. Nikaido (2014)
Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other InhibitorsAntimicrobial Agents and Chemotherapy, 58
S. Murakami, R. Nakashima, E. Yamashita, Takashi Matsumoto, A. Yamaguchi (2006)
Crystal structures of a multidrug transporter reveal a functionally rotating mechanismNature, 443
R. Nakashima, K. Sakurai, S. Yamasaki, K. Nishino, A. Yamaguchi (2011)
Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocketNature, 480
(2017)
Challenges in the discovery of Gram-negative antibacterials: the entry and efflux problem
F. Reck, J. Jansen, H. Moser (2019)
Challenges of antibacterial drug discoveryArkivoc
(2019)
antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline. World Health Organization
C. Mangat, A. Bharat, Sebastian Gehrke, E. Brown (2014)
Rank Ordering Plate Data Facilitates Data Visualization and Normalization in High-Throughput ScreeningJournal of Biomolecular Screening, 19
(2003)
Antibiotics. American Society for Microbiology, Washington, DC
C. Lipinski, F. Lombardo, B. Dominy, P. Feeney (2001)
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.Advanced drug delivery reviews, 46 1-3
Ross Ihaka (1996)
Gentleman R: R: A language for data analysis and graphics
R. O’Shea, H. Moser (2008)
Physicochemical properties of antibacterial compounds: implications for drug discovery.Journal of medicinal chemistry, 51 10
(2013)
Structural basis for the inhibition of bacterial multidrug exporters. Nature 500:102–106
A. Vargiu, H. Nikaido (2012)
Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulationsProceedings of the National Academy of Sciences, 109
Muriel Masi, M. Réfrégiers, K. Pos, J. Pagés (2017)
Erratum: Unusual marine unicellular symbiosis with the nitrogen-fixing cyanobacterium UCYN-ANature Microbiology, 2
Carolyn Shore, Allan Coukell (2016)
Roadmap for antibiotic discoveryNature Microbiology, 1
R. Novick (1962)
Staphylococcal penicillinase and the new penicillins.The Biochemical journal, 83
Jürgen Bohnert, S. Schuster, M. Seeger, Eva Fähnrich, K. Pos, W. Kern (2008)
Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrBJournal of Bacteriology, 190
T. Baba, T. Ara, Miki Hasegawa, Yuki Takai, Yoshiko Okumura, Miki Baba, K. Datsenko, M. Tomita, B. Wanner, H. Mori (2006)
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionMolecular Systems Biology, 2
J. Knowles (1985)
Penicillin resistance: the chemistry of .beta.-lactamase inhibitionAccounts of Chemical Research, 18
P. Moja (2017)
Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug resistant bacterial infections, including tuberculosis
D. Payne, M. Gwynn, D. Holmes, D. Pompliano (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discoveryNature Reviews Drug Discovery, 6
S. Solomon, Kristen Oliver (2014)
Antibiotic resistance threats in the United States: stepping back from the brink.American family physician, 89 12
(2010)
Three decades of b-lactamase inhibitors
Xian-Zhi Li, P. Plésiat, H. Nikaido (2015)
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative BacteriaClinical Microbiology Reviews, 28
Antimicrobial Agents and Chemotherapy – American Society For Microbiology
Published: Mar 18, 2021
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.