Mapping of the H7-serospecific domain of Escherichia coli flagellin
Clinical and Vaccine Immunology
, Volume 3 (5): 523 – Sep 1, 1996
Abstract
J Kwang, R Wilson, S Yang and Y He U.S. Meat Animal Research Center, U.S. Department of Agriculture, Clay Center, Nebraska 68933, USA. The amino acid sequences responsible for H7 and H23 flagellum serology have been identified by using a genetic approach. The H7-specific domain was located between amino acids 352 and 374 of the H7 flagellin. The sequencing data also demonstrated that the difference between the H7 and H23 flagellins in this region results from a single substitution at amino acid 366 (Ser-->Thr). The common epitopes for H7 and H23 were located between amino acids 284 and 366.
