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Interaction between Endogenous Bacterial Flora and Latent HIV Infection

Interaction between Endogenous Bacterial Flora and Latent HIV Infection Interaction between Endogenous Bacterial Flora and Latent HIV Infection Ann Florence B. Victoriano a , Kenichi Imai a , b and Takashi Okamoto a Department of Molecular and Cellular Biology, Nagoya City University Graduate School for Medical Sciences, Nagoya, Japan a Department of Microbiology, Division of Immunology, and Pathobiology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan b ABSTRACT Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment HIV replication, in particular, viral replication from latently infected cells, which is attributable to the effect of butyric acid produced by certain anaerobic bacteria by modifying the state of chromatin. Here, we review recent evidence supporting the contributory role of such endogenous microbes in disrupting HIV latency and its potential link to the clinical progression of AIDS. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Interaction between Endogenous Bacterial Flora and Latent HIV Infection

Interaction between Endogenous Bacterial Flora and Latent HIV Infection

Clinical and Vaccine Immunology , Volume 20 (6): 773 – Jun 1, 2013

Abstract

Interaction between Endogenous Bacterial Flora and Latent HIV Infection Ann Florence B. Victoriano a , Kenichi Imai a , b and Takashi Okamoto a Department of Molecular and Cellular Biology, Nagoya City University Graduate School for Medical Sciences, Nagoya, Japan a Department of Microbiology, Division of Immunology, and Pathobiology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan b ABSTRACT Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment HIV replication, in particular, viral replication from latently infected cells, which is attributable to the effect of butyric acid produced by certain anaerobic bacteria by modifying the state of chromatin. Here, we review recent evidence supporting the contributory role of such endogenous microbes in disrupting HIV latency and its potential link to the clinical progression of AIDS.

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References (98)

Publisher
American Society For Microbiology
Copyright
Copyright © 2013 by the American society for Microbiology.
ISSN
1556-6811
eISSN
1556-679X
DOI
10.1128/CVI.00766-12
pmid
23616411
Publisher site
See Article on Publisher Site

Abstract

Interaction between Endogenous Bacterial Flora and Latent HIV Infection Ann Florence B. Victoriano a , Kenichi Imai a , b and Takashi Okamoto a Department of Molecular and Cellular Biology, Nagoya City University Graduate School for Medical Sciences, Nagoya, Japan a Department of Microbiology, Division of Immunology, and Pathobiology, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan b ABSTRACT Human commensal bacteria do not normally cause any diseases. However, in certain pathological conditions, they exhibit a number of curious behaviors. In HIV infection, these bacteria exhibit bidirectional relationships: whereas they cause opportunistic infections based on immunological deterioration, they also augment HIV replication, in particular, viral replication from latently infected cells, which is attributable to the effect of butyric acid produced by certain anaerobic bacteria by modifying the state of chromatin. Here, we review recent evidence supporting the contributory role of such endogenous microbes in disrupting HIV latency and its potential link to the clinical progression of AIDS.

Journal

Clinical and Vaccine ImmunologyAmerican Society For Microbiology

Published: Jun 1, 2013

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