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Influence of Interleukin 1{alpha} (IL-1{alpha}), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis

Influence of Interleukin 1{alpha} (IL-1{alpha}), IL-4, and IL-6 Polymorphisms on Genetic... The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1 (IL-1 ) –889-C/T, IL-4 –1098-G/T and –590-C/T, and IL-6 –174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Influence of Interleukin 1{alpha} (IL-1{alpha}), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis

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Influence of Interleukin 1{alpha} (IL-1{alpha}), IL-4, and IL-6 Polymorphisms on Genetic Susceptibility to Chronic Osteomyelitis

Tsezou, Aspasia; Poultsides, Lazaros; Kostopoulou, Fotini; Zintzaras, Elias; Satra, Maria; Kitsiou-Tzeli, Sofia; Malizos, Konstantinos N.
Clinical and Vaccine Immunology , Volume 15 (12): 1888 – Dec 1, 2008

Abstract

The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1 (IL-1 ) –889-C/T, IL-4 –1098-G/T and –590-C/T, and IL-6 –174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.

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References (18)

Publisher
American Society For Microbiology
Copyright
Copyright © 2008 by the American Society For Microbiology.
ISSN
1556-6811
eISSN
1556-6811
DOI
10.1128/CVI.00209-08
Publisher site
See Article on Publisher Site

Abstract

The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1 (IL-1 ) –889-C/T, IL-4 –1098-G/T and –590-C/T, and IL-6 –174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis.

Journal

Clinical and Vaccine Immunology – American Society For Microbiology

Published: Dec 1, 2008

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