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Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of... Downloaded from http://jvi.asm.org/ on May 14, 2021 by guest VACCINES AND ANTIVIRAL AGENTS Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells a b,c d b,c e Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA High Throughput Analysis Laboratory, Northwestern University, Evanston, Illinois, USA Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Visiting Scholar, Northwestern University, Evanston, Illinois, USA Chicago Biomedical Consortium, Northwestern University, Evanston, Illinois, USA ABSTRACT In many enveloped virus families, including human immunodeficiency virus (HIV) and herpes simplex virus (HSV), a crucial, yet unexploited, step in the viral life cycle is the release of particles from the infected cell membranes. This release process is mediated by host ESCRT complex proteins, which are recruited by viral structural proteins and provide the mechanical means for membrane scission and subsequent viral budding. The prazole drug tenatoprazole was previously shown to bind to the ESCRT complex member Tsg101 and to quantitatively block the release of infectious HIV-1 from cells in culture. In this report, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Virology American Society For Microbiology

Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells

Journal of Virology , Volume 95 (11) – May 10, 2021

Abstract

Downloaded from http://jvi.asm.org/ on May 14, 2021 by guest VACCINES AND ANTIVIRAL AGENTS Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells a b,c d b,c e Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA High Throughput Analysis Laboratory, Northwestern University, Evanston, Illinois, USA Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Visiting Scholar, Northwestern University, Evanston, Illinois, USA Chicago Biomedical Consortium, Northwestern University, Evanston, Illinois, USA ABSTRACT In many enveloped virus families, including human immunodeficiency virus (HIV) and herpes simplex virus (HSV), a crucial, yet unexploited, step in the viral life cycle is the release of particles from the infected cell membranes. This release process is mediated by host ESCRT complex proteins, which are recruited by viral structural proteins and provide the mechanical means for membrane scission and subsequent viral budding. The prazole drug tenatoprazole was previously shown to bind to the ESCRT complex member Tsg101 and to quantitatively block the release of infectious HIV-1 from cells in culture. In this report,

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References (124)

Publisher
American Society For Microbiology
Copyright
Copyright © 2021 Leis et al.
ISSN
0022-538X
eISSN
1098-5514
DOI
10.1128/jvi.00190-21
Publisher site
See Article on Publisher Site

Abstract

Downloaded from http://jvi.asm.org/ on May 14, 2021 by guest VACCINES AND ANTIVIRAL AGENTS Ilaprazole and Other Novel Prazole-Based Compounds That Bind Tsg101 Inhibit Viral Budding of Herpes Simplex Virus 1 and 2 and Human Immunodeficiency Virus from Cells a b,c d b,c e Jonathan Leis, Chi-Hao Luan, James E. Audia, Sara F. Dunne, Carissa M. Heath Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA High Throughput Analysis Laboratory, Northwestern University, Evanston, Illinois, USA Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA Visiting Scholar, Northwestern University, Evanston, Illinois, USA Chicago Biomedical Consortium, Northwestern University, Evanston, Illinois, USA ABSTRACT In many enveloped virus families, including human immunodeficiency virus (HIV) and herpes simplex virus (HSV), a crucial, yet unexploited, step in the viral life cycle is the release of particles from the infected cell membranes. This release process is mediated by host ESCRT complex proteins, which are recruited by viral structural proteins and provide the mechanical means for membrane scission and subsequent viral budding. The prazole drug tenatoprazole was previously shown to bind to the ESCRT complex member Tsg101 and to quantitatively block the release of infectious HIV-1 from cells in culture. In this report,

Journal

Journal of VirologyAmerican Society For Microbiology

Published: May 10, 2021

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