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IL23R(Arg381Gln) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity

IL23R(Arg381Gln) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity IL23R ( Arg381Gln ) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity Walid Ben-Selma and Jalel Boukadida Laboratory of Microbiology and Immunology, Farhat Hached University Hospital, Sousse, Tunisia ABSTRACT The purpose of our study was to investigate the association between a functional single nucleotide polymorphism (SNP) in the interleukin-23 receptor gene ( IL23R ; rs11209026, 1142 G wild type → A reduced function , Arg381Gln) and disease severity outcome in pulmonary tuberculosis (TB) in the Tunisian population. SNP was investigated in a population of 168 patients with active pulmonary TB (cases were stratified into patients with minimal/moderate lung involvement, i.e., patients with minimal/moderate disease (Pmd), and patients with extensive lung involvement, i.e., patients with active disease (Pad)) and 150 healthy subjects. Genotype analyses were carried out using the PCR-restriction fragment length polymorphism method. We have found that the IL23R reduced-function allele 1142A and genotypes AA and AG were overrepresented, especially in the Pad subgroup compared with the control group (51% versus 18% ( P = 10 −8 ), 33% versus 5% ( P = 10 −8 ), and 36% versus 26% ( P = 5 × 10 −3 ), respectively). Additionally, comparison of the Pad and the Pmd groups showed that the A allele and AA genotype seemed to be associated with 2.79-fold ( P = 4 × 10 −5 ) and 7.74-fold ( P = 10 −5 ) increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G → A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in Tunisian patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

IL23R(Arg381Gln) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity

IL23R(Arg381Gln) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity

Clinical and Vaccine Immunology , Volume 19 (8): 1188 – Aug 1, 2012

Abstract

IL23R ( Arg381Gln ) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity Walid Ben-Selma and Jalel Boukadida Laboratory of Microbiology and Immunology, Farhat Hached University Hospital, Sousse, Tunisia ABSTRACT The purpose of our study was to investigate the association between a functional single nucleotide polymorphism (SNP) in the interleukin-23 receptor gene ( IL23R ; rs11209026, 1142 G wild type → A reduced function , Arg381Gln) and disease severity outcome in pulmonary tuberculosis (TB) in the Tunisian population. SNP was investigated in a population of 168 patients with active pulmonary TB (cases were stratified into patients with minimal/moderate lung involvement, i.e., patients with minimal/moderate disease (Pmd), and patients with extensive lung involvement, i.e., patients with active disease (Pad)) and 150 healthy subjects. Genotype analyses were carried out using the PCR-restriction fragment length polymorphism method. We have found that the IL23R reduced-function allele 1142A and genotypes AA and AG were overrepresented, especially in the Pad subgroup compared with the control group (51% versus 18% ( P = 10 −8 ), 33% versus 5% ( P = 10 −8 ), and 36% versus 26% ( P = 5 × 10 −3 ), respectively). Additionally, comparison of the Pad and the Pmd groups showed that the A allele and AA genotype seemed to be associated with 2.79-fold ( P = 4 × 10 −5 ) and 7.74-fold ( P = 10 −5 ) increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G → A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in Tunisian patients.

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References (52)

Publisher
American Society For Microbiology
Copyright
Copyright © 2012 by the American society for Microbiology.
ISSN
1556-6811
eISSN
1556-679X
DOI
10.1128/CVI.00135-12
pmid
22695161
Publisher site
See Article on Publisher Site

Abstract

IL23R ( Arg381Gln ) Functional Polymorphism Is Associated with Active Pulmonary Tuberculosis Severity Walid Ben-Selma and Jalel Boukadida Laboratory of Microbiology and Immunology, Farhat Hached University Hospital, Sousse, Tunisia ABSTRACT The purpose of our study was to investigate the association between a functional single nucleotide polymorphism (SNP) in the interleukin-23 receptor gene ( IL23R ; rs11209026, 1142 G wild type → A reduced function , Arg381Gln) and disease severity outcome in pulmonary tuberculosis (TB) in the Tunisian population. SNP was investigated in a population of 168 patients with active pulmonary TB (cases were stratified into patients with minimal/moderate lung involvement, i.e., patients with minimal/moderate disease (Pmd), and patients with extensive lung involvement, i.e., patients with active disease (Pad)) and 150 healthy subjects. Genotype analyses were carried out using the PCR-restriction fragment length polymorphism method. We have found that the IL23R reduced-function allele 1142A and genotypes AA and AG were overrepresented, especially in the Pad subgroup compared with the control group (51% versus 18% ( P = 10 −8 ), 33% versus 5% ( P = 10 −8 ), and 36% versus 26% ( P = 5 × 10 −3 ), respectively). Additionally, comparison of the Pad and the Pmd groups showed that the A allele and AA genotype seemed to be associated with 2.79-fold ( P = 4 × 10 −5 ) and 7.74-fold ( P = 10 −5 ) increased risks of TB with minimal/moderate lung involvement, respectively. Our results demonstrate that the reduced-function polymorphism 1142G → A encoded by IL23R influences the outcome of disease severity of active pulmonary TB in Tunisian patients.

Journal

Clinical and Vaccine ImmunologyAmerican Society For Microbiology

Published: Aug 1, 2012

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