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FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

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FoxA2 Involvement in Suppression of Protein C, an Outcome Predictor in Experimental Sepsis

Berg, David T.; Gerlitz, Bruce; Sharma, Ganesh R.; Richardson, Mark A.; Stephens, Eddie J.; Grubbs, Renee L.; Holmes, Kimberly C.; Fynboe, Kelly; Montani, Dominick; Cramer, Martin S.; Engle, Steven D.; Jakubowski, Joseph A.; Heuer, Josef G.; Grinnell, Brian W.
Clinical and Vaccine Immunology , Volume 13 (3): 426 – Mar 1, 2006

Abstract

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.

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Publisher
American Society For Microbiology
Copyright
Copyright © 2006 by the American Society For Microbiology.
ISSN
1556-6811
eISSN
1556-6811
DOI
10.1128/CVI.13.3.426-432.2006
Publisher site
See Article on Publisher Site

Abstract

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.

Journal

Clinical and Vaccine Immunology – American Society For Microbiology

Published: Mar 1, 2006

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