-
(SchwartzO, AlbertML
2010
Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol
8:491–500. doi:10.1038/nrmicro2368.20551973)
SchwartzO, AlbertML
2010
Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol
8:491–500. doi:10.1038/nrmicro2368.20551973
SchwartzO, AlbertML
2010
Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol
8:491–500. doi:10.1038/nrmicro2368.20551973, SchwartzO, AlbertML
2010
Biology and pathogenesis of chikungunya virus. Nat Rev Microbiol
8:491–500. doi:10.1038/nrmicro2368.20551973
-
(SulowayC, PulokasJ, FellmannD, ChengA, GuerraF, QuispeJ, StaggS, PotterCS, CarragherB
2005
Automated molecular microscopy: the new Leginon system. J Struct Biol
151:41–60. doi:10.1016/j.jsb.2005.03.010.15890530)
SulowayC, PulokasJ, FellmannD, ChengA, GuerraF, QuispeJ, StaggS, PotterCS, CarragherB
2005
Automated molecular microscopy: the new Leginon system. J Struct Biol
151:41–60. doi:10.1016/j.jsb.2005.03.010.15890530
SulowayC, PulokasJ, FellmannD, ChengA, GuerraF, QuispeJ, StaggS, PotterCS, CarragherB
2005
Automated molecular microscopy: the new Leginon system. J Struct Biol
151:41–60. doi:10.1016/j.jsb.2005.03.010.15890530, SulowayC, PulokasJ, FellmannD, ChengA, GuerraF, QuispeJ, StaggS, PotterCS, CarragherB
2005
Automated molecular microscopy: the new Leginon system. J Struct Biol
151:41–60. doi:10.1016/j.jsb.2005.03.010.15890530
-
L.
Foquet,
C.
Hermsen,
G.
Gemert,
E.
Braeckel,
K.
Weening,
R.
Sauerwein,
P.
Meuleman,
G.
Leroux-Roels
(2014)
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection.
The Journal of clinical investigation, 124 1
-
(TissotAC, RenhofaR, SchmitzN, CielensI, MeijerinkE, OseV, JenningsGT, SaudanP, PumpensP, BachmannMF
2010
Versatile virus-like particle carrier for epitope based vaccines. PLoS One
5:e9809. doi:10.1371/journal.pone.0009809.20352110)
TissotAC, RenhofaR, SchmitzN, CielensI, MeijerinkE, OseV, JenningsGT, SaudanP, PumpensP, BachmannMF
2010
Versatile virus-like particle carrier for epitope based vaccines. PLoS One
5:e9809. doi:10.1371/journal.pone.0009809.20352110
TissotAC, RenhofaR, SchmitzN, CielensI, MeijerinkE, OseV, JenningsGT, SaudanP, PumpensP, BachmannMF
2010
Versatile virus-like particle carrier for epitope based vaccines. PLoS One
5:e9809. doi:10.1371/journal.pone.0009809.20352110, TissotAC, RenhofaR, SchmitzN, CielensI, MeijerinkE, OseV, JenningsGT, SaudanP, PumpensP, BachmannMF
2010
Versatile virus-like particle carrier for epitope based vaccines. PLoS One
5:e9809. doi:10.1371/journal.pone.0009809.20352110
-
F.
Buonaguro,
L.
Buonaguro
(2014)
Virus-like particles in vaccine development
-
F.
Khan,
Michael
Porter,
R.
Schwenk,
M.
Debot,
P.
Saudan,
S.
Dutta
(2015)
Head-to-Head Comparison of Soluble vs. Qβ VLP Circumsporozoite Protein Vaccines Reveals Selective Enhancement of NANP Repeat Responses
PLoS ONE, 10
-
A.
Tissot,
Regīna
Renhofa,
N.
Schmitz,
I.
Cielēns,
E.
Meijerink,
V.
Ose,
G.
Jennings,
P.
Saudan,
P.
Pumpens,
M.
Bachmann
(2010)
Versatile Virus-Like Particle Carrier for Epitope Based Vaccines
PLoS ONE, 5
-
(PlummerEM, ManchesterM
2011
Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip Rev Nanomed Nanobiotechnol
3:174–196. doi:10.1002/wnan.119.20872839)
PlummerEM, ManchesterM
2011
Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip Rev Nanomed Nanobiotechnol
3:174–196. doi:10.1002/wnan.119.20872839
PlummerEM, ManchesterM
2011
Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip Rev Nanomed Nanobiotechnol
3:174–196. doi:10.1002/wnan.119.20872839, PlummerEM, ManchesterM
2011
Viral nanoparticles and virus-like particles: platforms for contemporary vaccine design. Wiley Interdiscip Rev Nanomed Nanobiotechnol
3:174–196. doi:10.1002/wnan.119.20872839
-
O.
Bruna-Romero,
J.
Hafalla,
G.
González-Aseguinolaza,
G.
Sano,
M.
Tsuji,
F.
Zavala
(2001)
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR.
International journal for parasitology, 31 13
-
(2013)
RTS , S / AS 02 A
-
(BirkettA, LyonsK, SchmidtA, BoydD, OliveiraGA, SiddiqueA, NussenzweigR, Calvo-CalleJM, NardinE
2002
A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect Immun
70:6860–6870. doi:10.1128/IAI.70.12.6860-6870.2002.12438363)
BirkettA, LyonsK, SchmidtA, BoydD, OliveiraGA, SiddiqueA, NussenzweigR, Calvo-CalleJM, NardinE
2002
A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect Immun
70:6860–6870. doi:10.1128/IAI.70.12.6860-6870.2002.12438363
BirkettA, LyonsK, SchmidtA, BoydD, OliveiraGA, SiddiqueA, NussenzweigR, Calvo-CalleJM, NardinE
2002
A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect Immun
70:6860–6870. doi:10.1128/IAI.70.12.6860-6870.2002.12438363, BirkettA, LyonsK, SchmidtA, BoydD, OliveiraGA, SiddiqueA, NussenzweigR, Calvo-CalleJM, NardinE
2002
A modified hepatitis B virus core particle containing multiple epitopes of the Plasmodium falciparum circumsporozoite protein provides a highly immunogenic malaria vaccine in preclinical analyses in rodent and primate hosts. Infect Immun
70:6860–6870. doi:10.1128/IAI.70.12.6860-6870.2002.12438363
-
(RoldaoA, MelladoMC, CastilhoLR, CarrondoMJ, AlvesPM
2010
Virus-like particles in vaccine development. Expert Rev Vaccines
9:1149–1176. doi:10.1586/erv.10.115.20923267)
RoldaoA, MelladoMC, CastilhoLR, CarrondoMJ, AlvesPM
2010
Virus-like particles in vaccine development. Expert Rev Vaccines
9:1149–1176. doi:10.1586/erv.10.115.20923267
RoldaoA, MelladoMC, CastilhoLR, CarrondoMJ, AlvesPM
2010
Virus-like particles in vaccine development. Expert Rev Vaccines
9:1149–1176. doi:10.1586/erv.10.115.20923267, RoldaoA, MelladoMC, CastilhoLR, CarrondoMJ, AlvesPM
2010
Virus-like particles in vaccine development. Expert Rev Vaccines
9:1149–1176. doi:10.1586/erv.10.115.20923267
-
(KanekiyoM, WeiCJ, YassineHM, McTamneyPM, BoyingtonJC, WhittleJR, RaoSS, KongWP, WangL, NabelGJ
2013
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature
499:102–106. doi:10.1038/nature12202.23698367)
KanekiyoM, WeiCJ, YassineHM, McTamneyPM, BoyingtonJC, WhittleJR, RaoSS, KongWP, WangL, NabelGJ
2013
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature
499:102–106. doi:10.1038/nature12202.23698367
KanekiyoM, WeiCJ, YassineHM, McTamneyPM, BoyingtonJC, WhittleJR, RaoSS, KongWP, WangL, NabelGJ
2013
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature
499:102–106. doi:10.1038/nature12202.23698367, KanekiyoM, WeiCJ, YassineHM, McTamneyPM, BoyingtonJC, WhittleJR, RaoSS, KongWP, WangL, NabelGJ
2013
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature
499:102–106. doi:10.1038/nature12202.23698367
-
L.
Casten,
S.
Pierce
(1988)
Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures.
Journal of immunology, 140 2
-
V.
Stewart,
S.
McGrath,
D.
Walsh,
S.
Davis,
A.
Hess,
L.
Ware,
K.
Kester,
J.
Cummings,
J.
Burge,
G.
Voss,
M.
Delchambre,
N.
Garçon,
D.
Tang,
Joe
Cohen,
D.
Heppner
(2006)
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A.
Vaccine, 24 42-43
-
Guang
Tang,
L.
Peng,
P.
Baldwin,
D.
Mann,
Wen
Jiang,
I.
Rees,
S.
Ludtke
(2007)
EMAN2: an extensible image processing suite for electron microscopy.
Journal of structural biology, 157 1
-
(2010)
A virus-like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection
-
(LumFM, NgLF
2015
Cellular and molecular mechanisms of chikungunya pathogenesis. Antiviral Res
120:165–174. doi:10.1016/j.antiviral.2015.06.009.26092642)
LumFM, NgLF
2015
Cellular and molecular mechanisms of chikungunya pathogenesis. Antiviral Res
120:165–174. doi:10.1016/j.antiviral.2015.06.009.26092642
LumFM, NgLF
2015
Cellular and molecular mechanisms of chikungunya pathogenesis. Antiviral Res
120:165–174. doi:10.1016/j.antiviral.2015.06.009.26092642, LumFM, NgLF
2015
Cellular and molecular mechanisms of chikungunya pathogenesis. Antiviral Res
120:165–174. doi:10.1016/j.antiviral.2015.06.009.26092642
-
Lee-Jah
Chang,
Kimberly
Dowd,
Floreliz
Mendoza,
J.
Saunders,
S.
Sitar,
Sarah
Plummer,
G.
Yamshchikov,
U.
Sarwar,
Zonghui
Hu,
M.
Enama,
R.
Bailer,
R.
Koup,
Richard
Schwartz,
W.
Akahata,
G.
Nabel,
J.
Mascola,
T.
Pierson,
B.
Graham,
J.
Ledgerwood
(2014)
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial
The Lancet, 384
-
(KushnirN, StreatfieldSJ, YusibovV
2012
Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development. Vaccine
31:58–83. doi:10.1016/j.vaccine.2012.10.083.23142589)
KushnirN, StreatfieldSJ, YusibovV
2012
Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development. Vaccine
31:58–83. doi:10.1016/j.vaccine.2012.10.083.23142589
KushnirN, StreatfieldSJ, YusibovV
2012
Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development. Vaccine
31:58–83. doi:10.1016/j.vaccine.2012.10.083.23142589, KushnirN, StreatfieldSJ, YusibovV
2012
Virus-like particles as a highly efficient vaccine platform: diversity of targets and production systems and advances in clinical development. Vaccine
31:58–83. doi:10.1016/j.vaccine.2012.10.083.23142589
-
(RegulesJA, CummingsJF, OckenhouseCF
2011
The RTS,S vaccine candidate for malaria. Expert Rev Vaccines
10:589–599. doi:10.1586/erv.11.57.21604980)
RegulesJA, CummingsJF, OckenhouseCF
2011
The RTS,S vaccine candidate for malaria. Expert Rev Vaccines
10:589–599. doi:10.1586/erv.11.57.21604980
RegulesJA, CummingsJF, OckenhouseCF
2011
The RTS,S vaccine candidate for malaria. Expert Rev Vaccines
10:589–599. doi:10.1586/erv.11.57.21604980, RegulesJA, CummingsJF, OckenhouseCF
2011
The RTS,S vaccine candidate for malaria. Expert Rev Vaccines
10:589–599. doi:10.1586/erv.11.57.21604980
-
G.
Galfrè,
C.
Milstein
(1981)
[1] Preparation of monoclonal antibodies: Strategies and procedures
Methods in Enzymology, 73
-
Xueming
Li,
P.
Mooney,
S.
Zheng,
C.
Booth,
M.
Braunfeld,
S.
Gubbens,
D.
Agard,
Yifan
Cheng
(2013)
Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM
Nature methods, 10
-
(VossJE, VaneyMC, DuquerroyS, VonrheinC, Girard-BlancC, CrubletE, ThompsonA, BricogneG, ReyFA
2010
Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature
468:709–712. doi:10.1038/nature09555.21124458)
VossJE, VaneyMC, DuquerroyS, VonrheinC, Girard-BlancC, CrubletE, ThompsonA, BricogneG, ReyFA
2010
Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature
468:709–712. doi:10.1038/nature09555.21124458
VossJE, VaneyMC, DuquerroyS, VonrheinC, Girard-BlancC, CrubletE, ThompsonA, BricogneG, ReyFA
2010
Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature
468:709–712. doi:10.1038/nature09555.21124458, VossJE, VaneyMC, DuquerroyS, VonrheinC, Girard-BlancC, CrubletE, ThompsonA, BricogneG, ReyFA
2010
Glycoprotein organization of chikungunya virus particles revealed by X-ray crystallography. Nature
468:709–712. doi:10.1038/nature09555.21124458
-
(NoadR, RoyP
2003
Virus-like particles as immunogens. Trends Microbiol
11:438–444. doi:10.1016/S0966-842X(03)00208-7.13678860)
NoadR, RoyP
2003
Virus-like particles as immunogens. Trends Microbiol
11:438–444. doi:10.1016/S0966-842X(03)00208-7.13678860
NoadR, RoyP
2003
Virus-like particles as immunogens. Trends Microbiol
11:438–444. doi:10.1016/S0966-842X(03)00208-7.13678860, NoadR, RoyP
2003
Virus-like particles as immunogens. Trends Microbiol
11:438–444. doi:10.1016/S0966-842X(03)00208-7.13678860
-
R.
Henderson,
A.
Sali,
M.
Baker,
B.
Carragher,
B.
Devkota,
K.
Downing,
E.
Egelman,
Zukang
Feng,
J.
Frank,
N.
Grigorieff,
Wen
Jiang,
S.
Ludtke,
O.
Medalia,
P.
Penczek,
P.
Rosenthal,
M.
Rossmann,
M.
Schmid,
G.
Schröder,
A.
Steven,
D.
Stokes,
J.
Westbrook,
W.
Wriggers,
Huanwang
Yang,
Jasmine
Young,
H.
Berman,
W.
Chiu,
G.
Kleywegt,
C.
Lawson
(2012)
Outcome of the First Electron Microscopy Validation Task Force Meeting
Structure(London, England:1993), 20-330
-
(MindellJA, GrigorieffN
2003
Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol
142:334–347. doi:10.1016/S1047-8477(03)00069-8.12781660)
MindellJA, GrigorieffN
2003
Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol
142:334–347. doi:10.1016/S1047-8477(03)00069-8.12781660
MindellJA, GrigorieffN
2003
Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol
142:334–347. doi:10.1016/S1047-8477(03)00069-8.12781660, MindellJA, GrigorieffN
2003
Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol
142:334–347. doi:10.1016/S1047-8477(03)00069-8.12781660
-
(GuoF, JiangW
2014
Single particle cryo-electron microscopy and 3-D reconstruction of viruses. Methods Mol Biol
1117:401–443. doi:10.1007/978-1-62703-776-1_19.24357374)
GuoF, JiangW
2014
Single particle cryo-electron microscopy and 3-D reconstruction of viruses. Methods Mol Biol
1117:401–443. doi:10.1007/978-1-62703-776-1_19.24357374
GuoF, JiangW
2014
Single particle cryo-electron microscopy and 3-D reconstruction of viruses. Methods Mol Biol
1117:401–443. doi:10.1007/978-1-62703-776-1_19.24357374, GuoF, JiangW
2014
Single particle cryo-electron microscopy and 3-D reconstruction of viruses. Methods Mol Biol
1117:401–443. doi:10.1007/978-1-62703-776-1_19.24357374
-
J.
Voss,
M.
Vaney,
S.
Duquerroy,
C.
Vonrhein,
C.
Girard-Blanc,
Elodie
Crublet,
A.
Thompson,
G.
Bricogne,
F.
Rey
(2010)
Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
Nature, 468
-
S.
Scheres
(2012)
RELION: Implementation of a Bayesian approach to cryo-EM structure determination
Journal of Structural Biology, 180
-
F.
Guo,
Wen
Jiang
(2014)
Single particle cryo-electron microscopy and 3-D reconstruction of viruses.
Methods in molecular biology, 1117
-
W.
Akahata,
G.
Nabel
(2012)
A Specific Domain of the Chikungunya Virus E2 Protein Regulates Particle Formation in Human Cells: Implications for Alphavirus Vaccine Design
Journal of Virology, 86
-
(ClemensJ, MoorthyV
2016
Implementation of RTS,S/AS01 malaria vaccine: the need for further evidence. N Engl J Med
374:2596–2597. doi:10.1056/NEJMe1606007.27355540)
ClemensJ, MoorthyV
2016
Implementation of RTS,S/AS01 malaria vaccine: the need for further evidence. N Engl J Med
374:2596–2597. doi:10.1056/NEJMe1606007.27355540
ClemensJ, MoorthyV
2016
Implementation of RTS,S/AS01 malaria vaccine: the need for further evidence. N Engl J Med
374:2596–2597. doi:10.1056/NEJMe1606007.27355540, ClemensJ, MoorthyV
2016
Implementation of RTS,S/AS01 malaria vaccine: the need for further evidence. N Engl J Med
374:2596–2597. doi:10.1056/NEJMe1606007.27355540
-
(HallengardD, LumFM, KummererBM, LullaA, LullaV, Garcia-ArriazaJ, FazakerleyJK, RoquesP, Le GrandR, MeritsA, NgLF, EstebanM, LiljestromP
2014
Prime-boost immunization strategies against chikungunya virus. J Virol
88:13333–13343. doi:10.1128/JVI.01926-14.25210177)
HallengardD, LumFM, KummererBM, LullaA, LullaV, Garcia-ArriazaJ, FazakerleyJK, RoquesP, Le GrandR, MeritsA, NgLF, EstebanM, LiljestromP
2014
Prime-boost immunization strategies against chikungunya virus. J Virol
88:13333–13343. doi:10.1128/JVI.01926-14.25210177
HallengardD, LumFM, KummererBM, LullaA, LullaV, Garcia-ArriazaJ, FazakerleyJK, RoquesP, Le GrandR, MeritsA, NgLF, EstebanM, LiljestromP
2014
Prime-boost immunization strategies against chikungunya virus. J Virol
88:13333–13343. doi:10.1128/JVI.01926-14.25210177, HallengardD, LumFM, KummererBM, LullaA, LullaV, Garcia-ArriazaJ, FazakerleyJK, RoquesP, Le GrandR, MeritsA, NgLF, EstebanM, LiljestromP
2014
Prime-boost immunization strategies against chikungunya virus. J Virol
88:13333–13343. doi:10.1128/JVI.01926-14.25210177
-
(AoshiT, CarreroJA, KonjufcaV, KoideY, UnanueER, MillerMJ
2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol
39:417–425. doi:10.1002/eji.200838718.19130474)
AoshiT, CarreroJA, KonjufcaV, KoideY, UnanueER, MillerMJ
2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol
39:417–425. doi:10.1002/eji.200838718.19130474
AoshiT, CarreroJA, KonjufcaV, KoideY, UnanueER, MillerMJ
2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol
39:417–425. doi:10.1002/eji.200838718.19130474, AoshiT, CarreroJA, KonjufcaV, KoideY, UnanueER, MillerMJ
2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen. Eur J Immunol
39:417–425. doi:10.1002/eji.200838718.19130474
-
C.
Whitty
(2011)
The RTS,S malaria vaccine
BMJ : British Medical Journal, 343
-
(KhanF, PorterM, SchwenkR, DeBotM, SaudanP, DuttaS
2015
Head-to-head comparison of soluble versus Qβ VLP circumsporozoite protein vaccines reveals selective enhancement of NANP repeat responses. PLoS One
10:e0142035. doi:10.1371/journal.pone.0142035.26571021)
KhanF, PorterM, SchwenkR, DeBotM, SaudanP, DuttaS
2015
Head-to-head comparison of soluble versus Qβ VLP circumsporozoite protein vaccines reveals selective enhancement of NANP repeat responses. PLoS One
10:e0142035. doi:10.1371/journal.pone.0142035.26571021
KhanF, PorterM, SchwenkR, DeBotM, SaudanP, DuttaS
2015
Head-to-head comparison of soluble versus Qβ VLP circumsporozoite protein vaccines reveals selective enhancement of NANP repeat responses. PLoS One
10:e0142035. doi:10.1371/journal.pone.0142035.26571021, KhanF, PorterM, SchwenkR, DeBotM, SaudanP, DuttaS
2015
Head-to-head comparison of soluble versus Qβ VLP circumsporozoite protein vaccines reveals selective enhancement of NANP repeat responses. PLoS One
10:e0142035. doi:10.1371/journal.pone.0142035.26571021
-
R.
Noad,
P.
Roy
(2003)
Virus-like particles as immunogens.
Trends in microbiology, 11 9
-
(BachmannMF, RohrerUH, KundigTM, BurkiK, HengartnerH, ZinkernagelRM
1993
The influence of antigen organization on B cell responsiveness. Science
262:1448–1451. doi:10.1126/science.8248784.8248784)
BachmannMF, RohrerUH, KundigTM, BurkiK, HengartnerH, ZinkernagelRM
1993
The influence of antigen organization on B cell responsiveness. Science
262:1448–1451. doi:10.1126/science.8248784.8248784
BachmannMF, RohrerUH, KundigTM, BurkiK, HengartnerH, ZinkernagelRM
1993
The influence of antigen organization on B cell responsiveness. Science
262:1448–1451. doi:10.1126/science.8248784.8248784, BachmannMF, RohrerUH, KundigTM, BurkiK, HengartnerH, ZinkernagelRM
1993
The influence of antigen organization on B cell responsiveness. Science
262:1448–1451. doi:10.1126/science.8248784.8248784
-
D.
Hallengärd,
F.
Lum,
B.
Kümmerer,
A.
Lulla,
V.
Lulla,
J.
García-Arriaza,
J.
Fazakerley,
P.
Roques,
R.
Grand,
A.
Merits,
L.
Ng,
M.
Esteban,
P.
Liljeström
(2014)
Prime-Boost Immunization Strategies against Chikungunya Virus
Journal of Virology, 88
-
Hadrien
Peyret,
A.
Gehin,
E.
Thuenemann,
D.
Blond,
Aadil
Turabi,
L.
Beales,
D.
Clarke,
R.
Gilbert,
E.
Fry,
D.
Stuart,
Kris
Holmes,
N.
Stonehouse,
M.
Whelan,
W.
Rosenberg,
G.
Lomonossoff,
D.
Rowlands
(2015)
Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins
PLoS ONE, 10
-
(Bruna-RomeroO, HafallaJC, Gonzalez-AseguinolazaG, SanoG, TsujiM, ZavalaF
2001
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol
31:1499–1502. doi:10.1016/S0020-7519(01)00265-X.11595237)
Bruna-RomeroO, HafallaJC, Gonzalez-AseguinolazaG, SanoG, TsujiM, ZavalaF
2001
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol
31:1499–1502. doi:10.1016/S0020-7519(01)00265-X.11595237
Bruna-RomeroO, HafallaJC, Gonzalez-AseguinolazaG, SanoG, TsujiM, ZavalaF
2001
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol
31:1499–1502. doi:10.1016/S0020-7519(01)00265-X.11595237, Bruna-RomeroO, HafallaJC, Gonzalez-AseguinolazaG, SanoG, TsujiM, ZavalaF
2001
Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int J Parasitol
31:1499–1502. doi:10.1016/S0020-7519(01)00265-X.11595237
-
T.
Aoshi,
B.
Zinselmeyer,
V.
Konjufca,
J.
Lynch,
Xin
Zhang,
Y.
Koide,
Mark
Miller
(2008)
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells.
Immunity, 29 3
-
(StewartVA, McGrathSM, WalshDS, DavisS, HessAS, WareLA, KesterKE, CummingsJF, BurgeJR, VossG, DelchambreM, GarconN, TangDB, CohenJD, HeppnerDGJr
2006
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A. Vaccine
24:6483–6492. doi:10.1016/j.vaccine.2006.06.033.16904798)
StewartVA, McGrathSM, WalshDS, DavisS, HessAS, WareLA, KesterKE, CummingsJF, BurgeJR, VossG, DelchambreM, GarconN, TangDB, CohenJD, HeppnerDGJr
2006
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A. Vaccine
24:6483–6492. doi:10.1016/j.vaccine.2006.06.033.16904798
StewartVA, McGrathSM, WalshDS, DavisS, HessAS, WareLA, KesterKE, CummingsJF, BurgeJR, VossG, DelchambreM, GarconN, TangDB, CohenJD, HeppnerDGJr
2006
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A. Vaccine
24:6483–6492. doi:10.1016/j.vaccine.2006.06.033.16904798, StewartVA, McGrathSM, WalshDS, DavisS, HessAS, WareLA, KesterKE, CummingsJF, BurgeJR, VossG, DelchambreM, GarconN, TangDB, CohenJD, HeppnerDGJr
2006
Pre-clinical evaluation of new adjuvant formulations to improve the immunogenicity of the malaria vaccine RTS,S/AS02A. Vaccine
24:6483–6492. doi:10.1016/j.vaccine.2006.06.033.16904798
-
(AkahataW, NabelGJ
2012
A specific domain of the chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol
86:8879–8883. doi:10.1128/JVI.00370-12.22647698)
AkahataW, NabelGJ
2012
A specific domain of the chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol
86:8879–8883. doi:10.1128/JVI.00370-12.22647698
AkahataW, NabelGJ
2012
A specific domain of the chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol
86:8879–8883. doi:10.1128/JVI.00370-12.22647698, AkahataW, NabelGJ
2012
A specific domain of the chikungunya virus E2 protein regulates particle formation in human cells: implications for alphavirus vaccine design. J Virol
86:8879–8883. doi:10.1128/JVI.00370-12.22647698
-
(World Health Organization. 2015
World malaria report 2015. World Health Organization, Geneva, Switzerland
http://www.who.int/malaria/publications/world-malaria-report-2015/en/.)
World Health Organization. 2015
World malaria report 2015. World Health Organization, Geneva, Switzerland
http://www.who.int/malaria/publications/world-malaria-report-2015/en/.
World Health Organization. 2015
World malaria report 2015. World Health Organization, Geneva, Switzerland
http://www.who.int/malaria/publications/world-malaria-report-2015/en/., World Health Organization. 2015
World malaria report 2015. World Health Organization, Geneva, Switzerland
http://www.who.int/malaria/publications/world-malaria-report-2015/en/.
-
A.
Roldão,
M.
Mellado,
L.
Castilho,
M.
Carrondo,
P.
Alves
(2010)
Virus-like particles in vaccine development
Expert Review of Vaccines, 9
-
Caitlin
Sedwick,
A.
Altman
(2002)
Ordered Just So: Lipid Rafts and Lymphocyte Function
Science's STKE, 2002
-
M.
Saxena,
T.
Van,
Fiona
Baird,
P.
Coloe,
P.
Smooker
(2013)
Pre-existing immunity against vaccine vectors – friend or foe?
Microbiology, 159
-
(SedwickCE, AltmanA
2002
Ordered just so: lipid rafts and lymphocyte function. Sci STKE
2002:re2.11880687)
SedwickCE, AltmanA
2002
Ordered just so: lipid rafts and lymphocyte function. Sci STKE
2002:re2.11880687
SedwickCE, AltmanA
2002
Ordered just so: lipid rafts and lymphocyte function. Sci STKE
2002:re2.11880687, SedwickCE, AltmanA
2002
Ordered just so: lipid rafts and lymphocyte function. Sci STKE
2002:re2.11880687
-
S.
Selvarajah,
Nicole
Sexton,
Kristen
Kahle,
Rachel
Fong,
Kimberly
Mattia,
J.
Gardner,
K.
Lu,
Nathan
Liss,
B.
Salvador,
David
Tucker,
Trevor
Barnes,
Manu
Mabila,
Xiangdong
Zhou,
G.
Rossini,
J.
Rucker,
D.
Sanders,
A.
Suhrbier,
V.
Sambri,
A.
Michault,
M.
Muench,
B.
Doranz,
G.
Simmons
(2013)
A Neutralizing Monoclonal Antibody Targeting the Acid-Sensitive Region in Chikungunya Virus E2 Protects from Disease
PLoS Neglected Tropical Diseases, 7
-
(BruneKD, LeneghanDB, BrianIJ, IshizukaAS, BachmannMF, DraperSJ, BiswasS, HowarthM
2016
Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization. Sci Rep
6:19234. doi:10.1038/srep19234.26781591)
BruneKD, LeneghanDB, BrianIJ, IshizukaAS, BachmannMF, DraperSJ, BiswasS, HowarthM
2016
Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization. Sci Rep
6:19234. doi:10.1038/srep19234.26781591
BruneKD, LeneghanDB, BrianIJ, IshizukaAS, BachmannMF, DraperSJ, BiswasS, HowarthM
2016
Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization. Sci Rep
6:19234. doi:10.1038/srep19234.26781591, BruneKD, LeneghanDB, BrianIJ, IshizukaAS, BachmannMF, DraperSJ, BiswasS, HowarthM
2016
Plug-and-display: decoration of virus-like particles via isopeptide bonds for modular immunization. Sci Rep
6:19234. doi:10.1038/srep19234.26781591
-
C.
Nowosad,
K.
Spillane,
P.
Tolar
(2016)
Germinal center B cells recognize antigen through a specialized immune synapse architecture
Nature immunology, 17
-
M.
Sourisseau,
C.
Schilte,
N.
Casartelli,
Céline
Trouillet,
F.
Guivel-Benhassine,
D.
Rudnicka,
N.
Sol-Foulon,
K.
Roux,
M.
Prevost,
H.
Fsihi,
M.
Frenkiel,
Fabien
Blanchet,
Philippe
Afonso,
P.
Ceccaldi,
S.
Ozden,
A.
Gessain,
I.
Schuffenecker,
B.
Verhasselt,
Alessia
Zamborlini,
A.
Saïb,
F.
Rey,
F.
Arenzana‐Seisdedos,
P.
Desprès,
A.
Michault,
M.
Albert,
O.
Schwartz
(2007)
Characterization of Reemerging Chikungunya Virus
PLoS Pathogens, 3
-
(NowosadCR, SpillaneKM, TolarP
2016
Germinal center B cells recognize antigen through a specialized immune synapse architecture. Nat Immunol
17:870–877. doi:10.1038/ni.3458.27183103)
NowosadCR, SpillaneKM, TolarP
2016
Germinal center B cells recognize antigen through a specialized immune synapse architecture. Nat Immunol
17:870–877. doi:10.1038/ni.3458.27183103
NowosadCR, SpillaneKM, TolarP
2016
Germinal center B cells recognize antigen through a specialized immune synapse architecture. Nat Immunol
17:870–877. doi:10.1038/ni.3458.27183103, NowosadCR, SpillaneKM, TolarP
2016
Germinal center B cells recognize antigen through a specialized immune synapse architecture. Nat Immunol
17:870–877. doi:10.1038/ni.3458.27183103
-
(GalfreG, MilsteinC
1981
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol
73:3–46. doi:10.1016/0076-6879(81)73054-4.7300683)
GalfreG, MilsteinC
1981
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol
73:3–46. doi:10.1016/0076-6879(81)73054-4.7300683
GalfreG, MilsteinC
1981
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol
73:3–46. doi:10.1016/0076-6879(81)73054-4.7300683, GalfreG, MilsteinC
1981
Preparation of monoclonal antibodies: strategies and procedures. Methods Enzymol
73:3–46. doi:10.1016/0076-6879(81)73054-4.7300683
-
C.
Suloway,
J.
Pulokas,
D.
Fellmann,
A.
Cheng,
Francisco
Guerra,
J.
Quispe,
S.
Stagg,
C.
Potter,
B.
Carragher
(2005)
Automated molecular microscopy: the new Leginon system.
Journal of structural biology, 151 1
-
(MoorthyVS, BallouWR
2009
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. Malar J
8:312. doi:10.1186/1475-2875-8-312.20042088)
MoorthyVS, BallouWR
2009
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. Malar J
8:312. doi:10.1186/1475-2875-8-312.20042088
MoorthyVS, BallouWR
2009
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. Malar J
8:312. doi:10.1186/1475-2875-8-312.20042088, MoorthyVS, BallouWR
2009
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data. Malar J
8:312. doi:10.1186/1475-2875-8-312.20042088
-
T.
Aoshi,
Javier
Carrero,
V.
Konjufca,
Y.
Koide,
E.
Unanue,
Mark
Miller
(2009)
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen
European Journal of Immunology, 39
-
J.
Regules,
J.
Cummings,
C.
Ockenhouse
(2011)
The RTS,S vaccine candidate for malaria
Expert Review of Vaccines, 10
-
(AkahataW, YangZY, AndersenH, SunS, HoldawayHA, KongWP, LewisMG, HiggsS, RossmannMG, RaoS, NabelGJ
2010
A virus-like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection. Nat Med
16:334–338. doi:10.1038/nm.2105.20111039)
AkahataW, YangZY, AndersenH, SunS, HoldawayHA, KongWP, LewisMG, HiggsS, RossmannMG, RaoS, NabelGJ
2010
A virus-like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection. Nat Med
16:334–338. doi:10.1038/nm.2105.20111039
AkahataW, YangZY, AndersenH, SunS, HoldawayHA, KongWP, LewisMG, HiggsS, RossmannMG, RaoS, NabelGJ
2010
A virus-like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection. Nat Med
16:334–338. doi:10.1038/nm.2105.20111039, AkahataW, YangZY, AndersenH, SunS, HoldawayHA, KongWP, LewisMG, HiggsS, RossmannMG, RaoS, NabelGJ
2010
A virus-like particle vaccine for epidemic chikungunya virus protects nonhuman primates against infection. Nat Med
16:334–338. doi:10.1038/nm.2105.20111039
-
(CromptonPD, PierceSK, MillerLH
2010
Advances and challenges in malaria vaccine development. J Clin Invest
120:4168–4178. doi:10.1172/JCI44423.21123952)
CromptonPD, PierceSK, MillerLH
2010
Advances and challenges in malaria vaccine development. J Clin Invest
120:4168–4178. doi:10.1172/JCI44423.21123952
CromptonPD, PierceSK, MillerLH
2010
Advances and challenges in malaria vaccine development. J Clin Invest
120:4168–4178. doi:10.1172/JCI44423.21123952, CromptonPD, PierceSK, MillerLH
2010
Advances and challenges in malaria vaccine development. J Clin Invest
120:4168–4178. doi:10.1172/JCI44423.21123952
-
Sergio
Morales-Hernández,
Nerea
Ugidos-Damboriena,
J.
López-Sagaseta
(2015)
Self-assembling protein nanoparticles in the design of vaccines
Computational and Structural Biotechnology Journal, 14
-
(PeyretH, GehinA, ThuenemannEC, BlondD, El TurabiA, BealesL, ClarkeD, GilbertRJ, FryEE, StuartDI, HolmesK, StonehouseNJ, WhelanM, RosenbergW, LomonossoffGP, RowlandsDJ
2015
Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins. PLoS One
10:e0120751. doi:10.1371/journal.pone.0120751.25830365)
PeyretH, GehinA, ThuenemannEC, BlondD, El TurabiA, BealesL, ClarkeD, GilbertRJ, FryEE, StuartDI, HolmesK, StonehouseNJ, WhelanM, RosenbergW, LomonossoffGP, RowlandsDJ
2015
Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins. PLoS One
10:e0120751. doi:10.1371/journal.pone.0120751.25830365
PeyretH, GehinA, ThuenemannEC, BlondD, El TurabiA, BealesL, ClarkeD, GilbertRJ, FryEE, StuartDI, HolmesK, StonehouseNJ, WhelanM, RosenbergW, LomonossoffGP, RowlandsDJ
2015
Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins. PLoS One
10:e0120751. doi:10.1371/journal.pone.0120751.25830365, PeyretH, GehinA, ThuenemannEC, BlondD, El TurabiA, BealesL, ClarkeD, GilbertRJ, FryEE, StuartDI, HolmesK, StonehouseNJ, WhelanM, RosenbergW, LomonossoffGP, RowlandsDJ
2015
Tandem fusion of hepatitis B core antigen allows assembly of virus-like particles in bacteria and plants with enhanced capacity to accommodate foreign proteins. PLoS One
10:e0120751. doi:10.1371/journal.pone.0120751.25830365
-
(ChackerianB
2007
Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines
6:381–390. doi:10.1586/14760584.6.3.381.17542753)
ChackerianB
2007
Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines
6:381–390. doi:10.1586/14760584.6.3.381.17542753
ChackerianB
2007
Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines
6:381–390. doi:10.1586/14760584.6.3.381.17542753, ChackerianB
2007
Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines
6:381–390. doi:10.1586/14760584.6.3.381.17542753
-
J.
Clemens,
V.
Moorthy
(2016)
Implementation of RTS,S/AS01 Malaria Vaccine--The Need for Further Evidence.
The New England journal of medicine, 374 26
-
(CasaresS, BrumeanuTD, RichieTL
2010
The RTS,S malaria vaccine. Vaccine
28:4880–4894. doi:10.1016/j.vaccine.2010.05.033.20553771)
CasaresS, BrumeanuTD, RichieTL
2010
The RTS,S malaria vaccine. Vaccine
28:4880–4894. doi:10.1016/j.vaccine.2010.05.033.20553771
CasaresS, BrumeanuTD, RichieTL
2010
The RTS,S malaria vaccine. Vaccine
28:4880–4894. doi:10.1016/j.vaccine.2010.05.033.20553771, CasaresS, BrumeanuTD, RichieTL
2010
The RTS,S malaria vaccine. Vaccine
28:4880–4894. doi:10.1016/j.vaccine.2010.05.033.20553771
-
(TangG, PengL, BaldwinPR, MannDS, JiangW, ReesI, LudtkeSJ
2007
EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol
157:38–46. doi:10.1016/j.jsb.2006.05.009.16859925)
TangG, PengL, BaldwinPR, MannDS, JiangW, ReesI, LudtkeSJ
2007
EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol
157:38–46. doi:10.1016/j.jsb.2006.05.009.16859925
TangG, PengL, BaldwinPR, MannDS, JiangW, ReesI, LudtkeSJ
2007
EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol
157:38–46. doi:10.1016/j.jsb.2006.05.009.16859925, TangG, PengL, BaldwinPR, MannDS, JiangW, ReesI, LudtkeSJ
2007
EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol
157:38–46. doi:10.1016/j.jsb.2006.05.009.16859925
-
Franziska
Zabel,
Deepa
Mohanan,
J.
Bessa,
A.
Link,
A.
Fettelschoss,
P.
Saudan,
T.
Kündig,
M.
Bachmann
(2014)
Viral Particles Drive Rapid Differentiation of Memory B Cells into Secondary Plasma Cells Producing Increased Levels of Antibodies
The Journal of Immunology, 192
-
(Lopez-SagasetaJ, MalitoE, RappuoliR, BottomleyMJ
2016
Self-assembling protein nanoparticles in the design of vaccines. Comput Struct Biotechnol J
14:58–68. doi:10.1016/j.csbj.2015.11.001.26862374)
Lopez-SagasetaJ, MalitoE, RappuoliR, BottomleyMJ
2016
Self-assembling protein nanoparticles in the design of vaccines. Comput Struct Biotechnol J
14:58–68. doi:10.1016/j.csbj.2015.11.001.26862374
Lopez-SagasetaJ, MalitoE, RappuoliR, BottomleyMJ
2016
Self-assembling protein nanoparticles in the design of vaccines. Comput Struct Biotechnol J
14:58–68. doi:10.1016/j.csbj.2015.11.001.26862374, Lopez-SagasetaJ, MalitoE, RappuoliR, BottomleyMJ
2016
Self-assembling protein nanoparticles in the design of vaccines. Comput Struct Biotechnol J
14:58–68. doi:10.1016/j.csbj.2015.11.001.26862374
-
(WhitacreDC, EspinosaDA, PetersCJ, JonesJE, TuckerAE, PetersonDL, ZavalaFP, MilichDR
2015
Plasmodium falciparum and P. vivax epitope-focused VLPs elicit sterile immunity to blood stage infections. PLoS One
10:e0124856. doi:10.1371/journal.pone.0124856.25933001)
WhitacreDC, EspinosaDA, PetersCJ, JonesJE, TuckerAE, PetersonDL, ZavalaFP, MilichDR
2015
Plasmodium falciparum and P. vivax epitope-focused VLPs elicit sterile immunity to blood stage infections. PLoS One
10:e0124856. doi:10.1371/journal.pone.0124856.25933001
WhitacreDC, EspinosaDA, PetersCJ, JonesJE, TuckerAE, PetersonDL, ZavalaFP, MilichDR
2015
Plasmodium falciparum and P. vivax epitope-focused VLPs elicit sterile immunity to blood stage infections. PLoS One
10:e0124856. doi:10.1371/journal.pone.0124856.25933001, WhitacreDC, EspinosaDA, PetersCJ, JonesJE, TuckerAE, PetersonDL, ZavalaFP, MilichDR
2015
Plasmodium falciparum and P. vivax epitope-focused VLPs elicit sterile immunity to blood stage infections. PLoS One
10:e0124856. doi:10.1371/journal.pone.0124856.25933001
-
(ScheresSH
2012
RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol
180:519–530. doi:10.1016/j.jsb.2012.09.006.23000701)
ScheresSH
2012
RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol
180:519–530. doi:10.1016/j.jsb.2012.09.006.23000701
ScheresSH
2012
RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol
180:519–530. doi:10.1016/j.jsb.2012.09.006.23000701, ScheresSH
2012
RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol
180:519–530. doi:10.1016/j.jsb.2012.09.006.23000701
-
(LiL, JoseJ, XiangY, KuhnRJ, RossmannMG
2010
Structural changes of envelope proteins during alphavirus fusion. Nature
468:705–708. doi:10.1038/nature09546.21124457)
LiL, JoseJ, XiangY, KuhnRJ, RossmannMG
2010
Structural changes of envelope proteins during alphavirus fusion. Nature
468:705–708. doi:10.1038/nature09546.21124457
LiL, JoseJ, XiangY, KuhnRJ, RossmannMG
2010
Structural changes of envelope proteins during alphavirus fusion. Nature
468:705–708. doi:10.1038/nature09546.21124457, LiL, JoseJ, XiangY, KuhnRJ, RossmannMG
2010
Structural changes of envelope proteins during alphavirus fusion. Nature
468:705–708. doi:10.1038/nature09546.21124457
-
J.
Fox,
Feng
Long,
M.
Edeling,
Hueylie
Lin,
M.
Duijl-Richter,
Rachel
Fong,
Kristen
Kahle,
J.
Smit,
J.
Jin,
G.
Simmons,
B.
Doranz,
J.
Crowe,
D.
Fremont,
M.
Rossmann,
M.
Diamond
(2015)
Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress
Cell, 163
-
F.
Lum,
L.
Ng
(2015)
Cellular and molecular mechanisms of chikungunya pathogenesis.
Antiviral research, 120
-
D.
Whitacre,
Diego
Espinosa,
Cory
Peters,
Joyce
Jones,
A.
Tucker,
D.
Peterson,
F.
Zavala,
D.
Milich
(2015)
P. falciparum and P. vivax Epitope-Focused VLPs Elicit Sterile Immunity to Blood Stage Infections
PLoS ONE, 10
-
(2015)
World malaria report 2015. World Health Organization
-
M.
Bachmann,
U.
Rohrer,
T.
Kündig,
K.
Bürki,
H.
Hengartner,
R.
Zinkernagel
(1993)
The influence of antigen organization on B cell responsiveness.
Science, 262 5138
-
Long
Li,
J.
Jose,
Y.
Xiang,
R.
Kuhn,
M.
Rossmann
(2010)
Structural Changes of Envelope Proteins During Alphavirus Fusion
Nature, 468
-
(ChangLJ, DowdKA, MendozaFH, SaundersJG, SitarS, PlummerSH, YamshchikovG, SarwarUN, HuZ, EnamaME, BailerRT, KoupRA, SchwartzRM, AkahataW, NabelGJ, MascolaJR, PiersonTC, GrahamBS, LedgerwoodJE, VRC 311 Study Team
2014
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet
384:2046–2052. doi:10.1016/S0140-6736(14)61185-5.25132507)
ChangLJ, DowdKA, MendozaFH, SaundersJG, SitarS, PlummerSH, YamshchikovG, SarwarUN, HuZ, EnamaME, BailerRT, KoupRA, SchwartzRM, AkahataW, NabelGJ, MascolaJR, PiersonTC, GrahamBS, LedgerwoodJE, VRC 311 Study Team
2014
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet
384:2046–2052. doi:10.1016/S0140-6736(14)61185-5.25132507
ChangLJ, DowdKA, MendozaFH, SaundersJG, SitarS, PlummerSH, YamshchikovG, SarwarUN, HuZ, EnamaME, BailerRT, KoupRA, SchwartzRM, AkahataW, NabelGJ, MascolaJR, PiersonTC, GrahamBS, LedgerwoodJE, VRC 311 Study Team
2014
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet
384:2046–2052. doi:10.1016/S0140-6736(14)61185-5.25132507, ChangLJ, DowdKA, MendozaFH, SaundersJG, SitarS, PlummerSH, YamshchikovG, SarwarUN, HuZ, EnamaME, BailerRT, KoupRA, SchwartzRM, AkahataW, NabelGJ, MascolaJR, PiersonTC, GrahamBS, LedgerwoodJE, VRC 311 Study Team
2014
Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet
384:2046–2052. doi:10.1016/S0140-6736(14)61185-5.25132507
-
(HendersonR, SaliA, BakerML, CarragherB, DevkotaB, DowningKH, EgelmanEH, FengZ, FrankJ, GrigorieffN, JiangW, LudtkeSJ, MedaliaO, PenczekPA, RosenthalPB, RossmannMG, SchmidMF, SchroderGF, StevenAC, StokesDL, WestbrookJD, WriggersW, YangH, YoungJ, BermanHM, ChiuW, KleywegtGJ, LawsonCL
2012
Outcome of the first electron microscopy validation task force meeting. Structure
20:205–214. doi:10.1016/j.str.2011.12.014.22325770)
HendersonR, SaliA, BakerML, CarragherB, DevkotaB, DowningKH, EgelmanEH, FengZ, FrankJ, GrigorieffN, JiangW, LudtkeSJ, MedaliaO, PenczekPA, RosenthalPB, RossmannMG, SchmidMF, SchroderGF, StevenAC, StokesDL, WestbrookJD, WriggersW, YangH, YoungJ, BermanHM, ChiuW, KleywegtGJ, LawsonCL
2012
Outcome of the first electron microscopy validation task force meeting. Structure
20:205–214. doi:10.1016/j.str.2011.12.014.22325770
HendersonR, SaliA, BakerML, CarragherB, DevkotaB, DowningKH, EgelmanEH, FengZ, FrankJ, GrigorieffN, JiangW, LudtkeSJ, MedaliaO, PenczekPA, RosenthalPB, RossmannMG, SchmidMF, SchroderGF, StevenAC, StokesDL, WestbrookJD, WriggersW, YangH, YoungJ, BermanHM, ChiuW, KleywegtGJ, LawsonCL
2012
Outcome of the first electron microscopy validation task force meeting. Structure
20:205–214. doi:10.1016/j.str.2011.12.014.22325770, HendersonR, SaliA, BakerML, CarragherB, DevkotaB, DowningKH, EgelmanEH, FengZ, FrankJ, GrigorieffN, JiangW, LudtkeSJ, MedaliaO, PenczekPA, RosenthalPB, RossmannMG, SchmidMF, SchroderGF, StevenAC, StokesDL, WestbrookJD, WriggersW, YangH, YoungJ, BermanHM, ChiuW, KleywegtGJ, LawsonCL
2012
Outcome of the first electron microscopy validation task force meeting. Structure
20:205–214. doi:10.1016/j.str.2011.12.014.22325770
-
M.
Kanekiyo,
Chih-Jen
Wei,
H.
Yassine,
P.
McTamney,
J.
Boyington,
J.
Whittle,
Srinivas
Rao,
W.
Kong,
Lingshu
Wang,
G.
Nabel
(2013)
Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies
Nature, 499
-
J.
Mindell,
N.
Grigorieff
(2003)
Accurate determination of local defocus and specimen tilt in electron microscopy.
Journal of structural biology, 142 3
-
(SourisseauM, SchilteC, CasartelliN, TrouilletC, Guivel-BenhassineF, RudnickaD, Sol-FoulonN, Le RouxK, PrevostMC, FsihiH, FrenkielMP, BlanchetF, AfonsoPV, CeccaldiPE, OzdenS, GessainA, SchuffeneckerI, VerhasseltB, ZamborliniA, SaibA, ReyFA, Arenzana-SeisdedosF, DespresP, MichaultA, AlbertML, SchwartzO
2007
Characterization of reemerging chikungunya virus. PLoS Pathog
3:e89. doi:10.1371/journal.ppat.0030089.17604450)
SourisseauM, SchilteC, CasartelliN, TrouilletC, Guivel-BenhassineF, RudnickaD, Sol-FoulonN, Le RouxK, PrevostMC, FsihiH, FrenkielMP, BlanchetF, AfonsoPV, CeccaldiPE, OzdenS, GessainA, SchuffeneckerI, VerhasseltB, ZamborliniA, SaibA, ReyFA, Arenzana-SeisdedosF, DespresP, MichaultA, AlbertML, SchwartzO
2007
Characterization of reemerging chikungunya virus. PLoS Pathog
3:e89. doi:10.1371/journal.ppat.0030089.17604450
SourisseauM, SchilteC, CasartelliN, TrouilletC, Guivel-BenhassineF, RudnickaD, Sol-FoulonN, Le RouxK, PrevostMC, FsihiH, FrenkielMP, BlanchetF, AfonsoPV, CeccaldiPE, OzdenS, GessainA, SchuffeneckerI, VerhasseltB, ZamborliniA, SaibA, ReyFA, Arenzana-SeisdedosF, DespresP, MichaultA, AlbertML, SchwartzO
2007
Characterization of reemerging chikungunya virus. PLoS Pathog
3:e89. doi:10.1371/journal.ppat.0030089.17604450, SourisseauM, SchilteC, CasartelliN, TrouilletC, Guivel-BenhassineF, RudnickaD, Sol-FoulonN, Le RouxK, PrevostMC, FsihiH, FrenkielMP, BlanchetF, AfonsoPV, CeccaldiPE, OzdenS, GessainA, SchuffeneckerI, VerhasseltB, ZamborliniA, SaibA, ReyFA, Arenzana-SeisdedosF, DespresP, MichaultA, AlbertML, SchwartzO
2007
Characterization of reemerging chikungunya virus. PLoS Pathog
3:e89. doi:10.1371/journal.ppat.0030089.17604450
-
G.
Galfrè,
C.
Milstein
(1981)
Preparation of monoclonal antibodies: strategies and procedures.
Methods in enzymology, 73 Pt B
-
(FoxJM, LongF, EdelingMA, LinH, van Duijl-RichterMK, FongRH, KahleKM, SmitJM, JinJ, SimmonsG, DoranzBJ, CroweJEJr, FremontDH, RossmannMG, DiamondMS
2015
Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress. Cell
163:1095–1107. doi:10.1016/j.cell.2015.10.050.26553503)
FoxJM, LongF, EdelingMA, LinH, van Duijl-RichterMK, FongRH, KahleKM, SmitJM, JinJ, SimmonsG, DoranzBJ, CroweJEJr, FremontDH, RossmannMG, DiamondMS
2015
Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress. Cell
163:1095–1107. doi:10.1016/j.cell.2015.10.050.26553503
FoxJM, LongF, EdelingMA, LinH, van Duijl-RichterMK, FongRH, KahleKM, SmitJM, JinJ, SimmonsG, DoranzBJ, CroweJEJr, FremontDH, RossmannMG, DiamondMS
2015
Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress. Cell
163:1095–1107. doi:10.1016/j.cell.2015.10.050.26553503, FoxJM, LongF, EdelingMA, LinH, van Duijl-RichterMK, FongRH, KahleKM, SmitJM, JinJ, SimmonsG, DoranzBJ, CroweJEJr, FremontDH, RossmannMG, DiamondMS
2015
Broadly neutralizing alphavirus antibodies bind an epitope on E2 and inhibit entry and egress. Cell
163:1095–1107. doi:10.1016/j.cell.2015.10.050.26553503
-
(AoshiT, ZinselmeyerBH, KonjufcaV, LynchJN, ZhangX, KoideY, MillerMJ
2008
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Immunity
29:476–486. doi:10.1016/j.immuni.2008.06.013.18760639)
AoshiT, ZinselmeyerBH, KonjufcaV, LynchJN, ZhangX, KoideY, MillerMJ
2008
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Immunity
29:476–486. doi:10.1016/j.immuni.2008.06.013.18760639
AoshiT, ZinselmeyerBH, KonjufcaV, LynchJN, ZhangX, KoideY, MillerMJ
2008
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Immunity
29:476–486. doi:10.1016/j.immuni.2008.06.013.18760639, AoshiT, ZinselmeyerBH, KonjufcaV, LynchJN, ZhangX, KoideY, MillerMJ
2008
Bacterial entry to the splenic white pulp initiates antigen presentation to CD8+ T cells. Immunity
29:476–486. doi:10.1016/j.immuni.2008.06.013.18760639
-
(FoquetL, HermsenCC, van GemertGJ, Van BraeckelE, WeeningKE, SauerweinR, MeulemanP, Leroux-RoelsG
2014
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest
124:140–144. doi:10.1172/JCI70349.24292709)
FoquetL, HermsenCC, van GemertGJ, Van BraeckelE, WeeningKE, SauerweinR, MeulemanP, Leroux-RoelsG
2014
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest
124:140–144. doi:10.1172/JCI70349.24292709
FoquetL, HermsenCC, van GemertGJ, Van BraeckelE, WeeningKE, SauerweinR, MeulemanP, Leroux-RoelsG
2014
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest
124:140–144. doi:10.1172/JCI70349.24292709, FoquetL, HermsenCC, van GemertGJ, Van BraeckelE, WeeningKE, SauerweinR, MeulemanP, Leroux-RoelsG
2014
Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection. J Clin Invest
124:140–144. doi:10.1172/JCI70349.24292709
-
Emily
Plummer,
M.
Manchester
(2010)
Viral nanoparticles and virus‐like particles: platforms for contemporary vaccine design
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology, 3
-
(SaxenaM, VanTT, BairdFJ, ColoePJ, SmookerPM
2013
Preexisting immunity against vaccine vectors: friend or foe?
Microbiology
159:1–11. doi:10.1099/mic.0.049601-0.23175507)
SaxenaM, VanTT, BairdFJ, ColoePJ, SmookerPM
2013
Preexisting immunity against vaccine vectors: friend or foe?
Microbiology
159:1–11. doi:10.1099/mic.0.049601-0.23175507
SaxenaM, VanTT, BairdFJ, ColoePJ, SmookerPM
2013
Preexisting immunity against vaccine vectors: friend or foe?
Microbiology
159:1–11. doi:10.1099/mic.0.049601-0.23175507, SaxenaM, VanTT, BairdFJ, ColoePJ, SmookerPM
2013
Preexisting immunity against vaccine vectors: friend or foe?
Microbiology
159:1–11. doi:10.1099/mic.0.049601-0.23175507
-
(LiX, MooneyP, ZhengS, BoothCR, BraunfeldMB, GubbensS, AgardDA, ChengY
2013
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods
10:584–590. doi:10.1038/nmeth.2472.23644547)
LiX, MooneyP, ZhengS, BoothCR, BraunfeldMB, GubbensS, AgardDA, ChengY
2013
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods
10:584–590. doi:10.1038/nmeth.2472.23644547
LiX, MooneyP, ZhengS, BoothCR, BraunfeldMB, GubbensS, AgardDA, ChengY
2013
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods
10:584–590. doi:10.1038/nmeth.2472.23644547, LiX, MooneyP, ZhengS, BoothCR, BraunfeldMB, GubbensS, AgardDA, ChengY
2013
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods
10:584–590. doi:10.1038/nmeth.2472.23644547
-
N.
Kushnir,
S.
Streatfield,
V.
Yusibov
(2012)
Virus-like particles as a highly efficient vaccine platform: Diversity of targets and production systems and advances in clinical development
Vaccine, 31
-
(SelvarajahS, SextonNR, KahleKM, FongRH, MattiaKA, GardnerJ, LuK, LissNM, SalvadorB, TuckerDF, BarnesT, MabilaM, ZhouX, RossiniG, RuckerJB, SandersDA, SuhrbierA, SambriV, MichaultA, MuenchMO, DoranzBJ, SimmonsG
2013
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. PLoS Negl Trop Dis
7:e2423. doi:10.1371/journal.pntd.0002423.24069479)
SelvarajahS, SextonNR, KahleKM, FongRH, MattiaKA, GardnerJ, LuK, LissNM, SalvadorB, TuckerDF, BarnesT, MabilaM, ZhouX, RossiniG, RuckerJB, SandersDA, SuhrbierA, SambriV, MichaultA, MuenchMO, DoranzBJ, SimmonsG
2013
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. PLoS Negl Trop Dis
7:e2423. doi:10.1371/journal.pntd.0002423.24069479
SelvarajahS, SextonNR, KahleKM, FongRH, MattiaKA, GardnerJ, LuK, LissNM, SalvadorB, TuckerDF, BarnesT, MabilaM, ZhouX, RossiniG, RuckerJB, SandersDA, SuhrbierA, SambriV, MichaultA, MuenchMO, DoranzBJ, SimmonsG
2013
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. PLoS Negl Trop Dis
7:e2423. doi:10.1371/journal.pntd.0002423.24069479, SelvarajahS, SextonNR, KahleKM, FongRH, MattiaKA, GardnerJ, LuK, LissNM, SalvadorB, TuckerDF, BarnesT, MabilaM, ZhouX, RossiniG, RuckerJB, SandersDA, SuhrbierA, SambriV, MichaultA, MuenchMO, DoranzBJ, SimmonsG
2013
A neutralizing monoclonal antibody targeting the acid-sensitive region in chikungunya virus E2 protects from disease. PLoS Negl Trop Dis
7:e2423. doi:10.1371/journal.pntd.0002423.24069479
-
V.
Moorthy,
V.
Moorthy,
W.
Ballou
(2009)
Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data
Malaria Journal, 8
-
A.
Birkett,
K.
Lyons,
Annette
Schmidt,
D.
Boyd,
G.
Oliveira,
A.
Siddique,
R.
Nussenzweig,
J.
Calvo-Calle,
E.
Nardin
(2002)
A Modified Hepatitis B Virus Core Particle Containing Multiple Epitopes of the Plasmodium falciparum Circumsporozoite Protein Provides a Highly Immunogenic Malaria Vaccine in Preclinical Analyses in Rodent and Primate Hosts
Infection and Immunity, 70
-
(ZabelF, MohananD, BessaJ, LinkA, FettelschossA, SaudanP, KundigTM, BachmannMF
2014
Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies. J Immunol
192:5499–5508. doi:10.4049/jimmunol.1400065.24821969)
ZabelF, MohananD, BessaJ, LinkA, FettelschossA, SaudanP, KundigTM, BachmannMF
2014
Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies. J Immunol
192:5499–5508. doi:10.4049/jimmunol.1400065.24821969
ZabelF, MohananD, BessaJ, LinkA, FettelschossA, SaudanP, KundigTM, BachmannMF
2014
Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies. J Immunol
192:5499–5508. doi:10.4049/jimmunol.1400065.24821969, ZabelF, MohananD, BessaJ, LinkA, FettelschossA, SaudanP, KundigTM, BachmannMF
2014
Viral particles drive rapid differentiation of memory B cells into secondary plasma cells producing increased levels of antibodies. J Immunol
192:5499–5508. doi:10.4049/jimmunol.1400065.24821969
-
(CastenLA, PierceSK
1988
Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J Immunol
140:404–410.2447176)
CastenLA, PierceSK
1988
Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J Immunol
140:404–410.2447176
CastenLA, PierceSK
1988
Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J Immunol
140:404–410.2447176, CastenLA, PierceSK
1988
Receptor-mediated B cell antigen processing. Increased antigenicity of a globular protein covalently coupled to antibodies specific for B cell surface structures. J Immunol
140:404–410.2447176
-
O.
Schwartz,
M.
Albert
(2010)
Biology and pathogenesis of chikungunya virus
Nature Reviews Microbiology, 8
-
Ruobing
Wang,
Joseph
Smith,
S.
Kappe
(2009)
Advances and challenges in malaria vaccine development
Expert Reviews in Molecular Medicine, 11
-
B.
Chackerian
(2007)
Virus-like particles: flexible platforms for vaccine development
Expert Review of Vaccines, 6
-
Karl
Brune,
D.
Leneghan,
Iona
Brian,
A.
Ishizuka,
M.
Bachmann,
S.
Draper,
S.
Biswas,
M.
Howarth
(2016)
Plug-and-Display: decoration of Virus-Like Particles via isopeptide bonds for modular immunization
Scientific Reports, 6