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Comparative Study of the Standard Fluorescent Antibody to Membrane Antigen (FAMA) Assay and a Flow Cytometry-Adapted FAMA Assay To Assess Immunity to Varicella-Zoster Virus

Comparative Study of the Standard Fluorescent Antibody to Membrane Antigen (FAMA) Assay and a... A flow cytometry-adapted fluorescent antibody to membrane antigen (FAMA) assay to detect IgG antibodies against varicella-zoster virus (VZV) was developed and tested in 62 serum samples, showing 90.32% accuracy obtained from a receiver operating characteristic (ROC) curve with a 0.9125 (95% confidence interval (CI), 0.829 to 1.00) area below the curve compared to the result with standard FAMA. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Vaccine Immunology American Society For Microbiology

Comparative Study of the Standard Fluorescent Antibody to Membrane Antigen (FAMA) Assay and a Flow Cytometry-Adapted FAMA Assay To Assess Immunity to Varicella-Zoster Virus

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Comparative Study of the Standard Fluorescent Antibody to Membrane Antigen (FAMA) Assay and a Flow Cytometry-Adapted FAMA Assay To Assess Immunity to Varicella-Zoster Virus

Lafer, M. M.; Weckx, L. Y.; de Moraes-Pinto, M. I.; Garretson, A.; Steinberg, S. P.; Gershon, A. A.; LaRussa, P. S.
Clinical and Vaccine Immunology , Volume 18 (7): 1194 – Jul 1, 2011

Abstract

A flow cytometry-adapted fluorescent antibody to membrane antigen (FAMA) assay to detect IgG antibodies against varicella-zoster virus (VZV) was developed and tested in 62 serum samples, showing 90.32% accuracy obtained from a receiver operating characteristic (ROC) curve with a 0.9125 (95% confidence interval (CI), 0.829 to 1.00) area below the curve compared to the result with standard FAMA.

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Publisher
American Society For Microbiology
Copyright
Copyright © 2011 by the American Society For Microbiology.
ISSN
1556-6811
eISSN
1556-679X
DOI
10.1128/CVI.05130-11
Publisher site
See Article on Publisher Site

Abstract

A flow cytometry-adapted fluorescent antibody to membrane antigen (FAMA) assay to detect IgG antibodies against varicella-zoster virus (VZV) was developed and tested in 62 serum samples, showing 90.32% accuracy obtained from a receiver operating characteristic (ROC) curve with a 0.9125 (95% confidence interval (CI), 0.829 to 1.00) area below the curve compared to the result with standard FAMA.

Journal

Clinical and Vaccine Immunology – American Society For Microbiology

Published: Jul 1, 2011

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