Binding of Glucuronoxylomannan to the CD14 Receptor in Human A549 Alveolar Cells Induces Interleukin-8 Production
Barbosa, Fabiane M.; Fonseca, Fernanda L.; Figueiredo, Rodrigo T.; Bozza, Marcelo T.; Casadevall, Arturo;
Clinical and Vaccine Immunology
, Volume 14 (1): 94 – Jan 1, 2007
Abstract
Glucuronoxylomannan (GXM) is the major capsular polysaccharide of Cryptococcus neoformans . GXM receptors have been characterized in phagocytes and endothelial cells, but epithelial molecules recognizing the polysaccharide remain unknown. In the current study, we demonstrate that GXM binds to the CD14 receptor in human type II alveolar epithelial cells, resulting in the production of the proinflammatory chemokine interleukin-8.
