Antibodies to the hepatitis B e antigen (HBeAg) can be induced in HBeAg- transgenic mice by adoptive transfer of a specific T-helper 2 cell clone
Abstract
C Hultgren, DR Milich and M Sallberg Division of Clinical Virology, Huddinge University Hospital, Sweden. Production of antibody to hepatitis B e antigen (HBeAg); i.e., anti-HBe antibody,) in HBeAg-transgenic mice is believed to be mediated by T- helper 2 (Th2) cells. Injection of an HBeAg-specific Th2 clone into HBeAg-transgenic H-2k mice induced anti-HBe antibody production, confirming the function of Th2 cells in this model system.