Abstract

Receive: RSS Feeds, eTOCs, free email alerts (when new articles cite this article), more» Information about commercial reprint orders: http://cvi.asm.org/site/misc/reprints.xhtml To subscribe to to another ASM Journal go to: http://journals.asm.org/site/subscriptions/ CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, Jan. 1994, p. 1-4 Vol. 1, No. I 1071-412X/94/$04.00+0 Copyright © 1994, American Society for Microbiology AMOS ETZIONI* Department of Pediatrics and Clinical Immunology, Rambam Medical Center, and the Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel Received 22 July 1993/Returned for modification 2 August 1993/Accepted 23 August 1993 INTRODUCTION Knowledge of host defense mechanisms has greatly expanded during the last 15 years. In the early 1980s, the subsets of cells involved in the immune response were defined by using monoclonal antibodies. Subsequently, the soluble factors (mainly interleukins) produced by these cells were investigated. During the last 5 years, it was demonstrated that close contact between the cells plays a major role in eliciting host inflammatory responses. This contact is mediated through adhesion molecules which are expressed on the surface of the different cells. Their importance in many biological processes has been recently demonstrated (2, 26, 35). This will focus on the adhesion molecules which are involved in neutrophil-endothelial cell