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Is It Possible to Be Schizophrenic Yet Neuropsychologically Normal?

Is It Possible to Be Schizophrenic Yet Neuropsychologically Normal? This study identified and characterized a group of schizophrenic patients without neuropsychological (NP) impairment. A comprehensive NP battery was administered to 171 schizophrenic outpatients and 63 normal comparison participants. Each participant's NP status was classified through blind clinical ratings by 2 experienced neuropsychologists; 27% of the schizophrenics were classified as NP normal. The NP-normal and NP-impaired schizophrenics were similar in terms of most demographic, psychiatric, and functional characteristics, except that NP-normal patients had less negative and extrapyramidal symptoms, were on less anticholinergic medication, socialized more frequently, and were less likely to have had a recent psychiatric hospitalization. The existence of NP-normal schizophrenics suggests that the pathophysiology underlying the cognitive deficits often associated with schizophrenia may be distinct from that causing some of its core psychiatric features. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png NeuroPsychology American Psychological Association

Is It Possible to Be Schizophrenic Yet Neuropsychologically Normal?

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References (46)

Publisher
American Psychological Association
Copyright
Copyright © 1997 American Psychological Association
ISSN
0894-4105
eISSN
1931-1559
DOI
10.1037/0894-4105.11.3.437
Publisher site
See Article on Publisher Site

Abstract

This study identified and characterized a group of schizophrenic patients without neuropsychological (NP) impairment. A comprehensive NP battery was administered to 171 schizophrenic outpatients and 63 normal comparison participants. Each participant's NP status was classified through blind clinical ratings by 2 experienced neuropsychologists; 27% of the schizophrenics were classified as NP normal. The NP-normal and NP-impaired schizophrenics were similar in terms of most demographic, psychiatric, and functional characteristics, except that NP-normal patients had less negative and extrapyramidal symptoms, were on less anticholinergic medication, socialized more frequently, and were less likely to have had a recent psychiatric hospitalization. The existence of NP-normal schizophrenics suggests that the pathophysiology underlying the cognitive deficits often associated with schizophrenia may be distinct from that causing some of its core psychiatric features.

Journal

NeuroPsychologyAmerican Psychological Association

Published: Jul 1, 1997

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