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Use of Tranquilizers for Mentally Deficient Patients

Use of Tranquilizers for Mentally Deficient Patients Abstract In a recent article by Tarjan et al.1 the use of chlorpromazine in mentally deficient patients was reviewed, possible complications from its use were well outlined, and the need for a double-blind research study to measure its objective effectiveness was indicated. Timberlake et al.2 reported a double-blind study on the effects of reserpine on 200 mentally retarded children. These authors felt that the two-month period of treatment with the drug followed by two-months' use of a placebo was "too brief to determine how well improvement will be sustained."2 They did not attempt to compare the effectiveness of chlorpromazine with that of reserpine. The comparative drug study by Sprogis et al.3 did not utilize the doubleblind technique but did suggest that, while reserpine appeared more effective initially, chlorpromazine appeared to have a more-lasting effect after the drugs had been withdrawn. They suggested the use of a combination References 1. Tarjan, G.; Lowery, V. E., and Wright, S. W.: Use of Chlorpromazine in 278 Mentally Deficient Patients , A. M. A. J. Dis. Child. 94: 294 ( (Sept.) ) 1957. 2. Timberlake, W. H.; Belmont, E. H., and Ognik, J.: The Effect of Reserpine in 200 Mentally Retarded Children , Am. J. Ment. Deficiency 62:61 ( (July) ) 1957. 3. Sprogis, G. R.; Lezdins, V.; White, S. D.; Ming, C.; Lanning, M.; Drake, M. E., and Wyckoff, G.: Comparative Study on Thorazine and Serpasil in the Mental Defective , Am. J. Ment. Deficiency 61:737 ( (April) ) 1957. 4. Bair, H. V., and Herold, W.: Efficacy of Chlorpromazine in Hyperactive Mentally Retarded Children , A. M. A. Arch. Neurol. & Psychiat. 74:363 ( (Oct.) ) 1955. 5. Esen, F. M., and Durling, D.: Thorazine in the Treatment of Mentally Retarded Children , Arch. Pediat. 73:168 ( (May) ) 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Use of Tranquilizers for Mentally Deficient Patients

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060060161005
Publisher site
See Article on Publisher Site

Abstract

Abstract In a recent article by Tarjan et al.1 the use of chlorpromazine in mentally deficient patients was reviewed, possible complications from its use were well outlined, and the need for a double-blind research study to measure its objective effectiveness was indicated. Timberlake et al.2 reported a double-blind study on the effects of reserpine on 200 mentally retarded children. These authors felt that the two-month period of treatment with the drug followed by two-months' use of a placebo was "too brief to determine how well improvement will be sustained."2 They did not attempt to compare the effectiveness of chlorpromazine with that of reserpine. The comparative drug study by Sprogis et al.3 did not utilize the doubleblind technique but did suggest that, while reserpine appeared more effective initially, chlorpromazine appeared to have a more-lasting effect after the drugs had been withdrawn. They suggested the use of a combination References 1. Tarjan, G.; Lowery, V. E., and Wright, S. W.: Use of Chlorpromazine in 278 Mentally Deficient Patients , A. M. A. J. Dis. Child. 94: 294 ( (Sept.) ) 1957. 2. Timberlake, W. H.; Belmont, E. H., and Ognik, J.: The Effect of Reserpine in 200 Mentally Retarded Children , Am. J. Ment. Deficiency 62:61 ( (July) ) 1957. 3. Sprogis, G. R.; Lezdins, V.; White, S. D.; Ming, C.; Lanning, M.; Drake, M. E., and Wyckoff, G.: Comparative Study on Thorazine and Serpasil in the Mental Defective , Am. J. Ment. Deficiency 61:737 ( (April) ) 1957. 4. Bair, H. V., and Herold, W.: Efficacy of Chlorpromazine in Hyperactive Mentally Retarded Children , A. M. A. Arch. Neurol. & Psychiat. 74:363 ( (Oct.) ) 1955. 5. Esen, F. M., and Durling, D.: Thorazine in the Treatment of Mentally Retarded Children , Arch. Pediat. 73:168 ( (May) ) 1956.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Aug 1, 1958

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