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Treatment of Corneal Abrasion with Topical Whole Blood

Treatment of Corneal Abrasion with Topical Whole Blood Abstract One of the most common injuries of the eye is corneal abrasion, a loss of epithelium from Bowman's membrane. Although a small abrasion may heal within 12 hours, a large one may incapacitate the patient for several days because of intense pain, photophobia, and lacrimation. Furthermore, if healing is delayed, secondary infection may lead to ulceration, with permanent scarring and visual impairment. Many chemical and physical agents have been proposed to stimulate wound healing but most have proved to be of little benefit. Of those showing promise, nearly all are biological products or derivatives. Schaeffer (1944) observed an increased rate of corneal epithelization in abraded eyes treated with buffered amino acids. Moorhead (1943) used red cell concentrates for surgical wound dressing, and Newell (1947) used red cell concentrates mixed in ointment base to promote corneal epithelization. Although ointments are soothing to painful, denuded corneas, they delay healing and are suspected References 1. Schaeffer, A. J.: Effects of Certain Amino Acids on Healing of Experimental Wounds of Cornea , Proc. Soc. Exper. Biol. & Med. 61:165, 1944. 2. Moorhead, J. J., and Unger, L. J.: Human Red Cell Concentrates for Surgical Dressings , Am. J. Surg. 59:104, 1943. 3. Newell, F. W.: Stimulation of Corneal Epithelization with Topical Application of Erythrocytes: Experimental Study , Am. J. Ophth. 30:1238-1243, 1947. 4. Heerema, J. C., and Friedenwald, J. S.: Retardation of Wound Healing in Corneal Epithelium by Lanolin , Am. J. Ophth. 33:1421-1427, 1950. 5. Parry, T. G. W., and Laszlo, G. C.: Thrombin Technique in Ophthalmic Surgery , Brit. J. Ophth. 30:176-178, 1946. 6. Toulant, P.; Larmande, A., and Toulant, M.: Instillations of Fresh Blood in Therapy of Burns of Cornea , Bull. Acad. nat. méd. 135:279-281, 1951. 7. Rigg, J. P., and Rigg, R. W.: Corneal Healing , Am. J. Ophth. 48:238-252 (Sept., (Pt. 2) ) 1959. 8. Weisser, C. W.: Fibrin Film Treatment of Corneal Diseases , A.M.A. Arch. Ophth. 51:681, 1954. 9. Cuendet, J. F., and Michels, V.: Use of Fibrin Films in Treatment of Keratitis , Ophthalmologica 127:301, 1954. 10. Marr, W. G.; Wood, R., and Grieves, M.: Further Studies on the Effect of Agents on Regeneration of Corneal Epithelium , Am. J. Ophth. 37:544, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Treatment of Corneal Abrasion with Topical Whole Blood

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1960.00950020950009
Publisher site
See Article on Publisher Site

Abstract

Abstract One of the most common injuries of the eye is corneal abrasion, a loss of epithelium from Bowman's membrane. Although a small abrasion may heal within 12 hours, a large one may incapacitate the patient for several days because of intense pain, photophobia, and lacrimation. Furthermore, if healing is delayed, secondary infection may lead to ulceration, with permanent scarring and visual impairment. Many chemical and physical agents have been proposed to stimulate wound healing but most have proved to be of little benefit. Of those showing promise, nearly all are biological products or derivatives. Schaeffer (1944) observed an increased rate of corneal epithelization in abraded eyes treated with buffered amino acids. Moorhead (1943) used red cell concentrates for surgical wound dressing, and Newell (1947) used red cell concentrates mixed in ointment base to promote corneal epithelization. Although ointments are soothing to painful, denuded corneas, they delay healing and are suspected References 1. Schaeffer, A. J.: Effects of Certain Amino Acids on Healing of Experimental Wounds of Cornea , Proc. Soc. Exper. Biol. & Med. 61:165, 1944. 2. Moorhead, J. J., and Unger, L. J.: Human Red Cell Concentrates for Surgical Dressings , Am. J. Surg. 59:104, 1943. 3. Newell, F. W.: Stimulation of Corneal Epithelization with Topical Application of Erythrocytes: Experimental Study , Am. J. Ophth. 30:1238-1243, 1947. 4. Heerema, J. C., and Friedenwald, J. S.: Retardation of Wound Healing in Corneal Epithelium by Lanolin , Am. J. Ophth. 33:1421-1427, 1950. 5. Parry, T. G. W., and Laszlo, G. C.: Thrombin Technique in Ophthalmic Surgery , Brit. J. Ophth. 30:176-178, 1946. 6. Toulant, P.; Larmande, A., and Toulant, M.: Instillations of Fresh Blood in Therapy of Burns of Cornea , Bull. Acad. nat. méd. 135:279-281, 1951. 7. Rigg, J. P., and Rigg, R. W.: Corneal Healing , Am. J. Ophth. 48:238-252 (Sept., (Pt. 2) ) 1959. 8. Weisser, C. W.: Fibrin Film Treatment of Corneal Diseases , A.M.A. Arch. Ophth. 51:681, 1954. 9. Cuendet, J. F., and Michels, V.: Use of Fibrin Films in Treatment of Keratitis , Ophthalmologica 127:301, 1954. 10. Marr, W. G.; Wood, R., and Grieves, M.: Further Studies on the Effect of Agents on Regeneration of Corneal Epithelium , Am. J. Ophth. 37:544, 1954.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Jun 1, 1960

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