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R. Slater (1954)
Investigation of an infant born of a mother suffering from cirrhosis of the liver.Pediatrics, 13 4
George Cartwright, C. Gubler, J. Bush, M. Wintrobe (1956)
Studies on Copper Metabolism: XVII. Further Observations on the Anemia of Copper Deficiency in SwineBlood, 11
A. Wiener (1951)
THE HALF-LIFE OF PASSIVELY ACQUIRED ANTIBODY GLOBULIN MOLECULES IN INFANTSThe Journal of Experimental Medicine, 94
I. J. Drekter , S. Pearson, E. Bartczak (1947)
A Rapid Method for the Determination of Total 17-KetosteroidsJ. Clin. Endocrinol., 7
V. Bleisch, H. Shwachman (1954)
Serum cholinesterase values in childhood in health and disease.Pediatrics, 13 5
R. Ely, R. Raile, P. Bray, V. Kelley (1954)
Studies of 17-hydroxycorticosteroids. IV. Evaluation of a standard ACTH-17-hydroxycorticosteroid response test in children.Pediatrics, 13 5
O. Orlandini, A. Sass-kortsak, Ebbs Jh (1955)
Serum gamma globulin levels in normal infants.Pediatrics, 16 5
C. Fried, W. Henley (1954)
Deficiency in gamma globulin with edema and hypoproteinemia.Pediatrics, 14 1
H. B. Burch , O. H. Lowry (1946)
Vitamin Methods, 1
J. Bound, W. Hackett (1953)
Idiopathic Hypoproteinaemic Oedema and Aminoaciduria in an InfantArchives of Disease in Childhood, 28
W. H. Thompson , M. R. Zeigler (1932)
A Comparative Study of the Inorganic Metabolism in Nephrosis and in Edema of Undetermined OriginAm. J. Dis. Child., 44
Reddy Wj (1954)
Modification of the Reddy-Jenkins-Thorn method for the estimation of 17-hydroxycorticoids in urine.Metabolism-clinical and Experimental, 3
W. Thompson, I. Mcquarrie, E. Bell (1936)
Edema associated with hypogenesis of serum proteins and atrophic changes in the liverThe Journal of Pediatrics, 9
C. E. Rath (1949)
Chemical, Clinical, and Immunological Studies on Products of Human Plasma Fractionation: Serum Iron TransportJ. Clin. Invest., 28
G. Cartwright (1947)
Dietary factors concerned in erythropoiesis.Blood, 2 2
R. Kaye, R. Caughey, W. Mccrory (1954)
Effects of vitamin B12 and aureo mycin on nitrogen retention in infants.Pediatrics, 13 5
E. Reifenstein, Fuller Albright, Shirley Wells (1945)
The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus, and nitrogen.The Journal of clinical endocrinology and metabolism, 5
A. Altmann, J. Murray (1948)
The anaemia of malignant malnutrition; infantile pellagra, kwashiorkor; protein deficiency as a possible aetiological factor.The South African journal of medical sciences, 13 3
R. Good (1954)
Agammaglobulinemia-a provocative experiment of nature, 26
V. Kelley, M. Ziegler, D. Doeden, I. Mcquarrie (1950)
Labeled Methionine as an Indicator of Protein formation in Children with Lipoid Nephrosis.∗Proceedings of the Society for Experimental Biology and Medicine, 75
Don Nelson, Leo Samuels (1952)
A method for the determination of 17-hydroxycorticosteroids in blood; 17-hydroxycorticosterone in the peripheral circulation.The Journal of clinical endocrinology and metabolism, 12 5
B. Schick, J. Greenbaum (1945)
Edema with hypoproteinemia due to a congenital defect in protein formationThe Journal of Pediatrics, 27
J. Bush (1956)
The role of trace elements in hemopoiesis and in the therapy of anemia.Pediatrics, 17 4
C. Gubler, M. Lahey, H. Ashenbrucker, G. Cartwright, M. Wintrobe (1952)
Studies on copper metabolism I. A method for the determination of copper in whole blood, red blood cells, and plasma.The Journal of biological chemistry, 196 1
N. Talbot, A. Butler, E. Maclachlan (1943)
THE EFFECT OF TESTOSTERONE AND ALLIED COMPOUNDS ON THE MINERAL, NITROGEN, AND CARBOHYDRATE METABOLISM OF A GIRL WITH ADDISON'S DISEASE.The Journal of clinical investigation, 22 4
D.: in Gitlin (1956)
The Year Book of Pediatrics, 1955-1956
S. Keidan, K. Mccarthy, J. Haworth (1953)
Fatal Generalized Vaccinia with Failure of Antibody Production and Absence of Serum Gamma GlobulinArchives of Disease in Childhood, 28
J. Wyngaarden, J. Crawford, H. Chamberlin, W. Lever (1952)
Idiopathic hypoproteinemia; report of a case of transient edema, depression of plasma albumin and gamma globulin and eosinophilia.Pediatrics, 9 6
Charles Rath, Clement Finch (1949)
CHEMICAL, CLINICAL, AND IMMUNOLOGICAL STUDIES ON THE PRODUCTS OF HUMAN PLASMA FRACTIONATION. XXXVIII. SERUM IRON TRANSPORT. MEASUREMENT OF IRON-BINDING CAPACITY OF SERUM IN MAN.The Journal of clinical investigation, 28 1
F. Scoular (1939)
A quantitative study by means of spectrographic analysis of aluminum in nutrition.Journal of Nutrition, 16
M. Grinstein, M. Wintrobe (1948)
Spectrophotometric micromethod for the quantitative determination of the free erythrocyte protoporphyrin.The Journal of biological chemistry, 172 2
L. Corbeel , H. Malbrain (1954)
L'hypoprotéinémie essentielle chez l'enfantActa pediat. belg., 6
M. Wilson, B. Pringle (1954)
Experimental studies of the agar-plate precipitin test of Ouchterlony.Journal of immunology, 73 4
Abstract Within an 18-month period four infants have been seen with the unusual clinical findings of edema, pallor, and marked irritability. Preliminary laboratory studies have demonstrated hypoproteinemia and anemia in the absence of other signs of hepatic or renal disease in each patient. Although similar clinical situations have been discussed previously in pediatric writings,* none of the reported patients appears to have had the same clinical syndrome as those to be described here. For this reason the clinical findings in the four patients will be presented in some detail, and the many laboratory investigations undertaken in an attempt to define pathogenesis of the hypoproteinemia and anemia will be discussed. Report of Cases Case 1.—This Caucasian girl was born on Nov. 15, 1953, after an uneventful pregnancy and normal labor. Her birth weight was 3600 gm. (7 lb. 15 oz.). She was first seen in the Department of Pediatrics of the University References 1. Schick, B., and Greenbaum, J. W.: Edema with Hypoproteinemia Due to Congenital Defect in Protein Formation , J. Pediat. 27:241, 1945.Crossref 2. Fried C. T., and Henley, W. L.: Deficiency in Gamma Globulin with Edema and Hypoproteinemia , Pediatrics 14:59, 1954. 3. Wyngaarden, J. B.; Crawford, J. D.; Chamberlin, H. R., and Lever, W. F.: Idiopathic Hypoproteinemia: Report of Case of Transient Edema, Depression of Plasma Albumin and Gamma Globulin and Eosinophilia , Pediatrics 9:729, 1952. 4. Corbeel, L.; Malbrain, H., and De Visscher, M.: L'hypoprotéinémie essentielle chez l'enfant , Acta pediat. belg. 6:337, 1954. 5. Bound, J. P., and Hackett, W. R.: Idiopathic Hypoproteinaemic Oedema and Amino-Aciduria in an Infant , Arch. Dis. Childhood 28:104, 1953.Crossref 6. Bleisch, V. R., and Shwachman, H.: Serum Cholinesterase Values in Childhood in Health and Disease , Pediatrics 13:426, 1954. 7. Thompson, W. H.; Zeigler, M. R., and McQuarrie, I.: A Comparative Study of the Inorganic Metabolism in Nephrosis and in Edema of Undetermined Origin , Am. J. Dis. Child. 44:650, 1932. 8. Thompson, W. H.; McQuarrie, I., and Bell, E. T.: Edema Associated with Hypogenesis of Serum Proteins and Atrophic Changes in the Liver , J. Pediat. 9:604, 1936.Crossref 9. Ely, R. S.; Raile, R. B.; Bray, P. F., and Kelly, V. C.: Studies of 17-Hydroxycorticosteroids: IV. Evaluation of a Standard ACTH 17-Hydroxycorticosteroid Response Test in Children , Pediatrics 13:403, 1954. 10. Reddy, W. J.: Modification of the Reddy-Jenkins-Thorn Method for the Estimation of 17-Hydroxycorticoids in Urine , Metabolism 3:489, 1952. 11. Nelson, D. H., and Samuels, L. T.: A Method for the Determination of 17-Hydroxycorticosteroids in Blood: 17-Hydroxycortiscosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519, 1952.Crossref 12. Drekter, I. J.; Pearson, S.; Bartczak, E., and McGavack, T. H.: A Rapid Method for the Determination of Total 17-Ketosteroids , J. Clin. Endocrinol. 7:795, 1947.Crossref 13. Kingsley, G. R.; Reinhold, J. G., and Weichselbaum, T. E.: Total Protein, Albumin, Globulin, in Standard Methods of Clinical Chemistry, edited by M. Reiner, Vol. 1, p. 88. 1953. 14. Gitlin, D.: in The Year Book of Pediatrics, 1955-1956 , edited by Sidney S. Gellis, Chicago, Year Book Publishers, Inc. 1956, p. 51. 15. Orlandini, O. T.; Sass-Kortsak, A., and Ebbs, J. H.: Serum Gamma Globulin Levels in Normal Infants , Pediatrics 16:575, 1955. 16. Slater, R. J.: Investigation of an Infant Born of a Mother Suffering from Cirrhosis of the Liver , Pediatrics 13:308, 1954. 17. Wiener, A. S.: The Half-Life of Passively Acquired Antibody Globulin Molecules in Infants , J. Exper. Med. 94:213, 1951.Crossref 18. Keidan, S. E.; McCarthy, K., and Haworth, J. C.: Fatal Generalized Vaccinia with Failure of Antibody Production and Absence of Serum Gamma Globulin , Arch. Dis. Childhood 28:110, 1953.Crossref 19. Ulstrom, R. A.; Smith, N. J.; Nakamura, K., and Heimlich, E.: Transient Dysproteinemia in Infants: II. Studies of Protein Metabolism Using Amino Acid Isotopes, to be published. 20. Reifenstein, E. C., Jr.; Albright, F., and Wells, S. L.: The Accumulation, Interpretation, and Presentation of Data Pertaining to Metabolic Balances, Notably Those of Calcium, Phosphorus, and Nitrogen , J. Clin. Endocrinol. 5:367-95, 1945;Crossref 21. Correction 6:232, 1946. 22. Talbot, N. B.; Butler, A. M., and Mac-Lachland, E. A.: The Effect of Testosterone and Allied Compounds on the Mineral, Nitrogen, and Carbohydrate Metabolism of a Girl with Addison's Disease , J. Clin. Invest. 22:583, 1943.Crossref 23. Kaye, R.; Caughey, R. H., and McCrory, W. W.: Effects of Vitamin B12 and Aureomycin on Nitrogen Retention in Infants , Pediatrics 13:462, 1954. 24. Kelley, V. C.; Ziegler, M. R.; Doeden, D., and McQuarrie, I.: Labeled Methionine as an Indicator of Protein Formation in Children with Lipoid Nephrosis , Proc. Soc. Exper. Biol. & Med. 75:153, 1950. 25. Wilson, M. W., and Pringle, B. H.: Experimental Studies of the Agar-Plate Precipitin Test of Ouchterlony , J. Immunol. 73:232, 1954. 26. Rath, C. E., and Finch, C. A.: Chemical, Clinical, and Immunological Studies on Products of Human Plasma Fractionation: Serum Iron Transport; Measurement of Iron Binding Capacity of Serum in Man , J. Clin. Invest. 28:79, 1949.Crossref 27. Gubler, C. J.; Lahey, M. E.; Ashenbrucker, H.; Cartwright, G. E., and Wintrobe, M. M.: Studies on Copper Metabolism: I. A Method for Determination of Copper in Whole Blood, Red Blood Cells, and Plasma , J. Biol. Chem. 196:209, 1952. 28. Burch, H. B.; Lowry, O. H., and Bessey, O. A.: Vitamin Methods , Vol. 1, New York, Academic Press, 1946, pp. 317-320. 29. Grinstein, M., and Wintrobe, M.: Spectrophotometric Micromethod for the Quantitative Determination of Free Erythrocyte Protoporphyrin , J. Biol. Chem. 172:459, 1948. 30. Schulz, J., and Smith, N. J.: Quantitative Determination of the Absorption of Iron from Food, Twenty-Sixth Meeting of the Society for Pediatric Research, Buck Hill Falls, Pa., 1956. 31. Good, R. A.: Agammaglobulinemia: II. An Experimental Study, read before the Combined 32. Meeting of the American Pediatric Society, British Paediatric Association, The Society for Pediatric Research, and the Canadian Paediatric Society—Société Canadienne de Pédiatrie, Quebec, June 15-18, 1955; 33. abstracted, A. M. A. Am. J. Dis. Child. 90:577, 1955. 34. Good, R. A.: Agammaglobulinemia, a Provocative Experiment of Nature , Staff Bull. Univ. Minnesota Hosp. 26:1, 1954. 35. Bush, J. A.: The Role of Trace Elements in Hemopoiesis and in the Therapy of Anemia , Pediatrics 17:586, 1956. 36. Scoular, F. I.: A Quantitative Study, by Spectrographic Analysis of Copper in Nutrition , J. Nutrition 16:437, 1938. 37. Macy, I. G.: Feeding School Children to Meet Dietary Needs , J. Am. Dietet. A. 20:602, 1944. 38. Cartwright, G. E.; Gubler, C. J.; Bush, J. A., and Wintrobe, M. M.: Studies on Copper Metabolism: XVII. Further Observations on the Anemia of Copper Deficiency in Swine , Blood 11:143, 1956. 39. Cartwright, G. E.: Dietary Factors Concerned in Erythropoiesis , Blood 2:111, 256, 1947. 40. Altmann, A., and Murray, J. F.: The Anaemia of Malignant Malnutrition (Infantile Pellagra, Kwashiorkor): Protein Deficiency as Possible Aetiological Factor , South African J. M. Sc. 13:91, 1948. 41. Brown, J. W.: The Effect of Protein Deficiency on Bone Marrow and Peripheral Blood of Young Albino Rats , Univ. Kansas Sc. Bull 36:55, 1954. 42. Zuelzer, W. W.: Twenty-Sixth Meeting of Pediatric Research Society, Buck Hill Falls, Pa., May, 1956.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Sep 1, 1956
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