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Total Body Water and Exchangeable Sodium in Normal Full-Term Newborn Infants

Total Body Water and Exchangeable Sodium in Normal Full-Term Newborn Infants Abstract During the past several years many clinical investigators focused their attentions on the measurement of bodily functions and compartments. Several methods for the measurement of the body's fluid compartments and electrolyte content have been developed and evaluated. These have been greatly facilitated by the application of isotopic tracer techniques. Values for the volumes of body compartments and their electrolyte contents have been established and the influence of various diseases on these moieties have been documented. Data on the total body water and electrolyte content of the newborn infant, however, have been somewhat limited. This study was undertaken to measure the total body water and exchangeable sodium in newborn infants. The current report presents the data obtained by measuring the total body water and exchangeable sodium simultaneously in a series of normal newborn infants. Subjects and Methods Studies were made on 17 newborn infants ranging in age from 6 hours to References 1. Talso, P. J.; Spafford, N. R.; Ferenzi, G., and Jackson, H. O.: Paradoxical Hyponatremia Associated with Congestive Heart Failure and with Cirrhosis of the Liver , Metabolism 5:58-69, 1956. 2. Talso, P. J.; Lahr, T. N.; Spafford, N.; Ferenzi, G., and Jackson, H. R. O.: A Comparison of the Volume of Distribution of Antipyrine, N-Acetyl-4-Amino-Antipyrine, and I131 Labeled 4-Iodo-Antipyrine in Human Beings , J. Lab. & Clin. Med. 46:619-623, 1955. 3. Corsa, L., Jr.; Gribetz, D.; Cook, C., and Talbot, N.: Total Body Exchangeable Water, Sodium and Potassium in "Hospital Normal" Infants and Children , Pediatrics 17:184-191, 1956. 4. Smith, C. A.: The Physiology of the Newborn Infant , Springfield, Ill., Charles C Thomas, Publisher, 1951. 5. Talso, P. J., and Spafford, N.: A Method for the Simultaneous Determination of Two Gamma Emitting Isotopes Applicable to Biological Samples, to be published. 6. Soberman, R.; Brodie, B. B.; Levy, B. B.; Axelrod, J.; Hollander, V., and Steele, J. M.: The Use of Antipyrine in the Measurement of Total Body Water in Man , J. Biol. Chem. 179:31-42, 1949. 7. Camerer, W., and Söldner: Die Chemische Zusammensetzung des Neugeborenen , Ztschr. Biol. 39:173, 1900. 8. Camerer, W., Jr.; Söldner, and Herzog: Die chemische Zusammensetzung des neugeborenen Menschen , Ztschr. Biol. 43:1, 1902. 9. Widdowson, E. M.; McCance, R. A., and Spray, C. M.: The Chemical Composition of the Human Body , Clin. Sc. 10:113-125, 1951. 10. Friis-Hansen, B.; Holiday, M.; Stapleton, T., and Wallace, W. M.: Total Body Water in Children , Pediatrics 7:321-327, 1951. 11. Bischoff, E.: Einige Gewichts und Trocken-Bestimmungen der Organe des menschlichen Körpers , Zschr. rat. Med. 20:75, 1863. 12. Shohl, A. T.: Mineral Metabolism , New York, Reinhold Publishing Corporation, 1939, p. 15. 13. Iob, V., and Swanson, W. W.: Mineral Growth of Human Fetus , Am. J. Dis. Child. 47:302-306, 1934. 14. Flexner, L. B.; Wilde, W. S.; Proctor, N. K.; Cowie, D. B.; Vosburgh, G. J., and Hellman, L. M.: The Estimation of Extracellular and Total Body Water in the Newborn Human Infant with Radioactive Sodium and Deuterium Oxide , J. Pediat. 30:413-415, 1947. 15. Perley, A. M.; Forbes, G. B., and Pennoyer, M. M.: Determination of Sodium24 "Space" in Infants, Children, and Adults , J. Pediat. 38:299-305, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Total Body Water and Exchangeable Sodium in Normal Full-Term Newborn Infants

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060030319001
Publisher site
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Abstract

Abstract During the past several years many clinical investigators focused their attentions on the measurement of bodily functions and compartments. Several methods for the measurement of the body's fluid compartments and electrolyte content have been developed and evaluated. These have been greatly facilitated by the application of isotopic tracer techniques. Values for the volumes of body compartments and their electrolyte contents have been established and the influence of various diseases on these moieties have been documented. Data on the total body water and electrolyte content of the newborn infant, however, have been somewhat limited. This study was undertaken to measure the total body water and exchangeable sodium in newborn infants. The current report presents the data obtained by measuring the total body water and exchangeable sodium simultaneously in a series of normal newborn infants. Subjects and Methods Studies were made on 17 newborn infants ranging in age from 6 hours to References 1. Talso, P. J.; Spafford, N. R.; Ferenzi, G., and Jackson, H. O.: Paradoxical Hyponatremia Associated with Congestive Heart Failure and with Cirrhosis of the Liver , Metabolism 5:58-69, 1956. 2. Talso, P. J.; Lahr, T. N.; Spafford, N.; Ferenzi, G., and Jackson, H. R. O.: A Comparison of the Volume of Distribution of Antipyrine, N-Acetyl-4-Amino-Antipyrine, and I131 Labeled 4-Iodo-Antipyrine in Human Beings , J. Lab. & Clin. Med. 46:619-623, 1955. 3. Corsa, L., Jr.; Gribetz, D.; Cook, C., and Talbot, N.: Total Body Exchangeable Water, Sodium and Potassium in "Hospital Normal" Infants and Children , Pediatrics 17:184-191, 1956. 4. Smith, C. A.: The Physiology of the Newborn Infant , Springfield, Ill., Charles C Thomas, Publisher, 1951. 5. Talso, P. J., and Spafford, N.: A Method for the Simultaneous Determination of Two Gamma Emitting Isotopes Applicable to Biological Samples, to be published. 6. Soberman, R.; Brodie, B. B.; Levy, B. B.; Axelrod, J.; Hollander, V., and Steele, J. M.: The Use of Antipyrine in the Measurement of Total Body Water in Man , J. Biol. Chem. 179:31-42, 1949. 7. Camerer, W., and Söldner: Die Chemische Zusammensetzung des Neugeborenen , Ztschr. Biol. 39:173, 1900. 8. Camerer, W., Jr.; Söldner, and Herzog: Die chemische Zusammensetzung des neugeborenen Menschen , Ztschr. Biol. 43:1, 1902. 9. Widdowson, E. M.; McCance, R. A., and Spray, C. M.: The Chemical Composition of the Human Body , Clin. Sc. 10:113-125, 1951. 10. Friis-Hansen, B.; Holiday, M.; Stapleton, T., and Wallace, W. M.: Total Body Water in Children , Pediatrics 7:321-327, 1951. 11. Bischoff, E.: Einige Gewichts und Trocken-Bestimmungen der Organe des menschlichen Körpers , Zschr. rat. Med. 20:75, 1863. 12. Shohl, A. T.: Mineral Metabolism , New York, Reinhold Publishing Corporation, 1939, p. 15. 13. Iob, V., and Swanson, W. W.: Mineral Growth of Human Fetus , Am. J. Dis. Child. 47:302-306, 1934. 14. Flexner, L. B.; Wilde, W. S.; Proctor, N. K.; Cowie, D. B.; Vosburgh, G. J., and Hellman, L. M.: The Estimation of Extracellular and Total Body Water in the Newborn Human Infant with Radioactive Sodium and Deuterium Oxide , J. Pediat. 30:413-415, 1947. 15. Perley, A. M.; Forbes, G. B., and Pennoyer, M. M.: Determination of Sodium24 "Space" in Infants, Children, and Adults , J. Pediat. 38:299-305, 1951.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Oct 1, 1956

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