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The Urinary Excretion of 17-Hydroxycorticosteroids by Premature Infants: Comparisons Between Premature Infants Experiencing Uneventful Courses and Those Having Clinical Difficulty, Including Death

The Urinary Excretion of 17-Hydroxycorticosteroids by Premature Infants: Comparisons Between... Abstract Many premature infants die without an apparent clinical cause, often unexpectedly. Other premature infants who experience clinical difficulties demonstrate sufficient signs to alert the experienced clinician. Since, in premature infants, the normal values have not been established for many of the parameters that would be useful in judging the severity and extent of disease or dysfunction, it is often difficult or impossible to minister accurately to the needs of the patient. The adrenal cortex is an organ of complex biochemical activity whose normal function is essential to the health of human beings. It has been suggested that newborn premature infants normally produce a minimal amount of 17-hydroxycorticosteroids (17-OHCS).1 At birth the mean values for urinary 17-OHCS were extremely low compared to those of normal adults, and they increased progressively during the first 40 days of life. Thus, there is evidence that in the newborn premature infant, adrenocortical function may References 1. Cranny, R. L., and Cranny, C. L.: The Excretion of Porter-Silber Chromogens by Premature Infants , A.M.A.J. Dis. Child. 95:401, 1958. 2. Reddy, W. J.: Modification of the Reddy-Jenkins-Thorn Method for the Estimation of 17-Hydroxycorticosteroids in Urine , Metabolism 3: 489, 1954. 3. Benirschke, K.; Bloch, E., and Hertig, A. T.: Concerning the Function of the Fetal Zone of the Human Adrenal Gland , Endocrinology 58:598, 1956.Crossref 4. Migeon, C. J.; Bertrand, J.; Wall, P. E.; Stempfel, R. S., and Prystowsky, H.: Metabolism and Placental Transmission of Cortisol During Pregnancy Near Term , Ciba Foundation Colloquia on Endocrinology, edited by G. E. W. Wolstenholme, New York, The Blakiston Company (division of McGraw-Hill Book Co., Inc.), 1957, Vol. 11, p. 338. 5. Colle, E., and Ulstrom, R. A.: Urinary Excretion of Corticosteroids in Infants: The Response to Surgery and Corticotrophin (ACTH) , A.M.A.J. Dis. Child. 98:574, 1959. 6. Cranny, R. L.; Kirschvink, J. F., and Kelley, V. C.: The Half-Life of Hydrocortisone in Normal Newborn Infants, A.M.A.J. Dis. Child, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A M A Journal of Diseases of Children American Medical Association

The Urinary Excretion of 17-Hydroxycorticosteroids by Premature Infants: Comparisons Between Premature Infants Experiencing Uneventful Courses and Those Having Clinical Difficulty, Including Death

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030346011
Publisher site
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Abstract

Abstract Many premature infants die without an apparent clinical cause, often unexpectedly. Other premature infants who experience clinical difficulties demonstrate sufficient signs to alert the experienced clinician. Since, in premature infants, the normal values have not been established for many of the parameters that would be useful in judging the severity and extent of disease or dysfunction, it is often difficult or impossible to minister accurately to the needs of the patient. The adrenal cortex is an organ of complex biochemical activity whose normal function is essential to the health of human beings. It has been suggested that newborn premature infants normally produce a minimal amount of 17-hydroxycorticosteroids (17-OHCS).1 At birth the mean values for urinary 17-OHCS were extremely low compared to those of normal adults, and they increased progressively during the first 40 days of life. Thus, there is evidence that in the newborn premature infant, adrenocortical function may References 1. Cranny, R. L., and Cranny, C. L.: The Excretion of Porter-Silber Chromogens by Premature Infants , A.M.A.J. Dis. Child. 95:401, 1958. 2. Reddy, W. J.: Modification of the Reddy-Jenkins-Thorn Method for the Estimation of 17-Hydroxycorticosteroids in Urine , Metabolism 3: 489, 1954. 3. Benirschke, K.; Bloch, E., and Hertig, A. T.: Concerning the Function of the Fetal Zone of the Human Adrenal Gland , Endocrinology 58:598, 1956.Crossref 4. Migeon, C. J.; Bertrand, J.; Wall, P. E.; Stempfel, R. S., and Prystowsky, H.: Metabolism and Placental Transmission of Cortisol During Pregnancy Near Term , Ciba Foundation Colloquia on Endocrinology, edited by G. E. W. Wolstenholme, New York, The Blakiston Company (division of McGraw-Hill Book Co., Inc.), 1957, Vol. 11, p. 338. 5. Colle, E., and Ulstrom, R. A.: Urinary Excretion of Corticosteroids in Infants: The Response to Surgery and Corticotrophin (ACTH) , A.M.A.J. Dis. Child. 98:574, 1959. 6. Cranny, R. L.; Kirschvink, J. F., and Kelley, V. C.: The Half-Life of Hydrocortisone in Normal Newborn Infants, A.M.A.J. Dis. Child, to be published.

Journal

A M A Journal of Diseases of Children – American Medical Association

Published: Mar 1, 1960

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