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The Treatment of Tinea Capitis with Orally Administered Griseofulvin

The Treatment of Tinea Capitis with Orally Administered Griseofulvin Abstract The changing epidemiological pattern of tinea capitis during the past two decades has emphasized the urgent need for an effective, simple, and relatively safe fungicidal agent. In this country, prior to 1940, approximately 80% of cases of tinea capitis were due to either Microsporum canis or Microsporum audouini. The number of cases of tinea capitis were comparatively small, and the incidence of disease due to these two organisms was approximately equal with local variations.1-4 During 1941 and 1942, in New York, there was observed a gradual increase in the number of cases of tinea capitis due to M. audouini. This gradual increase was followed, in 1943, by a sharp rise in the incidence of tinea capitis produced predominantly by this organism.1,4-6 In the ensuing five or six years the incidence of the disease produced by M. audouini increased to epidemic proportions and spread from New York to Albany, References 1. Montgomery, A. M.; Heinlein, J. A., and Karplick, F. E.: Ringworm of the Scalp in New York , New York J. Med. 48:629-630, 1948. 2. Carrick, L.: The Epidemiology of Tinea Capitis in Detroit School Children , J. Michigan M. Soc. 45:347-352, 1946. 3. Lewis, G. M.; Silvers, S. H.; Cipollaro, A. C.; Muskatblit, E., and Mitchell, H. H.: Measures to Prevent and Control Epidemics of Ringworm of Scalp , New York J. Med. 44:1327-1333, 1944. 4. Steves, R. J., and Lynch, E. W.: Ringworm of the Scalp , J.A.M.A. 133:304-309, 1947.Crossref 5. Lewis, G. M.; Hopper, M. E., and Reiss, F.: Ringworm of Scalp: Clinical Data on Recent Cases; Experiences with Local Endocrine Therapy , J.A.M.A. 132:62-65, 1946.Crossref 6. Schwartz, L.; Peck, S. M.; Botvinick, I.; Leibovitz, L., and Frasier, E. S.: Control of Ringworm of Scalp Among School Children in Hagerstown, Maryland 1944-1945 , J.A.M.A. 132:58-62, 1946.Crossref 7. Mitchell, J. H.: Epidemic Ringworm of the Scalp , M. Clin. North America 32:283-296, 1948. 8. Cooper, W. A., and Malone, J.: The Occurrence and Control of Ringworm of the Scalp in the United States , New York J. Med. 54:1645-1651, 1954. 9. Georg, L. K.: T. Tonsurans Ringworm: A New Public Health Problem , Pub. Health Rep. 67:53-54, 1952.Crossref 10. Howell, J. B.; Wilson, J. W., and Caro, M. R.: Tinea Capitis Caused by T. Tonsurans (Sulfureum or Crateriforme) , A.M.A. Arch. Dermat. & Syph. 75:194-205, 1952. 11. Price, H., and Taylor, D. R.: Trichophyton Tonsurans (Crateriforme) Infection of the Scalp , California Med. 76:283-288, 1952. 12. Joseph, H. L., and Halde, C.: Tinea Capitis Due to T. Tonsurans: Incidence, Diagnosis and Epidemiology in the San Francisco Bay Region , California Med. 83:371-375, 1955. 13. Munch, J. C.: Human Thallotoxicosis , J.A.M.A. 102:1929-1934, 1934. 14. McKee, G. M.; Muscheller, A., and Cipollaro, A. C.: Treatment of Tinea Capitis with Roentgen Rays , A.M.A. Arch. Dermat. & Syph. 53:458-470, 1946. 15. Combes, F. C., and Behrman, H. T.: Technique and Problems of Roentgen Ray Epilation , A.M.A. Arch. Dermat. & Syph. 57:74-89, 1948. 16. Oxford, A. E.; Raistrick, H., and Simonart, P.: Studies in the Biochemistry of Microorganisms: LX. Griseofulvin C17H17O6Cl, a Metabolic Product of Penicillium Griseo-Fulvum Direckx , Biochem. J. 33:240-248, 1939. 17. Grove, J. F.; Ismay, D.; MacMillan, J.; Mulholland, T. P. C., and Rogers, T.: The Structure of Griseofulvin , Chem. & Indust. 11:219, 1951. 18. Grove, J. F.; MacMillan, J.; Mulholland, T. P. C., and Rogers, T.: Griseofulvin: IV. Structure , J. Chem. Soc. 3977 -3987, 1952. 19. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature , London 182:1320-1321, 1958. 20. Brian, P. W.: Studies on the Biological Activity of Griseofulvin , Ann. Botany 13:59-77, 1949. 21. Brian, P. W.; Hemming, H. G., and McGowan, J. D.: Origin of a Toxicity to Mycorrhiza in Wareham Heath Soil , Nature , London 155: 637, 1945. 22. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewskii Zal. I, Biological Assay, Production and Isolation of "Curling-Factor," Tr. Brit. Mycol. Soc. 29:173-187, 1946.Crossref 23. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling Factor," Nature , London 160:574, 1947.Crossref 24. Fungicide by Mouth (Leading Articles) , Lancet 2:1216, 1958. 25. Blank, H., and Roth, F. J.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259-266, 1959.Crossref 26. Williams, D. I.; Marten, R. H., and Sarkany, I.: Oral Treatment of Ringworm with Griseofulvin , Lancet 2:1212-1213, 1958.Crossref 27. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature , London 182:476-477, 1958.Crossref 28. Martin, A. R.: The Systemic and Local Treatment of Experimental Dermatophytosis with Griseofulvin , J. Invest. Dermat. 32:525-528, 1959.Crossref 29. Lauder, I. M., and O'Sullivan, J. G.: Ringworm in Cattle: Prevention and Treatment with Griseofulvin , Vet. Rec. 70:949-951, 1958. 30. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Presence of Griseofulvin in Hair of Guinea Pigs After Oral Administration , Nature , London 183:256-257, 1959.Crossref 31. Livingood, C. S., and Pillsbury, D. M.: Ringworm of the Scalp: Prolonged Observation, Family Investigation, Cultural and Immunologic Studies in 125 Cases , J. Invest. Dermat. 4:43-57, 1941.Crossref 32. Laur, W. E.: Spontaneous Cure of Tinea Capitis Due to M. Audouini , A.M.A. Arch. Dermat. & Syph. 64:364-366, 1951. 33. Kligman, A. N.: Pathogenesis of Tinea Capitis Due to M. Audouini and M. Canis: I. Gross Observations Following the Inoculation of Humans , J. Invest. Dermat. 18:231-245, 1952. 34. Lewis, G. M., and Miller, H. C.: Ringworm of the Scalp: A Report of Three Cases Due to M. Lanosum with a Tendency to Spontaneous Recovery , Arch. Dermat. & Syph. 29:890-892, 1934. 35. Lewis, G. M.: Ringworm of the Scalp: Curability of Infections Caused by "Animal" Microsporons , Am. J.M. Sc. 189:354-370 1935. 36. Lewis, G. M., and Hopper, M. D.: Ringworm of the Scalp: V. Mechanism of Cure of Infections Caused by M. Lanosum , Arch. Dermat. & Syph. 36:1194-1196, 1937. 37. Lewis, G. M., and Hopper, M. E.: Ringworm of the Scalp: III. Clinical and Experimental Studies in Types of Infections Resistant to Treatment , Arch. Dermat. & Syph. 35:460-470, 1937. 38. Sternberg, T. H.; Newcomer, V. D.; Reisner, R. M.; Homer, R. S., and Sorensen, L. J.: The Treatment of Superficial Fungus Infections in Man with Orally Administered Griseofulvin , Current Therap. Res. 1:1-16, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

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References (50)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030587004
Publisher site
See Article on Publisher Site

Abstract

Abstract The changing epidemiological pattern of tinea capitis during the past two decades has emphasized the urgent need for an effective, simple, and relatively safe fungicidal agent. In this country, prior to 1940, approximately 80% of cases of tinea capitis were due to either Microsporum canis or Microsporum audouini. The number of cases of tinea capitis were comparatively small, and the incidence of disease due to these two organisms was approximately equal with local variations.1-4 During 1941 and 1942, in New York, there was observed a gradual increase in the number of cases of tinea capitis due to M. audouini. This gradual increase was followed, in 1943, by a sharp rise in the incidence of tinea capitis produced predominantly by this organism.1,4-6 In the ensuing five or six years the incidence of the disease produced by M. audouini increased to epidemic proportions and spread from New York to Albany, References 1. Montgomery, A. M.; Heinlein, J. A., and Karplick, F. E.: Ringworm of the Scalp in New York , New York J. Med. 48:629-630, 1948. 2. Carrick, L.: The Epidemiology of Tinea Capitis in Detroit School Children , J. Michigan M. Soc. 45:347-352, 1946. 3. Lewis, G. M.; Silvers, S. H.; Cipollaro, A. C.; Muskatblit, E., and Mitchell, H. H.: Measures to Prevent and Control Epidemics of Ringworm of Scalp , New York J. Med. 44:1327-1333, 1944. 4. Steves, R. J., and Lynch, E. W.: Ringworm of the Scalp , J.A.M.A. 133:304-309, 1947.Crossref 5. Lewis, G. M.; Hopper, M. E., and Reiss, F.: Ringworm of Scalp: Clinical Data on Recent Cases; Experiences with Local Endocrine Therapy , J.A.M.A. 132:62-65, 1946.Crossref 6. Schwartz, L.; Peck, S. M.; Botvinick, I.; Leibovitz, L., and Frasier, E. S.: Control of Ringworm of Scalp Among School Children in Hagerstown, Maryland 1944-1945 , J.A.M.A. 132:58-62, 1946.Crossref 7. Mitchell, J. H.: Epidemic Ringworm of the Scalp , M. Clin. North America 32:283-296, 1948. 8. Cooper, W. A., and Malone, J.: The Occurrence and Control of Ringworm of the Scalp in the United States , New York J. Med. 54:1645-1651, 1954. 9. Georg, L. K.: T. Tonsurans Ringworm: A New Public Health Problem , Pub. Health Rep. 67:53-54, 1952.Crossref 10. Howell, J. B.; Wilson, J. W., and Caro, M. R.: Tinea Capitis Caused by T. Tonsurans (Sulfureum or Crateriforme) , A.M.A. Arch. Dermat. & Syph. 75:194-205, 1952. 11. Price, H., and Taylor, D. R.: Trichophyton Tonsurans (Crateriforme) Infection of the Scalp , California Med. 76:283-288, 1952. 12. Joseph, H. L., and Halde, C.: Tinea Capitis Due to T. Tonsurans: Incidence, Diagnosis and Epidemiology in the San Francisco Bay Region , California Med. 83:371-375, 1955. 13. Munch, J. C.: Human Thallotoxicosis , J.A.M.A. 102:1929-1934, 1934. 14. McKee, G. M.; Muscheller, A., and Cipollaro, A. C.: Treatment of Tinea Capitis with Roentgen Rays , A.M.A. Arch. Dermat. & Syph. 53:458-470, 1946. 15. Combes, F. C., and Behrman, H. T.: Technique and Problems of Roentgen Ray Epilation , A.M.A. Arch. Dermat. & Syph. 57:74-89, 1948. 16. Oxford, A. E.; Raistrick, H., and Simonart, P.: Studies in the Biochemistry of Microorganisms: LX. Griseofulvin C17H17O6Cl, a Metabolic Product of Penicillium Griseo-Fulvum Direckx , Biochem. J. 33:240-248, 1939. 17. Grove, J. F.; Ismay, D.; MacMillan, J.; Mulholland, T. P. C., and Rogers, T.: The Structure of Griseofulvin , Chem. & Indust. 11:219, 1951. 18. Grove, J. F.; MacMillan, J.; Mulholland, T. P. C., and Rogers, T.: Griseofulvin: IV. Structure , J. Chem. Soc. 3977 -3987, 1952. 19. Paget, G. E., and Walpole, A. L.: Some Cytological Effects of Griseofulvin , Nature , London 182:1320-1321, 1958. 20. Brian, P. W.: Studies on the Biological Activity of Griseofulvin , Ann. Botany 13:59-77, 1949. 21. Brian, P. W.; Hemming, H. G., and McGowan, J. D.: Origin of a Toxicity to Mycorrhiza in Wareham Heath Soil , Nature , London 155: 637, 1945. 22. Brian, P. W.; Curtis, P. J., and Hemming, H. G.: A Substance Causing Abnormal Development of Fungal Hyphae Produced by Penicillium Janczewskii Zal. I, Biological Assay, Production and Isolation of "Curling-Factor," Tr. Brit. Mycol. Soc. 29:173-187, 1946.Crossref 23. Grove, J. F., and McGowan, J. C.: Identity of Griseofulvin and "Curling Factor," Nature , London 160:574, 1947.Crossref 24. Fungicide by Mouth (Leading Articles) , Lancet 2:1216, 1958. 25. Blank, H., and Roth, F. J.: The Treatment of Dermatomycoses with Orally Administered Griseofulvin , A.M.A. Arch. Dermat. 79:259-266, 1959.Crossref 26. Williams, D. I.; Marten, R. H., and Sarkany, I.: Oral Treatment of Ringworm with Griseofulvin , Lancet 2:1212-1213, 1958.Crossref 27. Gentles, J. C.: Experimental Ringworm in Guinea Pigs: Oral Treatment with Griseofulvin , Nature , London 182:476-477, 1958.Crossref 28. Martin, A. R.: The Systemic and Local Treatment of Experimental Dermatophytosis with Griseofulvin , J. Invest. Dermat. 32:525-528, 1959.Crossref 29. Lauder, I. M., and O'Sullivan, J. G.: Ringworm in Cattle: Prevention and Treatment with Griseofulvin , Vet. Rec. 70:949-951, 1958. 30. Gentles, J. C.; Barnes, M. J., and Fantes, K. H.: Presence of Griseofulvin in Hair of Guinea Pigs After Oral Administration , Nature , London 183:256-257, 1959.Crossref 31. Livingood, C. S., and Pillsbury, D. M.: Ringworm of the Scalp: Prolonged Observation, Family Investigation, Cultural and Immunologic Studies in 125 Cases , J. Invest. Dermat. 4:43-57, 1941.Crossref 32. Laur, W. E.: Spontaneous Cure of Tinea Capitis Due to M. Audouini , A.M.A. Arch. Dermat. & Syph. 64:364-366, 1951. 33. Kligman, A. N.: Pathogenesis of Tinea Capitis Due to M. Audouini and M. Canis: I. Gross Observations Following the Inoculation of Humans , J. Invest. Dermat. 18:231-245, 1952. 34. Lewis, G. M., and Miller, H. C.: Ringworm of the Scalp: A Report of Three Cases Due to M. Lanosum with a Tendency to Spontaneous Recovery , Arch. Dermat. & Syph. 29:890-892, 1934. 35. Lewis, G. M.: Ringworm of the Scalp: Curability of Infections Caused by "Animal" Microsporons , Am. J.M. Sc. 189:354-370 1935. 36. Lewis, G. M., and Hopper, M. D.: Ringworm of the Scalp: V. Mechanism of Cure of Infections Caused by M. Lanosum , Arch. Dermat. & Syph. 36:1194-1196, 1937. 37. Lewis, G. M., and Hopper, M. E.: Ringworm of the Scalp: III. Clinical and Experimental Studies in Types of Infections Resistant to Treatment , Arch. Dermat. & Syph. 35:460-470, 1937. 38. Sternberg, T. H.; Newcomer, V. D.; Reisner, R. M.; Homer, R. S., and Sorensen, L. J.: The Treatment of Superficial Fungus Infections in Man with Orally Administered Griseofulvin , Current Therap. Res. 1:1-16, 1959.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1960

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