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The Half-Life of Hydrocortisone in Normal Newborn Infants

The Half-Life of Hydrocortisone in Normal Newborn Infants Abstract The exact functional status of the adrenal cortex during the newborn period and the limits within which this gland functions during early life are not yet known. Although data are available concerning the urinary excretion of steroids by individual normal premature and term infants,1,2 the correlation between the function of the adrenal cortex, blood levels of adrenal steroids, and tissue utilization and urinary excretion of these hormones remains obscure. It has been generally accepted that the biological half-life of administered hydrocortisone is an indicator of steroid metabolism and it has been shown that the half-life of hydrocortisone is altered in certain diseases, such as rheumatic fever, cirrhosis, and thyrotoxicosis.3,4 The purpose of this communication is to report the results of hydrocortisone half-life studies which were performed on normal newborn infants. Method and Materials Thirteen hydrocortisone half-life determinations were done on 12 patients; 3 patients were "normal" premature infants, References 1. Cranny, R. L., and Cranny, C. L.: The Urinary Excretion of Porter-Silber Chromogens by Premature Infants , A.M.A.J. Dis. Child. 95: 401, 1958. 2. Ulstrom, R. A., and Doeden, D.: Chromatographic Studies of Urinary Steroids in Term and Premature Infants , in Adrenal Function in Infants and Children—A Symposium , edited by L. I. Gardner, New York, Grune & Stratton, Inc., 1956, p. 31. 3. Done, A. K.; Ely, R. S.; Olsen, L. J., and Kelley, V. C.: The in Vivo Half-Life of Exogenous Hydrocortisone in Patients with Rheumatic Fever , Metabolism 4:416, 1955. 4. Peterson, R. E., and Wyngaarden, J. B.: Physiological Disposition and Metabolic Fate of Hydrocortisone in Man , Ann. New York Acad. Sc. 61:297, 1955.Crossref 5. Nelson, D. H., and Samuels, L. T.: A Method for the Determining of 17-Hydroxycorticosteroids in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519, 1952.Crossref 6. Madsen, J. M.; Done, A. K.; Ely, R. S., and Kelley, V. C.: Evaluation of Water-Soluble Hemisuccinate Esters of Hydrocortisone and Prednisolone: Plasma 17-Hydroxycorticosteroid Concentrations Following Intravenous Administration , A.M.A.J. Dis. Child. 97:66, 1959.Crossref 7. Bongiovanni, A. M.; Eberlein, W. R.; Westphal, M., and Boggs, T.: Prolonged Turnover Rate of Hydrocortisone in the Newborn Infant , J. Clin. Endocrinol. 18:1127, 1958.Crossref 8. Samuels, L. T.; Brown, H.; Eik-Nes, K.; Tyler, F. H., and Dominguez, O.: Extra-Adrenal Factors Affecting the Levels of 17-Hydroxycorticosteroids in Plasma , in Ciba Foundation Colloquia, Hormones in Blood , Boston, Little, Brown & Company, 1957, p. 211. 9. Collins, E. J.; Forist, A. A., and Nadolski, E. B.: Δ1-Hydrocortisone and Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations in the Dog Following Oral and Intravenous Administration , Proc. Soc. Exper. Biol. & Med. 93:369, 1956. 10. Kretchmer, N.: Enzymatic Patterns During Development , Pediatrics 23:606, 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

The Half-Life of Hydrocortisone in Normal Newborn Infants

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030439006
Publisher site
See Article on Publisher Site

Abstract

Abstract The exact functional status of the adrenal cortex during the newborn period and the limits within which this gland functions during early life are not yet known. Although data are available concerning the urinary excretion of steroids by individual normal premature and term infants,1,2 the correlation between the function of the adrenal cortex, blood levels of adrenal steroids, and tissue utilization and urinary excretion of these hormones remains obscure. It has been generally accepted that the biological half-life of administered hydrocortisone is an indicator of steroid metabolism and it has been shown that the half-life of hydrocortisone is altered in certain diseases, such as rheumatic fever, cirrhosis, and thyrotoxicosis.3,4 The purpose of this communication is to report the results of hydrocortisone half-life studies which were performed on normal newborn infants. Method and Materials Thirteen hydrocortisone half-life determinations were done on 12 patients; 3 patients were "normal" premature infants, References 1. Cranny, R. L., and Cranny, C. L.: The Urinary Excretion of Porter-Silber Chromogens by Premature Infants , A.M.A.J. Dis. Child. 95: 401, 1958. 2. Ulstrom, R. A., and Doeden, D.: Chromatographic Studies of Urinary Steroids in Term and Premature Infants , in Adrenal Function in Infants and Children—A Symposium , edited by L. I. Gardner, New York, Grune & Stratton, Inc., 1956, p. 31. 3. Done, A. K.; Ely, R. S.; Olsen, L. J., and Kelley, V. C.: The in Vivo Half-Life of Exogenous Hydrocortisone in Patients with Rheumatic Fever , Metabolism 4:416, 1955. 4. Peterson, R. E., and Wyngaarden, J. B.: Physiological Disposition and Metabolic Fate of Hydrocortisone in Man , Ann. New York Acad. Sc. 61:297, 1955.Crossref 5. Nelson, D. H., and Samuels, L. T.: A Method for the Determining of 17-Hydroxycorticosteroids in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519, 1952.Crossref 6. Madsen, J. M.; Done, A. K.; Ely, R. S., and Kelley, V. C.: Evaluation of Water-Soluble Hemisuccinate Esters of Hydrocortisone and Prednisolone: Plasma 17-Hydroxycorticosteroid Concentrations Following Intravenous Administration , A.M.A.J. Dis. Child. 97:66, 1959.Crossref 7. Bongiovanni, A. M.; Eberlein, W. R.; Westphal, M., and Boggs, T.: Prolonged Turnover Rate of Hydrocortisone in the Newborn Infant , J. Clin. Endocrinol. 18:1127, 1958.Crossref 8. Samuels, L. T.; Brown, H.; Eik-Nes, K.; Tyler, F. H., and Dominguez, O.: Extra-Adrenal Factors Affecting the Levels of 17-Hydroxycorticosteroids in Plasma , in Ciba Foundation Colloquia, Hormones in Blood , Boston, Little, Brown & Company, 1957, p. 211. 9. Collins, E. J.; Forist, A. A., and Nadolski, E. B.: Δ1-Hydrocortisone and Hydrocortisone: Plasma 17-Hydroxycorticosteroid Concentrations in the Dog Following Oral and Intravenous Administration , Proc. Soc. Exper. Biol. & Med. 93:369, 1956. 10. Kretchmer, N.: Enzymatic Patterns During Development , Pediatrics 23:606, 1959.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1960

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