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Studies on Acute Iron Poisoning

Studies on Acute Iron Poisoning Abstract The widespread use of hematinics has increased the hazard of iron poisoning of infants and children. The symptoms are similar in humans and in some animal species, thus making it possible to duplicate the events of accidental poisoning in the laboratory and to evaluate antidotal procedures. Materials and Methods Twelve mongrel dogs in good health were used. The animals were maintained on a standard diet but were fasted for 24 hours before experimentation. To avoid vomiting and to simulate the delay in treatment that might be expected in poisoned children, solutions of ferrous sulfate were introduced directly into the jejunum of the dogs by syringe and needle after a midline exposure of the abdominal cavity. In this way the dose of iron was known with certainty.The experiments were performed under light pentobarbital anesthesia (30 mg/kg. intravenously). In some instances small supplementary doses were necessary. In each dog an endotracheal References 1. Burch, H.; Lowry, O.; Bessey, O., and Berson, B.: The Determination of Iron in Small Volumes of Blood and Serum , J. Biol. Chem. 174: 791, 1948. 2. Rath, C. E., and Finch, C. A.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXVIII. Serum Iron Transport; Measurement of Iron-Binding Capacity of Serum in Man , J. Clin. Invest. 28:79, 1949.Crossref 3. Aldrich, R. A.: Acute Iron Toxicity , in Iron in Clinical Medicine , edited by R. O. Wallerstein and S. R. Mettier, Berkeley, Calif., University of California Press, 1958, pp. 93-95. 4. Reissmann, K.; Coleman, T., Budai, B., and Moriarity, L.: Acute Intestinal Iron Intoxication: I. Iron Absorption, Serum Iron, and Autopsy Findings , Blood 10:35, 1955. 5. Mazur, A., and Schorr, E.: Hepatorenal Factors in Circulatory Homeostasis: IX. The Identification of the Hepatic Vasodepressor Sub stance V.D.M. with ferritin , J. Biol. Chem. 176: 771, 1948. 6. Fine, J.: The Bacterial Factor in Experimental Shock , in Shock and Circulatory Homeostasis , in Transactions of the Fifth Conference, 1955, New York, Josiah Macy, Jr. Foundation Publications, 1957, pp. 37-101. 7. Reissmann, K., and Coleman, T.: Acute Intestinal Iron Intoxication: II. Metabolic, Respiratory, and Circulatory Effects of Absorbed Iron Salts , Blood 10:46, 1955. 8. Foreman, H.; Huff, R. L.; Oda, J. M., and Garcia, J.: Use of a Chelating Agent for Accelerating Excretion of Radioiron , Proc. Soc. Exper. Biol. & Med. 79:520, 1952. 9. McLaurin, R. L., and Nichols, J. B., Jr.: Extensive Cranial Decompression in Treatment of Severe Lead Encephalopathy , Pediatrics 20:653, 1957. 10. Spencer, I. O. B.: Ferrous Sulphate Poisoning with Gross Stricture of the Stomach , Brit. M.J. 2:1112, 1951. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Studies on Acute Iron Poisoning

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030020004
Publisher site
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Abstract

Abstract The widespread use of hematinics has increased the hazard of iron poisoning of infants and children. The symptoms are similar in humans and in some animal species, thus making it possible to duplicate the events of accidental poisoning in the laboratory and to evaluate antidotal procedures. Materials and Methods Twelve mongrel dogs in good health were used. The animals were maintained on a standard diet but were fasted for 24 hours before experimentation. To avoid vomiting and to simulate the delay in treatment that might be expected in poisoned children, solutions of ferrous sulfate were introduced directly into the jejunum of the dogs by syringe and needle after a midline exposure of the abdominal cavity. In this way the dose of iron was known with certainty.The experiments were performed under light pentobarbital anesthesia (30 mg/kg. intravenously). In some instances small supplementary doses were necessary. In each dog an endotracheal References 1. Burch, H.; Lowry, O.; Bessey, O., and Berson, B.: The Determination of Iron in Small Volumes of Blood and Serum , J. Biol. Chem. 174: 791, 1948. 2. Rath, C. E., and Finch, C. A.: Chemical, Clinical and Immunological Studies on the Products of Human Plasma Fractionation: XXXVIII. Serum Iron Transport; Measurement of Iron-Binding Capacity of Serum in Man , J. Clin. Invest. 28:79, 1949.Crossref 3. Aldrich, R. A.: Acute Iron Toxicity , in Iron in Clinical Medicine , edited by R. O. Wallerstein and S. R. Mettier, Berkeley, Calif., University of California Press, 1958, pp. 93-95. 4. Reissmann, K.; Coleman, T., Budai, B., and Moriarity, L.: Acute Intestinal Iron Intoxication: I. Iron Absorption, Serum Iron, and Autopsy Findings , Blood 10:35, 1955. 5. Mazur, A., and Schorr, E.: Hepatorenal Factors in Circulatory Homeostasis: IX. The Identification of the Hepatic Vasodepressor Sub stance V.D.M. with ferritin , J. Biol. Chem. 176: 771, 1948. 6. Fine, J.: The Bacterial Factor in Experimental Shock , in Shock and Circulatory Homeostasis , in Transactions of the Fifth Conference, 1955, New York, Josiah Macy, Jr. Foundation Publications, 1957, pp. 37-101. 7. Reissmann, K., and Coleman, T.: Acute Intestinal Iron Intoxication: II. Metabolic, Respiratory, and Circulatory Effects of Absorbed Iron Salts , Blood 10:46, 1955. 8. Foreman, H.; Huff, R. L.; Oda, J. M., and Garcia, J.: Use of a Chelating Agent for Accelerating Excretion of Radioiron , Proc. Soc. Exper. Biol. & Med. 79:520, 1952. 9. McLaurin, R. L., and Nichols, J. B., Jr.: Extensive Cranial Decompression in Treatment of Severe Lead Encephalopathy , Pediatrics 20:653, 1957. 10. Spencer, I. O. B.: Ferrous Sulphate Poisoning with Gross Stricture of the Stomach , Brit. M.J. 2:1112, 1951.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Jan 1, 1960

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