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Struma Lymphomatosa (Hashimoto's Disease): Report of a Case in Thirteen-Year-Old Boy

Struma Lymphomatosa (Hashimoto's Disease): Report of a Case in Thirteen-Year-Old Boy Abstract Struma lymphomatosa is characterized as a progressive disease of the thyroid gland of unknown etiology, occurring almost entirely in females. It appears predominantly in middle age. Although there is a divergence of opinion as to whether it is inflamatory in nature, it is generally classified as a form of thyroiditis. The thyroid gland is grossly enlarged, firm, rubbery, and may be lobulated with a scalloped border. The capsule of the gland is intact with no adhesions to underlying or adjacent structures. Both lobes of the gland are involved in almost all cases. Microscopically, there is marked lymphoid infiltration, atrophic follicles with scanty colloid present, and mild fibrosis. Frequently, there are large hyperplastic lymph nodules with germinal centers present. The patient commonly complains of fullness of the neck and dysphagia. The results of thyroid function tests are variable, and there seems to be no specific diagnostic pattern. Gribetz and co-workers12 References 1. Hashimoto, A.: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa) , Arch. klin. Chir. 97:219-248, 1912. 2. Graham, A.: Riedel's Struma in Contrast to Struma Lymphomatosa (Hashimoto) , West. J. Surg. 39:681-689, 1931. 3. McClintock, J. C., and Wright, A. W.: Riedel's Struma and Struma Lymphomatosa (Hashimoto): Comparative Study , Ann. Surg. 106:11-32, 1937.Crossref 4. Joll, C. A.: Pathology, Diagnosis, and Treatment of Hashimoto's Disease (Struma Lymphomatosa) , Brit. J. Surg. 27:351-389, 1939.Crossref 5. Statland, H.; Wasserman, M. M., and Vickery, A. L.: Struma Lymphomatosa (Hashimoto's Struma): Review of 51 Cases with Discussion of Endocrinologic Aspects , A. M. A. Arch. Int. Med. 88:659-678, 1951.Crossref 6. Lindsay, S.; Daily, M. E.; Friedlander, J.; Yee, G., and Soley, M. H.: Chronic Thyroiditis: Clinical and Pathological Study of 354 Patients , J. Clin. Endocrinol. 12:1578-1600, 1952.Crossref 7. Furr, W. E., and Crile, G., Jr.: Struma Lymphomatosa: Clinical Manifestations and Response to Therapy , Tr. Am. Goiter A. (1953) pp. 66-73, 1954. 8. Marshall, S. F., and Meissner, W. A.: Struma Lymphomatosa (Hashimoto's Disease) , Ann. Surg. 141:737-746, 1955.Crossref 9. Hazard, J. B.: Thyroiditis: A Review: Part II , Am. J. Clin. Path. 25:399-426, 1955. 10. Blake, K. W., and Sturgeon, C. T.: Struma Lymphomatosa , Surg, Gynec. & Obst. 97:312-317, 1953. 11. Means, J. H.: The Thyroid and Its Diseases , Philadelphia, J. B. Lippincott Company, 1948. 12. Gribetz, D.; Talbot, N. B., and Crawford, J. D.: Goiter Due to Lymphocytic Thyroiditis (Hashimoto's Struma): Its Occurrence in Preadolescent and Adolescent Girls , New England J. Med. 250:555-557, 1954. 13. Davis, H. C., and Hanske, E. A.: Hashimoto's Disease in Childhood , A. M. A. Am. J. Dis. Child. 90:173-175, 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Struma Lymphomatosa (Hashimoto's Disease): Report of a Case in Thirteen-Year-Old Boy

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060030586008
Publisher site
See Article on Publisher Site

Abstract

Abstract Struma lymphomatosa is characterized as a progressive disease of the thyroid gland of unknown etiology, occurring almost entirely in females. It appears predominantly in middle age. Although there is a divergence of opinion as to whether it is inflamatory in nature, it is generally classified as a form of thyroiditis. The thyroid gland is grossly enlarged, firm, rubbery, and may be lobulated with a scalloped border. The capsule of the gland is intact with no adhesions to underlying or adjacent structures. Both lobes of the gland are involved in almost all cases. Microscopically, there is marked lymphoid infiltration, atrophic follicles with scanty colloid present, and mild fibrosis. Frequently, there are large hyperplastic lymph nodules with germinal centers present. The patient commonly complains of fullness of the neck and dysphagia. The results of thyroid function tests are variable, and there seems to be no specific diagnostic pattern. Gribetz and co-workers12 References 1. Hashimoto, A.: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa) , Arch. klin. Chir. 97:219-248, 1912. 2. Graham, A.: Riedel's Struma in Contrast to Struma Lymphomatosa (Hashimoto) , West. J. Surg. 39:681-689, 1931. 3. McClintock, J. C., and Wright, A. W.: Riedel's Struma and Struma Lymphomatosa (Hashimoto): Comparative Study , Ann. Surg. 106:11-32, 1937.Crossref 4. Joll, C. A.: Pathology, Diagnosis, and Treatment of Hashimoto's Disease (Struma Lymphomatosa) , Brit. J. Surg. 27:351-389, 1939.Crossref 5. Statland, H.; Wasserman, M. M., and Vickery, A. L.: Struma Lymphomatosa (Hashimoto's Struma): Review of 51 Cases with Discussion of Endocrinologic Aspects , A. M. A. Arch. Int. Med. 88:659-678, 1951.Crossref 6. Lindsay, S.; Daily, M. E.; Friedlander, J.; Yee, G., and Soley, M. H.: Chronic Thyroiditis: Clinical and Pathological Study of 354 Patients , J. Clin. Endocrinol. 12:1578-1600, 1952.Crossref 7. Furr, W. E., and Crile, G., Jr.: Struma Lymphomatosa: Clinical Manifestations and Response to Therapy , Tr. Am. Goiter A. (1953) pp. 66-73, 1954. 8. Marshall, S. F., and Meissner, W. A.: Struma Lymphomatosa (Hashimoto's Disease) , Ann. Surg. 141:737-746, 1955.Crossref 9. Hazard, J. B.: Thyroiditis: A Review: Part II , Am. J. Clin. Path. 25:399-426, 1955. 10. Blake, K. W., and Sturgeon, C. T.: Struma Lymphomatosa , Surg, Gynec. & Obst. 97:312-317, 1953. 11. Means, J. H.: The Thyroid and Its Diseases , Philadelphia, J. B. Lippincott Company, 1948. 12. Gribetz, D.; Talbot, N. B., and Crawford, J. D.: Goiter Due to Lymphocytic Thyroiditis (Hashimoto's Struma): Its Occurrence in Preadolescent and Adolescent Girls , New England J. Med. 250:555-557, 1954. 13. Davis, H. C., and Hanske, E. A.: Hashimoto's Disease in Childhood , A. M. A. Am. J. Dis. Child. 90:173-175, 1955.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1956

References