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Serial Enzyme Studies of Serum and Cerebrospinal Fluid in Amaurotic Family Idiocy

Serial Enzyme Studies of Serum and Cerebrospinal Fluid in Amaurotic Family Idiocy Abstract The diagnostic utility of enzyme level analysis in biologic fluids has only recently been explored on a broad basis.1,2,3 Particular emphasis has been placed upon the circulating glycolytic and transaminating enzymes. Based upon the supposition that for each determinable enzyme, there exists a specified pattern of concentration within individual tissues, it has been suggested and experimentally demonstrated that a rise in the serum content of any particular enzyme is a reflection of necrobiosis in such organs characterized by high concentration of that enzyme. It is further presumed that the enzyme elevation in serum represents a liberation from affected tissues rather than an elaboration. This is strengthened by the observation that the rise in circulating enzyme parallels the period of active destruction of the specified tissue and that such enzyme tests are of no avail as a measure of previous or quiescent degeneration. This concept, exemplified by the term "chemical References 1. Karmen, A.; Wróblewski, F., and La Due, J.: Transaminase Activity in Human Blood , J. Clin. Invest. , 34:126-133, 1955.Crossref 2. Schapira, G.; Dreyfus, J. C.; Schapira, F., and Kruh, J.: Glycogenolytic Enzymes in Human Progressive Muscular Dystrophy , Am. J. Phys. Med. , 35:313-319, 1955. 3. Wróblewski, F., and La Due, J.: Lactic Dehydrogenase Activity in Blood , Proc. Soc. Exp. Biol. & Med. , 90:210-213, 1955. 4. Aronson, S. M., and Volk, B. W.: Studies on Serum Aldolase Activity in Neuromuscular Disorders, I. Clinical Applications , Am. J. Med. , 22:414-421, 1957. 5. Volk, B. W.; Losner, S.; Aronson, S. M., and Lew, H.: The Serum Aldolase Level in Acute Myocardial Infarction , Am. J. Med. Sci. , 232:38-43. 1956. 6. Aronson, S. M.; Saifer, A.; Kanof, A., and Volk, B. W.: Progression of Amaurotic Family Idiocy as Reflected by Serum and Cerebrospinal Fluid Changes , Am. J. Med. , 24:390-401, 1958. 7. Aronson, S. M.; Volk, B. W., and Epstein, N.: Morphologic Evolution of Amaurotic Family Idiocy. The Protracted Phase of the Disease , Am. J. Path. , 31:609-631, 1955. 8. Sibley, J. A., and Lehninger, A. L.: Determination of Aldolase in Animal Tissues , J. Biol. Chem. , 177:859-872, 1949. 9. Bodansky, O.: Phosphohexose Isomerase in Cancer. I. Method of Determination and Establishment of Range of Normal Values , Cancer 7:1191-1199, 1954. 10. Hinsberg, K.: Der Diagnostische Wert DPN-abhängiger Enzyme , Scand. J. Clin. and Lab. Invest. 10 ( (Supplement 31) ):201-229, 1957. 11. Aronson, S. M., and Volk, B. W.: Serum Aldolase Activity in Neuromuscular Disorders, 2. Experimental Application , Proc. Soc. Exp. Biol. & Med., 94:360-363, 1957. 12. Wakim, K. G., and Fleisher, G. A.: The Effect of Experimental Cerebral Infarction on Transaminase Activity in Serum, Cerebrospinal Fluid, and Infarcted Tissue , Proc. Staff Meet., Mayo Clin. , 31:391-399, 1956. 13. Aronson, S. M.; Saifer, A.; Perle, G., and Volk, B. W.: Cerebrospinal Fluid Enzymes in Central Nervous System Lipidoses , Proc. Soc. Exp. Biol. & Med. , 97:331-334, 1958. 14. Wróblewski, F.; Decker, B., and Wróblewski, R.: Activity of Lactic Dehydrogenase in Spinal Fluid , Am. J. Clin. Path. , 28:269-271, 1957. 15. Sobotka, H.: This symposium. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Serial Enzyme Studies of Serum and Cerebrospinal Fluid in Amaurotic Family Idiocy

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070010686006
Publisher site
See Article on Publisher Site

Abstract

Abstract The diagnostic utility of enzyme level analysis in biologic fluids has only recently been explored on a broad basis.1,2,3 Particular emphasis has been placed upon the circulating glycolytic and transaminating enzymes. Based upon the supposition that for each determinable enzyme, there exists a specified pattern of concentration within individual tissues, it has been suggested and experimentally demonstrated that a rise in the serum content of any particular enzyme is a reflection of necrobiosis in such organs characterized by high concentration of that enzyme. It is further presumed that the enzyme elevation in serum represents a liberation from affected tissues rather than an elaboration. This is strengthened by the observation that the rise in circulating enzyme parallels the period of active destruction of the specified tissue and that such enzyme tests are of no avail as a measure of previous or quiescent degeneration. This concept, exemplified by the term "chemical References 1. Karmen, A.; Wróblewski, F., and La Due, J.: Transaminase Activity in Human Blood , J. Clin. Invest. , 34:126-133, 1955.Crossref 2. Schapira, G.; Dreyfus, J. C.; Schapira, F., and Kruh, J.: Glycogenolytic Enzymes in Human Progressive Muscular Dystrophy , Am. J. Phys. Med. , 35:313-319, 1955. 3. Wróblewski, F., and La Due, J.: Lactic Dehydrogenase Activity in Blood , Proc. Soc. Exp. Biol. & Med. , 90:210-213, 1955. 4. Aronson, S. M., and Volk, B. W.: Studies on Serum Aldolase Activity in Neuromuscular Disorders, I. Clinical Applications , Am. J. Med. , 22:414-421, 1957. 5. Volk, B. W.; Losner, S.; Aronson, S. M., and Lew, H.: The Serum Aldolase Level in Acute Myocardial Infarction , Am. J. Med. Sci. , 232:38-43. 1956. 6. Aronson, S. M.; Saifer, A.; Kanof, A., and Volk, B. W.: Progression of Amaurotic Family Idiocy as Reflected by Serum and Cerebrospinal Fluid Changes , Am. J. Med. , 24:390-401, 1958. 7. Aronson, S. M.; Volk, B. W., and Epstein, N.: Morphologic Evolution of Amaurotic Family Idiocy. The Protracted Phase of the Disease , Am. J. Path. , 31:609-631, 1955. 8. Sibley, J. A., and Lehninger, A. L.: Determination of Aldolase in Animal Tissues , J. Biol. Chem. , 177:859-872, 1949. 9. Bodansky, O.: Phosphohexose Isomerase in Cancer. I. Method of Determination and Establishment of Range of Normal Values , Cancer 7:1191-1199, 1954. 10. Hinsberg, K.: Der Diagnostische Wert DPN-abhängiger Enzyme , Scand. J. Clin. and Lab. Invest. 10 ( (Supplement 31) ):201-229, 1957. 11. Aronson, S. M., and Volk, B. W.: Serum Aldolase Activity in Neuromuscular Disorders, 2. Experimental Application , Proc. Soc. Exp. Biol. & Med., 94:360-363, 1957. 12. Wakim, K. G., and Fleisher, G. A.: The Effect of Experimental Cerebral Infarction on Transaminase Activity in Serum, Cerebrospinal Fluid, and Infarcted Tissue , Proc. Staff Meet., Mayo Clin. , 31:391-399, 1956. 13. Aronson, S. M.; Saifer, A.; Perle, G., and Volk, B. W.: Cerebrospinal Fluid Enzymes in Central Nervous System Lipidoses , Proc. Soc. Exp. Biol. & Med. , 97:331-334, 1958. 14. Wróblewski, F.; Decker, B., and Wróblewski, R.: Activity of Lactic Dehydrogenase in Spinal Fluid , Am. J. Clin. Path. , 28:269-271, 1957. 15. Sobotka, H.: This symposium.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1959

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