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Prognosis in Neuroblastoma of Childhood

Prognosis in Neuroblastoma of Childhood Abstract The change in the medical attitude toward prognosis in neuroblastoma of childhood received its major impetus from the reports of Farber1 and of Gross.2 Subsequent publications from other centers3-5 have amply confirmed the observation that there is a definite and significant long-term survival rate among the children with neuroblastoma. The magnitude of this survival rate appears to be influenced by several factors, among which age of the patient, presence of metastases, and degree of malignancy have been suggested. The clinical experience at The University of Texas M. D. Anderson Hospital and Tumor Institute (MDAH), however, during the period from 1951 through 1957 disclosed what appeared to be consistently unsatisfactory end-results in 15 children with neuroblastoma (Table 1). Eleven of the fifteen were dead within nine months. Only one child was living and apparently free of disease four years after diagnosis. Of three additional children who were still References 1. Farber, S.: Neuroblastoma , Am. J. Dis. Child. 60:749, 1940. 2. Gross, E.: Surgery of Infancy and Childhood , Philadelphia, W. B. Saunders Company, 1953, p. 606. 3. Beck, S. M., Jr., and Howard, P. J.: Neuroblastoma: Review of the Literature and Report of 6-Year Cure by Roentgen Therapy , A. M. A. Am. J. Dis. Child. 82:325, 1951. 4. Phillips, R.: Neuroblastoma , Ann. Roy. Coll. Surgeons 12:29, 1953. 5. Horn, R. C., Jr.; Koop, C. E., and Kiesewetter, W. B.: Neuroblastoma in Childhood: Clinicopathologic Study of 44 Cases , Lab. Invest. 5:106, 1956. 6. Ackerman, L. V., and Taylor, F. H.: Neurogenous Tumors Within the Thorax: A Clinicopathological Evaluation of 48 Cases , Cancer 4: 669, 1951.Crossref 7. Charache, H.: Tumors in Children , New York J. Med. 54:1775, 1954. 8. Oberkircher, O. J.; Staubitz, W. J., and Parmenter, F. J.: A Clinical Study of Neuroblastoma , J. Pediat. 43:177, 1953.Crossref 9. Pack, G. T.; Horning, E. D., and Ariel, I. M.: Neuroblastoma (Sympathicoblastoma) with an Analysis of 14 Cases and a Survey of the Literature , J. Neuropath. & Exper. Neurol. 11: 235, 1952. 10. Poore, T. N.; Dockerty, M. B.; Kennedy, R. L. J., and Walters, W.: Symposium on Surgical Aspects of the Cancer Problem: Abdominal Neuroblastomas , S. Clin. North America 31:1121, 1951. 11. Reiquam, C. W.; Beatty, E. C., Jr., and Allen, R. P.: Neuroblastomas in Infancy and Childhood: A Review of 10 Years' Experience , A. M. A. J. Dis. Child. 91:588, 1956. 12. Seaman, W. B., and Eagleton, M. D.: Radiation Therapy of Neuroblastoma , Radiology 68:1, 1957. 13. Snyder, W. H., Jr.; Kruse, C. A.; Greaney, E. M., and Chaffin, L.: Retroperitoneal Tumors in Infants and Children: Report of 88 Cases , A. M. A. Arch. Surg. 63:26, 1951. 14. Stowens, D.: Neuroblastoma and Related Tumors , A. M. A. Arch. Path. 63:451, 1957. 15. Uhlmann, E. M., and von Essen, C.: Neuroblastoma (Neuroblastoma Sympatheticum) , Pediatrics 15:402, 1955. 16. Wittenborg, M. H.: Roentgen Therapy in Neuroblastoma: A Review of 73 Cases , Radiology 54:679, 1950. 17. Franklin, J. E.: Analysis of Cancer in Infancy and Childhood , New York J. Med. 53: 1659, 1953. 18. Farber, S.; Toch, R.; Sears, E. M., and Pinkel, D.: Advances in Chemotherapy of Cancer in Man , Advances Cancer Res. 4:2, 1956. 19. The Treatment of Neuroblastoma with Vitamin B12 , British Empire Cancer Campaign Report, London, 1954, p. 199. 20. Collins, V. P.; Loeffler, R. K., and Tivey, H.: Observations on Growth Rates of Human Tumors , Am. J. Roentgenol. 76:988, 1956. 21. Stewart, F. W.: Factors Influencing Curability of Cancer, in Third National Cancer Conference Proceedings, Philadelphia, J. B. Lippincott Company, 1957, p. 62. 22. Shimkin, M. B.: Natural History of Neoplastic Disease , cited by Homburger, F.: The Biologic Basis of Cancer Management , New York, Paul B. Hoeber, Inc. (medical book department of Harper & Brothers), 1957, p. 155. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Prognosis in Neuroblastoma of Childhood

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060060301008
Publisher site
See Article on Publisher Site

Abstract

Abstract The change in the medical attitude toward prognosis in neuroblastoma of childhood received its major impetus from the reports of Farber1 and of Gross.2 Subsequent publications from other centers3-5 have amply confirmed the observation that there is a definite and significant long-term survival rate among the children with neuroblastoma. The magnitude of this survival rate appears to be influenced by several factors, among which age of the patient, presence of metastases, and degree of malignancy have been suggested. The clinical experience at The University of Texas M. D. Anderson Hospital and Tumor Institute (MDAH), however, during the period from 1951 through 1957 disclosed what appeared to be consistently unsatisfactory end-results in 15 children with neuroblastoma (Table 1). Eleven of the fifteen were dead within nine months. Only one child was living and apparently free of disease four years after diagnosis. Of three additional children who were still References 1. Farber, S.: Neuroblastoma , Am. J. Dis. Child. 60:749, 1940. 2. Gross, E.: Surgery of Infancy and Childhood , Philadelphia, W. B. Saunders Company, 1953, p. 606. 3. Beck, S. M., Jr., and Howard, P. J.: Neuroblastoma: Review of the Literature and Report of 6-Year Cure by Roentgen Therapy , A. M. A. Am. J. Dis. Child. 82:325, 1951. 4. Phillips, R.: Neuroblastoma , Ann. Roy. Coll. Surgeons 12:29, 1953. 5. Horn, R. C., Jr.; Koop, C. E., and Kiesewetter, W. B.: Neuroblastoma in Childhood: Clinicopathologic Study of 44 Cases , Lab. Invest. 5:106, 1956. 6. Ackerman, L. V., and Taylor, F. H.: Neurogenous Tumors Within the Thorax: A Clinicopathological Evaluation of 48 Cases , Cancer 4: 669, 1951.Crossref 7. Charache, H.: Tumors in Children , New York J. Med. 54:1775, 1954. 8. Oberkircher, O. J.; Staubitz, W. J., and Parmenter, F. J.: A Clinical Study of Neuroblastoma , J. Pediat. 43:177, 1953.Crossref 9. Pack, G. T.; Horning, E. D., and Ariel, I. M.: Neuroblastoma (Sympathicoblastoma) with an Analysis of 14 Cases and a Survey of the Literature , J. Neuropath. & Exper. Neurol. 11: 235, 1952. 10. Poore, T. N.; Dockerty, M. B.; Kennedy, R. L. J., and Walters, W.: Symposium on Surgical Aspects of the Cancer Problem: Abdominal Neuroblastomas , S. Clin. North America 31:1121, 1951. 11. Reiquam, C. W.; Beatty, E. C., Jr., and Allen, R. P.: Neuroblastomas in Infancy and Childhood: A Review of 10 Years' Experience , A. M. A. J. Dis. Child. 91:588, 1956. 12. Seaman, W. B., and Eagleton, M. D.: Radiation Therapy of Neuroblastoma , Radiology 68:1, 1957. 13. Snyder, W. H., Jr.; Kruse, C. A.; Greaney, E. M., and Chaffin, L.: Retroperitoneal Tumors in Infants and Children: Report of 88 Cases , A. M. A. Arch. Surg. 63:26, 1951. 14. Stowens, D.: Neuroblastoma and Related Tumors , A. M. A. Arch. Path. 63:451, 1957. 15. Uhlmann, E. M., and von Essen, C.: Neuroblastoma (Neuroblastoma Sympatheticum) , Pediatrics 15:402, 1955. 16. Wittenborg, M. H.: Roentgen Therapy in Neuroblastoma: A Review of 73 Cases , Radiology 54:679, 1950. 17. Franklin, J. E.: Analysis of Cancer in Infancy and Childhood , New York J. Med. 53: 1659, 1953. 18. Farber, S.; Toch, R.; Sears, E. M., and Pinkel, D.: Advances in Chemotherapy of Cancer in Man , Advances Cancer Res. 4:2, 1956. 19. The Treatment of Neuroblastoma with Vitamin B12 , British Empire Cancer Campaign Report, London, 1954, p. 199. 20. Collins, V. P.; Loeffler, R. K., and Tivey, H.: Observations on Growth Rates of Human Tumors , Am. J. Roentgenol. 76:988, 1956. 21. Stewart, F. W.: Factors Influencing Curability of Cancer, in Third National Cancer Conference Proceedings, Philadelphia, J. B. Lippincott Company, 1957, p. 62. 22. Shimkin, M. B.: Natural History of Neoplastic Disease , cited by Homburger, F.: The Biologic Basis of Cancer Management , New York, Paul B. Hoeber, Inc. (medical book department of Harper & Brothers), 1957, p. 155.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Sep 1, 1958

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