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Pheochromocytoma in a Boy Aged Ten Years

Pheochromocytoma in a Boy Aged Ten Years Abstract Pheochromocytoma is a tumor originating from chromaffin tissue, most frequently from the medulla of the adrenal gland. It secretes epinephrine and norepinephrine in variable amounts. The tumor is usually benign and occasionally malignant.1 The majority of the tumors are unilateral without predilection for either side. Some are bilateral7 and some extra-adrenal. Pheochromocytoma in childhood is rare but should be considered if renal disease can be excluded as the cause of hypertension.9,15,19 The hypertension, which can be either sustained13 or paroxysmal, is due to circulating norepinephrine. In a recent review of the literature16 Smid and Du Shane (1955) cite a total of 32 cases of pheochromocytoma in children of 14 years and under reported since 1910 of whom 9 were girls and 22 were boys. The sex is not stated in one case in which a medullary tumor was found at autopsy. The youngest child was References 1. Davis, P.; Peart, W. S., and van't Hoff, W.: Malignant Phaeochromocytoma with Functioning Metastases , Lancet 2:274-275 ( (Aug. 6) ) 1955.Crossref 2. Fraser, H. R. L.; Turner, R. W. D., and Band, D.: Phaeochromocytoma of the Adrenal with Paroxismal Hypertension, Brit. J. Urol. 27: 272-284 ( (Sept.) ) 1955.Crossref 3. Gifford, R. W., Jr.; Roth, G. M., and Kvale, W. F.: Evaluation of New Adrenolytic Drug (Regitine) as Test for Pheochromocytoma , J. A. M. A. 149:1628 ( (Aug.) ) 1952.Crossref 4. Goldenberg, M.; Serlin, I.; Edwards, T., and Rapport, M. M.: Chemical Screening Methods for the Diagnosis of Pheochromocytoma: Nor-Epinephrine and Epinephrine in Human Urine , Am. J. Med. 16:310 ( (March) ) 1954.Crossref 5. Graham, J. B.: Pheochromocytoma and Hypertension: Analysis of 207 Cases , Internat. Abstr. Surg. 92:105 ( (Feb.) ) 1951. 6. Helps, E. P.; Robinson, K. C., and Ross, E. J.: Phentolamine in the Diagnosis and Management of Phaeochromocytoma , Lancet 2:267-273 ( (Aug. 6) ) 1955.Crossref 7. Kelsall, A. R., and Ross, E. J.: Bilateral Phaeochromocytoma in 2 Sisters , Lancet 2:273-274 ( (Aug. 6) ) 1955.Crossref 8. Kvale, W. F.; Priestley, J. T., and Roth, G. M.: Pheochromocytoma: Clinical Aspects and Surgical Results , A. M. A. Arch. Surg. 68:769-788 ( (June) ) 1954.Crossref 9. Moore, T. C., and Shumacker, H. B., Jr.: Adrenalin Producing Tumors in Childhood , Ann. Surg. 143:256-265 ( (Feb.) ) 1956. 10. Morris, J. C., and others: Some Current Opinions on Phaeochromocytoma and an Illustrative Case Report , M. J. Australia 41:981-986 ( (June 26) ) 1954. 11. Moulton, R., and Willoughby, D. A.: Short Laboratory Screening Test for Phaeochromocytoma , Lancet 2:16-18 ( (July 2) ) 1955.Crossref 12. Palmer, K. N. V., and McDonald, G. A.: Phaeochromocytoma with Sustained Hypertension , Brit. M. J. 1:957-960 ( (April 28) ) 1956.Crossref 13. Richardson, J. E.; Ross, J. E., and Turnbull, A. L.: Reversal of Malignant Hypertension Due to Ectopic Phaeochromocytoma , Lancet 2:275-278 ( (Aug. 6) ) 1955.Crossref 14. Rosenheim, M. L.: The Treatment of Severe Hypertension , Brit. M. J. 2:1181-1193 ( (Nov. 20) ) 1954.Crossref 15. Schwab, L.: The Diagnosis of Phaeochromocytoma in Children: A Pediatric Review , Ohio M. J. 52:259-260 ( (March) ) 1956. 16. Smid, A. C., and Dushane, J. W.: Pheochromocytoma in Children: Report of a Case , A. M. A. Am. J. Dis. Child. 90:81-88 ( (July) ) 1955. 17. Snyder, C. H., and Rutledge, L. J.: Phaeochromocytoma: Localization by Aortography , Pediatrics 15:312-316 ( (March) ) 1955. 18. Spencer, B. J.; Wyatt, O. S., and Chisholm, T. C.: Phaeochromocytoma in a 7-Year-Old Girl: Report of Successful Removal , Minnesota Med. 39:220-222 (April) 1956. 19. Tevetoglu, F., and Lee, C. H.: Adrenal Pheochromocytoma Simulating Diabetes Insipidus: Report of a Case and Review of the Other Pediatric Cases , A. M. A. Am. J. Dis. Child. 91:365-379 ( (April) ) 1956.Crossref 20. West, G. B., and Taylor, N. R. W.: Studies in Phaeochromocytoma: III. Excretion of Noradrenaline in the Urine of Cases of Hypertension, and Its Value in the Diagnosis of Phaeochromocytoma , Glasgow M. J. 36:123-129 ( (April) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Pheochromocytoma in a Boy Aged Ten Years

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Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1957.02060040532006
Publisher site
See Article on Publisher Site

Abstract

Abstract Pheochromocytoma is a tumor originating from chromaffin tissue, most frequently from the medulla of the adrenal gland. It secretes epinephrine and norepinephrine in variable amounts. The tumor is usually benign and occasionally malignant.1 The majority of the tumors are unilateral without predilection for either side. Some are bilateral7 and some extra-adrenal. Pheochromocytoma in childhood is rare but should be considered if renal disease can be excluded as the cause of hypertension.9,15,19 The hypertension, which can be either sustained13 or paroxysmal, is due to circulating norepinephrine. In a recent review of the literature16 Smid and Du Shane (1955) cite a total of 32 cases of pheochromocytoma in children of 14 years and under reported since 1910 of whom 9 were girls and 22 were boys. The sex is not stated in one case in which a medullary tumor was found at autopsy. The youngest child was References 1. Davis, P.; Peart, W. S., and van't Hoff, W.: Malignant Phaeochromocytoma with Functioning Metastases , Lancet 2:274-275 ( (Aug. 6) ) 1955.Crossref 2. Fraser, H. R. L.; Turner, R. W. D., and Band, D.: Phaeochromocytoma of the Adrenal with Paroxismal Hypertension, Brit. J. Urol. 27: 272-284 ( (Sept.) ) 1955.Crossref 3. Gifford, R. W., Jr.; Roth, G. M., and Kvale, W. F.: Evaluation of New Adrenolytic Drug (Regitine) as Test for Pheochromocytoma , J. A. M. A. 149:1628 ( (Aug.) ) 1952.Crossref 4. Goldenberg, M.; Serlin, I.; Edwards, T., and Rapport, M. M.: Chemical Screening Methods for the Diagnosis of Pheochromocytoma: Nor-Epinephrine and Epinephrine in Human Urine , Am. J. Med. 16:310 ( (March) ) 1954.Crossref 5. Graham, J. B.: Pheochromocytoma and Hypertension: Analysis of 207 Cases , Internat. Abstr. Surg. 92:105 ( (Feb.) ) 1951. 6. Helps, E. P.; Robinson, K. C., and Ross, E. J.: Phentolamine in the Diagnosis and Management of Phaeochromocytoma , Lancet 2:267-273 ( (Aug. 6) ) 1955.Crossref 7. Kelsall, A. R., and Ross, E. J.: Bilateral Phaeochromocytoma in 2 Sisters , Lancet 2:273-274 ( (Aug. 6) ) 1955.Crossref 8. Kvale, W. F.; Priestley, J. T., and Roth, G. M.: Pheochromocytoma: Clinical Aspects and Surgical Results , A. M. A. Arch. Surg. 68:769-788 ( (June) ) 1954.Crossref 9. Moore, T. C., and Shumacker, H. B., Jr.: Adrenalin Producing Tumors in Childhood , Ann. Surg. 143:256-265 ( (Feb.) ) 1956. 10. Morris, J. C., and others: Some Current Opinions on Phaeochromocytoma and an Illustrative Case Report , M. J. Australia 41:981-986 ( (June 26) ) 1954. 11. Moulton, R., and Willoughby, D. A.: Short Laboratory Screening Test for Phaeochromocytoma , Lancet 2:16-18 ( (July 2) ) 1955.Crossref 12. Palmer, K. N. V., and McDonald, G. A.: Phaeochromocytoma with Sustained Hypertension , Brit. M. J. 1:957-960 ( (April 28) ) 1956.Crossref 13. Richardson, J. E.; Ross, J. E., and Turnbull, A. L.: Reversal of Malignant Hypertension Due to Ectopic Phaeochromocytoma , Lancet 2:275-278 ( (Aug. 6) ) 1955.Crossref 14. Rosenheim, M. L.: The Treatment of Severe Hypertension , Brit. M. J. 2:1181-1193 ( (Nov. 20) ) 1954.Crossref 15. Schwab, L.: The Diagnosis of Phaeochromocytoma in Children: A Pediatric Review , Ohio M. J. 52:259-260 ( (March) ) 1956. 16. Smid, A. C., and Dushane, J. W.: Pheochromocytoma in Children: Report of a Case , A. M. A. Am. J. Dis. Child. 90:81-88 ( (July) ) 1955. 17. Snyder, C. H., and Rutledge, L. J.: Phaeochromocytoma: Localization by Aortography , Pediatrics 15:312-316 ( (March) ) 1955. 18. Spencer, B. J.; Wyatt, O. S., and Chisholm, T. C.: Phaeochromocytoma in a 7-Year-Old Girl: Report of Successful Removal , Minnesota Med. 39:220-222 (April) 1956. 19. Tevetoglu, F., and Lee, C. H.: Adrenal Pheochromocytoma Simulating Diabetes Insipidus: Report of a Case and Review of the Other Pediatric Cases , A. M. A. Am. J. Dis. Child. 91:365-379 ( (April) ) 1956.Crossref 20. West, G. B., and Taylor, N. R. W.: Studies in Phaeochromocytoma: III. Excretion of Noradrenaline in the Urine of Cases of Hypertension, and Its Value in the Diagnosis of Phaeochromocytoma , Glasgow M. J. 36:123-129 ( (April) ) 1955.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1957

References