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Pertussis: A Clinical Study

Pertussis: A Clinical Study Abstract Although in recent years pediatricians have turned their attention away from the common infectious diseases of childhood, pertussis is still a significant and dangerous disease, causing more deaths in the first year of life than measles, scarlet fever, diphtheria, and poliomyelitis combined.1,2 In 1955, there were 467 deaths due to pertussis reported in 62,786 cases of the disease in the United States.2 With the reduction of the danger of secondary bacterial complications through the use of appropriate antibiotics, the mortality rate has been reduced markedly. The symptomatology of pertussis has also been altered significantly by the advent of improved symptomatic care, chemotherapy, and mass immunization. Our study comprises a review of all cases of pertussis admitted to the San Francisco General Hospital during a 10½-year period. We have found no comparable, study in the recent American literature. Clinical Findings During the period from July 1, 1947, to Jan. References 1. Jernelius, H.: Pertussis Complications and Mortality During the Period 1934 to 1953 , Acta paediat. 47:56-64 ( (Jan.) ) 1958.Crossref 2. Miles, J. V.: Pertussis , J. Lancet 79:49-56 ( (Feb.) ) 1959. 3. Bradford, W.: Parapertussis , in Essays in Pediatrics in Honor of Irvine McQuarrie , R. A. Good and E. S. Platou, Editors, Minneapolis, Lancet Publication, Inc., 1955, pp. 66-68. 4. Brainerd, H.: The Treatment of Pertussis and Pneumonia Complicating Pertussis: The Role of Hyperimmune Gamma Globulin and Sulfadiazine , J. Pediat. 32:30-34 ( (Jan.) ) 1948.Crossref 5. Ames, R. G.; Cohen, S. M.; Fischer, A. E.; Kohn, J.; McPherson, A. Z.; Marlow, J.; Rutzky, J., and Alexander, H.: Comparison of the Therapeutic Efficacy of 4 Agents in Pertussis , Pediatrics 11:323-337 ( (April) ) 1953. 6. Lucchesi, P. F., and LaBoccette, A. C.: Whooping Cough Treated with Pertussis Immune Serum (Human): Report on a Controlled Series of 52 Patients Under One Year of Age , Am. J. Dis. Child. 77:15-24 ( (Jan.) ) 1949.Crossref 7. Hazen, L. N.; Jackson, G. G.; Shih-Man, C.; Place, E. H., and Finland, M.: Antibiotic Treatment of Pertussis , J. Pediat. 39:1-15 ( (July) ) 1951.Crossref 8. Weinstein, L.; Seltser, R., and Marrow, C. T., III: The Treatment of Pertussis with Aureomycin, Chloramphenicol, and Terramycin , J. Pediat. 39:549-559 ( (Nov.) ) 1951.Crossref 9. Sako, W.: Studies on Pertussis Immunization , J. Pediat. 30:29-40 ( (Jan.) ) 1947.Crossref 10. Lippsett, S. M.; Bloch, H.; Miller, I.; Stein, F., and Lippsett, H. L.: Immunization of Newborn Infants with Pertussis Vaccine , J. Pediat. 42:301-303 ( (March) ) 1953.Crossref 11. Pertussis, in Report of the Committee on the Control of Infectious Diseases, American Academy of Pediatrics, 1955, p. 8. 12. Jaffe, V. R.: Incidence of Pertussis in Vaccinated and Unvaccinated Children: Report of 100 Cases Followed in a Child Health Clinic , J. Pediat. 47:716-719 ( (Dec.) ) 1955.Crossref 13. Madsen, T.: Vaccination Against Whooping Cough , J. A.M.A. 101:187-188 ( (July 15) ) 1933. 14. Bell, J. A.: Pertussis Immunization: Use of 2 Doses of an Alum-Precipitated Mixture of Diphtheria Toxoid and Pertussis Vaccine , J.A.M.A. 137:1276-1281 ( (Aug. 7) ) 1948.Crossref 15. Kendrick, P. L.: Secondary Familial Attack Rates from Pertussis in Vaccinated and Unvaccinated Children , Am. J. Hyg. 32:89-91 ( (Nov.) ) 1940. 16. di Sant'Agnese, P. A.: Combined Immunization Against Diphtheria, Tetanus, and Pertussis in Newborn Infants: I. Production of Antibodies in Early Infancy , Pediatrics 3:20-33 ( (Jan.) ) 1949. 17. Miller, J. J., Jr.; Faber, H. K.; Ryan, M. L.; Silverberg, R. J., and Lew, E.: Immunization Against Pertussis During the First 4 Months of Life , Pediatrics 4:468-478 ( (Oct.) ) 1949. 18. Felton, H. M.: Pertussis: Current Status of Prevention and Treatment , Pediat. Clin. North America February , 1957, pp. 271-283. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

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References (23)

Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030419003
Publisher site
See Article on Publisher Site

Abstract

Abstract Although in recent years pediatricians have turned their attention away from the common infectious diseases of childhood, pertussis is still a significant and dangerous disease, causing more deaths in the first year of life than measles, scarlet fever, diphtheria, and poliomyelitis combined.1,2 In 1955, there were 467 deaths due to pertussis reported in 62,786 cases of the disease in the United States.2 With the reduction of the danger of secondary bacterial complications through the use of appropriate antibiotics, the mortality rate has been reduced markedly. The symptomatology of pertussis has also been altered significantly by the advent of improved symptomatic care, chemotherapy, and mass immunization. Our study comprises a review of all cases of pertussis admitted to the San Francisco General Hospital during a 10½-year period. We have found no comparable, study in the recent American literature. Clinical Findings During the period from July 1, 1947, to Jan. References 1. Jernelius, H.: Pertussis Complications and Mortality During the Period 1934 to 1953 , Acta paediat. 47:56-64 ( (Jan.) ) 1958.Crossref 2. Miles, J. V.: Pertussis , J. Lancet 79:49-56 ( (Feb.) ) 1959. 3. Bradford, W.: Parapertussis , in Essays in Pediatrics in Honor of Irvine McQuarrie , R. A. Good and E. S. Platou, Editors, Minneapolis, Lancet Publication, Inc., 1955, pp. 66-68. 4. Brainerd, H.: The Treatment of Pertussis and Pneumonia Complicating Pertussis: The Role of Hyperimmune Gamma Globulin and Sulfadiazine , J. Pediat. 32:30-34 ( (Jan.) ) 1948.Crossref 5. Ames, R. G.; Cohen, S. M.; Fischer, A. E.; Kohn, J.; McPherson, A. Z.; Marlow, J.; Rutzky, J., and Alexander, H.: Comparison of the Therapeutic Efficacy of 4 Agents in Pertussis , Pediatrics 11:323-337 ( (April) ) 1953. 6. Lucchesi, P. F., and LaBoccette, A. C.: Whooping Cough Treated with Pertussis Immune Serum (Human): Report on a Controlled Series of 52 Patients Under One Year of Age , Am. J. Dis. Child. 77:15-24 ( (Jan.) ) 1949.Crossref 7. Hazen, L. N.; Jackson, G. G.; Shih-Man, C.; Place, E. H., and Finland, M.: Antibiotic Treatment of Pertussis , J. Pediat. 39:1-15 ( (July) ) 1951.Crossref 8. Weinstein, L.; Seltser, R., and Marrow, C. T., III: The Treatment of Pertussis with Aureomycin, Chloramphenicol, and Terramycin , J. Pediat. 39:549-559 ( (Nov.) ) 1951.Crossref 9. Sako, W.: Studies on Pertussis Immunization , J. Pediat. 30:29-40 ( (Jan.) ) 1947.Crossref 10. Lippsett, S. M.; Bloch, H.; Miller, I.; Stein, F., and Lippsett, H. L.: Immunization of Newborn Infants with Pertussis Vaccine , J. Pediat. 42:301-303 ( (March) ) 1953.Crossref 11. Pertussis, in Report of the Committee on the Control of Infectious Diseases, American Academy of Pediatrics, 1955, p. 8. 12. Jaffe, V. R.: Incidence of Pertussis in Vaccinated and Unvaccinated Children: Report of 100 Cases Followed in a Child Health Clinic , J. Pediat. 47:716-719 ( (Dec.) ) 1955.Crossref 13. Madsen, T.: Vaccination Against Whooping Cough , J. A.M.A. 101:187-188 ( (July 15) ) 1933. 14. Bell, J. A.: Pertussis Immunization: Use of 2 Doses of an Alum-Precipitated Mixture of Diphtheria Toxoid and Pertussis Vaccine , J.A.M.A. 137:1276-1281 ( (Aug. 7) ) 1948.Crossref 15. Kendrick, P. L.: Secondary Familial Attack Rates from Pertussis in Vaccinated and Unvaccinated Children , Am. J. Hyg. 32:89-91 ( (Nov.) ) 1940. 16. di Sant'Agnese, P. A.: Combined Immunization Against Diphtheria, Tetanus, and Pertussis in Newborn Infants: I. Production of Antibodies in Early Infancy , Pediatrics 3:20-33 ( (Jan.) ) 1949. 17. Miller, J. J., Jr.; Faber, H. K.; Ryan, M. L.; Silverberg, R. J., and Lew, E.: Immunization Against Pertussis During the First 4 Months of Life , Pediatrics 4:468-478 ( (Oct.) ) 1949. 18. Felton, H. M.: Pertussis: Current Status of Prevention and Treatment , Pediat. Clin. North America February , 1957, pp. 271-283.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1960

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