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Mucormycosis of the Central Nervous System

Mucormycosis of the Central Nervous System Abstract For many years Mucor and Rhizopus, class of Phycomycetes, have been considered purely saprophytic, but recently a number of cases of human infection by these organisms have been encountered. Fourteen cases1-11 with involvement of the brain have been reported, and nine2,3,7,9-11 of these had concomitant disease of the eyes. In each of these 14 cases the fungus infection complicated some other disorder, and all of the patients died of their fungal disease. In one other case the eye alone was involved and treatment by enucleation was successful.12 Paultauf1 reported the first case with central nervous system involvement in 1885, but no other cases appear until 1943, when Gregory, Golden, and Haymaker2 reported three new cases, all in middle-aged diabetics who were in diabetic coma when first seen. Subsequently LeCompte and Meissner,3 Wolf and Cowen,4 and Stratemeier5 reported single cases, each in moribund References 1. Paultauf, A.: Mycosis mucorina , Arch. path. Anat. 102:543-564 ( (Dec.) ) 1885.Crossref 2. Gregory, J. E.; Golden, A., and Haymaker, W.: Mucormycosis of the Central Nervous System: Report of 3 Cases , Bull. Johns Hopkins Hosp. 73:405-415 ( (Dec.) ) 1943. 3. LeCompte, P. M., and Meissner, W. A.: Mucormycosis of the Central Nervous System Associated with Hemochromatosis , Am. J. Path. 23: 673-676 ( (July) ) 1947. 4. Wolf, A., and Cowen, D.: Mucormycosis of the Central Nervous System , J. Neuropath. & Exper. Neurol. 8:107 ( (Jan.) ) 1949. 5. Stratemeier, W. P.: Mucormycosis of the Central Nervous System: Report of a Case , Arch. Neurol. & Psychiat. 63:179-180 ( (Jan.) ) 1950. 6. Baker, R. D., and Severance, A. O.: Mucormycosis with Report of Acute Mycotic Pneumonia , Am. J. Path. 24:716-717 ( (March) ) 1948. 7. Martin, F. P.; Lukeman, J. M.; Ranson, R. F., and Geppert, L. J.: Mucormycosis of the Central Nervous System Associated with Thrombosis of the Internal Carotid Artery , J. Pediat. 44:437-442 ( (April) ) 1954. 8. Kurrein, F.: Cerebral Mucormycosis , J. Clin. Path. 7:141-144 ( (May) ) 1954. 9. Gunson, H. H., and Bowden, D. H.: Cerebral Mucormycosis: Report of a Case , A. M. A. Arch. Path. 60:440-443 ( (Oct.) ) 1955. 10. Bauer, H.; Ajello, L.; Adams, E., and Useda Hernandez, D.: Cerebral Mucormycosis: Pathogenesis of Disease; Description of Fungus, Rhizopus Oryzae, Isolated from Fatal Case , Am. J. Med. 18:822-831 ( (May) ) 1955. 11. Harris, J. S.: Mucormycosis: Report of a Case , Pediatrics 16:857-867 ( (Dec.) ) 1955. 12. Wadsworth, J. A. C.: Ocular Mucormycosis: Report of a Case , Am. J. Ophth. 34:405-409 ( (March) ) 1951. 13. Zimmerman, L. E.: Fatal Fungus Infections Complicating Other Diseases , Am. J. Clin. Path. 25:46-65 ( (Jan.) ) 1955. 14. Bauer, H.; Flanagan, J. F., and Sheldon, W. H.: Experimental Cerebral Mucormycosis in Rabbits with Alloxan Diabetes , Yale J. Biol. & Med. 28:29-36 ( (Sept.) ) 1955. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Mucormycosis of the Central Nervous System

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1959.02070010854013
Publisher site
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Abstract

Abstract For many years Mucor and Rhizopus, class of Phycomycetes, have been considered purely saprophytic, but recently a number of cases of human infection by these organisms have been encountered. Fourteen cases1-11 with involvement of the brain have been reported, and nine2,3,7,9-11 of these had concomitant disease of the eyes. In each of these 14 cases the fungus infection complicated some other disorder, and all of the patients died of their fungal disease. In one other case the eye alone was involved and treatment by enucleation was successful.12 Paultauf1 reported the first case with central nervous system involvement in 1885, but no other cases appear until 1943, when Gregory, Golden, and Haymaker2 reported three new cases, all in middle-aged diabetics who were in diabetic coma when first seen. Subsequently LeCompte and Meissner,3 Wolf and Cowen,4 and Stratemeier5 reported single cases, each in moribund References 1. Paultauf, A.: Mycosis mucorina , Arch. path. Anat. 102:543-564 ( (Dec.) ) 1885.Crossref 2. Gregory, J. E.; Golden, A., and Haymaker, W.: Mucormycosis of the Central Nervous System: Report of 3 Cases , Bull. Johns Hopkins Hosp. 73:405-415 ( (Dec.) ) 1943. 3. LeCompte, P. M., and Meissner, W. A.: Mucormycosis of the Central Nervous System Associated with Hemochromatosis , Am. J. Path. 23: 673-676 ( (July) ) 1947. 4. Wolf, A., and Cowen, D.: Mucormycosis of the Central Nervous System , J. Neuropath. & Exper. Neurol. 8:107 ( (Jan.) ) 1949. 5. Stratemeier, W. P.: Mucormycosis of the Central Nervous System: Report of a Case , Arch. Neurol. & Psychiat. 63:179-180 ( (Jan.) ) 1950. 6. Baker, R. D., and Severance, A. O.: Mucormycosis with Report of Acute Mycotic Pneumonia , Am. J. Path. 24:716-717 ( (March) ) 1948. 7. Martin, F. P.; Lukeman, J. M.; Ranson, R. F., and Geppert, L. J.: Mucormycosis of the Central Nervous System Associated with Thrombosis of the Internal Carotid Artery , J. Pediat. 44:437-442 ( (April) ) 1954. 8. Kurrein, F.: Cerebral Mucormycosis , J. Clin. Path. 7:141-144 ( (May) ) 1954. 9. Gunson, H. H., and Bowden, D. H.: Cerebral Mucormycosis: Report of a Case , A. M. A. Arch. Path. 60:440-443 ( (Oct.) ) 1955. 10. Bauer, H.; Ajello, L.; Adams, E., and Useda Hernandez, D.: Cerebral Mucormycosis: Pathogenesis of Disease; Description of Fungus, Rhizopus Oryzae, Isolated from Fatal Case , Am. J. Med. 18:822-831 ( (May) ) 1955. 11. Harris, J. S.: Mucormycosis: Report of a Case , Pediatrics 16:857-867 ( (Dec.) ) 1955. 12. Wadsworth, J. A. C.: Ocular Mucormycosis: Report of a Case , Am. J. Ophth. 34:405-409 ( (March) ) 1951. 13. Zimmerman, L. E.: Fatal Fungus Infections Complicating Other Diseases , Am. J. Clin. Path. 25:46-65 ( (Jan.) ) 1955. 14. Bauer, H.; Flanagan, J. F., and Sheldon, W. H.: Experimental Cerebral Mucormycosis in Rabbits with Alloxan Diabetes , Yale J. Biol. & Med. 28:29-36 ( (Sept.) ) 1955.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1959

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