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Metastatic Embryonal Rhabdomyosarcoma in the Growing Skeleton: Clinical, Radiographic, and Microscopic Features

Metastatic Embryonal Rhabdomyosarcoma in the Growing Skeleton: Clinical, Radiographic, and... Abstract In 1946 Stout published his classical paper1 on rhabdomyosarcoma of skeletal muscles, which established, for the first time, the microscopic characteristics of sarcomas of skeletal muscles in the absence of demonstrable cross striations. Stobbe and Dargeon3 pointed out, in 1950, that the embryonic type of rhabdomyosarcoma of the head and neck in children resembled neuroblastoma and lymphosarcoma. They reported 15 patients with a mean age of 6½ years but who varied in age from 16 months to 16 years; 13 of their patients were 12 years old or younger. In these cases limited to the head and neck, the primary rhabdomyosarcomas developed in orbital, facial, and cervical muscles. The authors state that clinically these tumors were rarely diagnosed early and were often misdiagnosed microscopically. Distant metastases occurred in several sites in 6 of 15 cases: lungs in 4 cases, pleuras in 3 cases, lymph nodes in 3, vertebral References 1. Stout, A. P.: Rhabdomyosarcoma of Skeletal Muscle , Ann. Surg. 123:447, 1946.Crossref 2. Stout, A. P.: Tumors of the Soft Tissues, Atlas of Tumor Pathology , Sec. 2, Fasc. 5, Armed Forces Institute of Pathology, Washington, D. C., 1953. 3. Stobbe, G. D., and Dargeon, H. W.: Embryonal Rhabdomyosarcoma of Head and Neck in Children , Cancer 3:826, 1950.Crossref 4. Horn, R. C., Jr., and Enterline, H. T.: Rhabdomyosarcoma: A Clinicopathologic Study and Classification of 39 Cases , Cancer 11:181, 1958.Crossref 5. Pack, A. T., and Eberhart, W. F.: Rhabdomyosarcoma of Skeletal Muscle , Surgery 32: 1023, 1952. 6. Andersen, D. H.: Tumors of Infancy and Childhood , Cancer 4:890, 1951.Crossref 7. Hansman, C. F., and Girdany, B. R.: Roentgenographic Findings Associated with Neuroblastoma , J. Pediat. 51:621, 1957.Crossref 8. Kincaid, O. W., and others: Neuroblastoma: A Roentgenologic and Pathologic Study , Am. J. Roentgenol. 78:420, 1957. 9. Sherman, R. S., and Leaming, R.: The Roentgen Findings in Neuroblastoma , Radiology 60:837, 1953.Crossref 10. Wittenborg, M. H.: Roentgen Therapy of Neuroblastoma: A Review of 73 Cases , Radiology 54:629, 1950.Crossref 11. Jacobsen, V. C., and Hosoi, K.: Primary Sympathicoblastoma of the Skin of the Thigh , Am. J. Path. 6:427, 1930. 12. Fahey, J. J., and Bollinger, J. A.: Congenital Sarcoma of the Foot: Case Report and Review of Literature , A. M. A. Am. J. Dis. Child. 86: 23, 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Metastatic Embryonal Rhabdomyosarcoma in the Growing Skeleton: Clinical, Radiographic, and Microscopic Features

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060050585001
Publisher site
See Article on Publisher Site

Abstract

Abstract In 1946 Stout published his classical paper1 on rhabdomyosarcoma of skeletal muscles, which established, for the first time, the microscopic characteristics of sarcomas of skeletal muscles in the absence of demonstrable cross striations. Stobbe and Dargeon3 pointed out, in 1950, that the embryonic type of rhabdomyosarcoma of the head and neck in children resembled neuroblastoma and lymphosarcoma. They reported 15 patients with a mean age of 6½ years but who varied in age from 16 months to 16 years; 13 of their patients were 12 years old or younger. In these cases limited to the head and neck, the primary rhabdomyosarcomas developed in orbital, facial, and cervical muscles. The authors state that clinically these tumors were rarely diagnosed early and were often misdiagnosed microscopically. Distant metastases occurred in several sites in 6 of 15 cases: lungs in 4 cases, pleuras in 3 cases, lymph nodes in 3, vertebral References 1. Stout, A. P.: Rhabdomyosarcoma of Skeletal Muscle , Ann. Surg. 123:447, 1946.Crossref 2. Stout, A. P.: Tumors of the Soft Tissues, Atlas of Tumor Pathology , Sec. 2, Fasc. 5, Armed Forces Institute of Pathology, Washington, D. C., 1953. 3. Stobbe, G. D., and Dargeon, H. W.: Embryonal Rhabdomyosarcoma of Head and Neck in Children , Cancer 3:826, 1950.Crossref 4. Horn, R. C., Jr., and Enterline, H. T.: Rhabdomyosarcoma: A Clinicopathologic Study and Classification of 39 Cases , Cancer 11:181, 1958.Crossref 5. Pack, A. T., and Eberhart, W. F.: Rhabdomyosarcoma of Skeletal Muscle , Surgery 32: 1023, 1952. 6. Andersen, D. H.: Tumors of Infancy and Childhood , Cancer 4:890, 1951.Crossref 7. Hansman, C. F., and Girdany, B. R.: Roentgenographic Findings Associated with Neuroblastoma , J. Pediat. 51:621, 1957.Crossref 8. Kincaid, O. W., and others: Neuroblastoma: A Roentgenologic and Pathologic Study , Am. J. Roentgenol. 78:420, 1957. 9. Sherman, R. S., and Leaming, R.: The Roentgen Findings in Neuroblastoma , Radiology 60:837, 1953.Crossref 10. Wittenborg, M. H.: Roentgen Therapy of Neuroblastoma: A Review of 73 Cases , Radiology 54:629, 1950.Crossref 11. Jacobsen, V. C., and Hosoi, K.: Primary Sympathicoblastoma of the Skin of the Thigh , Am. J. Path. 6:427, 1930. 12. Fahey, J. J., and Bollinger, J. A.: Congenital Sarcoma of the Foot: Case Report and Review of Literature , A. M. A. Am. J. Dis. Child. 86: 23, 1953.

Journal

A.M.A. Journal of Diseases of Children – American Medical Association

Published: Jun 1, 1958

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