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Measles Meningoencephalitis: A Summary of Twenty-Four Cases Treated at Grasslands over a Ten-Year Period

Measles Meningoencephalitis: A Summary of Twenty-Four Cases Treated at Grasslands over a Ten-Year... Abstract Introduction The central nervous system complications of measles were recognized as early as 1872, when Westphal first used the term acute disseminated encephalomyelitis. Measles encephalitis as a clinical entity was very adequately described by Neal and Appelbaum, in 1927,4 and by Musser and Hauser, in 1928.7 An increasing interest in the subject of measles encephalitis in recent years has stimulated a search for some form of specific therapy. In 1952, corticotropin (ACTH) was first tried in a series of patients by Appelbaum, at Willard Parker.* Gamma-globulin has subsequently been tried in the treatment of measles encephalitis; however, experience has indicated that it is not an effective therapeutic agent.6The purpose of this presentation is to summarize the experience over a 10-year period with measles meningoencephalitis occurring in the pediatric age group at Grasslands Hospital. There have been 24 diagnosed cases of measles meningoencephalitis treated here since 1945, References 1. Ford, F. R.: Diseases of the Nervous System in Infancy , Childhood and Adolescence , Ed. 3, Springfield, Ill., Charles C Thomas, Publisher, 1952. 2. Malamud, N.: Sequelae of Postmeasles Encephalomyelitis: A Clinicopthologic Study , Arch. Neurol. & Psychiat. 41:943-954 ( (May) ) 1939. 3. Gesell, A.: Growth and Development: Trends Toward a Clinical Science of Child Development , in the 1950 Year Book of Pediatrics (July, 1949-July, 1950) , edited by H. G. Poncher, Chicago, The Year Book Publishers, Inc., 1950, p. 371. 4. Neal, J. B., and Appelbaum, E.: Encephalitis Associated with Measles , J.A.M.A. 88:1552-1554 ( (May 14) ) 1927. 5. Solomons, G.; Markman, C. A., and West, E. J.: Measles Encephalitis , Pediatrics 11:473-478 ( (May) ) 1953. 6. Greenberg, M.; Appelbaum, E.; Pellitteri, O., and Eisenstein, D. T.: Measles Encephalitis: II. Treatment with Gamma Globulin , J. Pediat. 46:648-653 ( (June) ) 1955. 7. Musser, J. H., and Hauser, G. H.: Encephalitis as a Complication of Measles , J. A. M. A. 90:1267-1270 ( (April 21) ) 1928. 8. Allen, J. E., and Frank, D. J.: The Use of Gamma Globulin in the Treatment of Measles Encephalitis , Pediatrics 17:78-83 ( (Jan.) ) 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Measles Meningoencephalitis: A Summary of Twenty-Four Cases Treated at Grasslands over a Ten-Year Period

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References (8)

Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1956.02060030266004
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction The central nervous system complications of measles were recognized as early as 1872, when Westphal first used the term acute disseminated encephalomyelitis. Measles encephalitis as a clinical entity was very adequately described by Neal and Appelbaum, in 1927,4 and by Musser and Hauser, in 1928.7 An increasing interest in the subject of measles encephalitis in recent years has stimulated a search for some form of specific therapy. In 1952, corticotropin (ACTH) was first tried in a series of patients by Appelbaum, at Willard Parker.* Gamma-globulin has subsequently been tried in the treatment of measles encephalitis; however, experience has indicated that it is not an effective therapeutic agent.6The purpose of this presentation is to summarize the experience over a 10-year period with measles meningoencephalitis occurring in the pediatric age group at Grasslands Hospital. There have been 24 diagnosed cases of measles meningoencephalitis treated here since 1945, References 1. Ford, F. R.: Diseases of the Nervous System in Infancy , Childhood and Adolescence , Ed. 3, Springfield, Ill., Charles C Thomas, Publisher, 1952. 2. Malamud, N.: Sequelae of Postmeasles Encephalomyelitis: A Clinicopthologic Study , Arch. Neurol. & Psychiat. 41:943-954 ( (May) ) 1939. 3. Gesell, A.: Growth and Development: Trends Toward a Clinical Science of Child Development , in the 1950 Year Book of Pediatrics (July, 1949-July, 1950) , edited by H. G. Poncher, Chicago, The Year Book Publishers, Inc., 1950, p. 371. 4. Neal, J. B., and Appelbaum, E.: Encephalitis Associated with Measles , J.A.M.A. 88:1552-1554 ( (May 14) ) 1927. 5. Solomons, G.; Markman, C. A., and West, E. J.: Measles Encephalitis , Pediatrics 11:473-478 ( (May) ) 1953. 6. Greenberg, M.; Appelbaum, E.; Pellitteri, O., and Eisenstein, D. T.: Measles Encephalitis: II. Treatment with Gamma Globulin , J. Pediat. 46:648-653 ( (June) ) 1955. 7. Musser, J. H., and Hauser, G. H.: Encephalitis as a Complication of Measles , J. A. M. A. 90:1267-1270 ( (April 21) ) 1928. 8. Allen, J. E., and Frank, D. J.: The Use of Gamma Globulin in the Treatment of Measles Encephalitis , Pediatrics 17:78-83 ( (Jan.) ) 1956.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1956

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