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Erythrocytes and Hemoglobin of the Blood in Infancy and Childhood: III. Factors in Variability, Statistical Studies

Erythrocytes and Hemoglobin of the Blood in Infancy and Childhood: III. Factors in Variability,... Abstract This paper presents a summary of hematologic data collected during the years 1932 to 1942. Some have been published previously in reports dealing particularly with problems of iron-deficiency anemia.1-5 At the time the studies were done plans were made for more complete statistical analysis of the assembled data, but various circumstances delayed the completion of that part of the project. The data are now presented in tables and charts designed to emphasize the sequence of changes in characteristics of the erythrocytes of infants and children at different ages and to demonstrate certain patterns of variability in those characteristics observed within different age groups. The data were derived from studies on 1735 samples of blood from infants and children selected at random, at ages from birth to 16 years. Of these, 1568 samples were from children born at full term, of single birth, and 167 samples were from twins, triplets, References 1. Guest, G. M., and Brown, E. W.: Erythrocytes and Hemoglobin of the Blood in Infancy and in Childhood: I. Size and Hemoglobin Content of the Erythrocytes in Nutritional Anemia , Am. J. Dis. Child. 52:616-626 ( (Sept.) ) 1936.Crossref 2. Guest, G. M.; Brown, E. W., and Wing, M.: Erythrocytes and Hemoglobin of the Blood in Infancy and Childhood: II. Variability in Number, Size and Hemoglobin Content of the Erythrocytes During the First 5 Years of Life , Am. J. Dis. Child. 56:529-549 ( (Sept.) ) 1938.Crossref 3. Guest, G. M.: Hematologic Methods in Detecting Nutritional Anemia , in Nutrition: The Newer Diagnostic Methods , New York, Milbank Memorial Fund, 1938. 4. Guest, G. M.: Variabilité dans le nombre, le volume moyen et la concentration en hémoglobine des globules rouges, ainsi que dans l'hémoglobine totale du sang, pendent la période comprise entre la naissance et la cinquième année , Xe Cong. d. Pediat. Paris , Oct. 6, 7, 8, 1938, pp. 111-121. 5. Guest, G. M.: Hypoferric Anemia in Infancy: Nutritional Anemia , Robert Gould Research Foundation (1947) , 1:144-163 ( (Aug.) ) 1948. 6. Lahey, M. E., personal communication to the authors. 7. Guest, G. M., and Siler, V. E.: Centrifuge Method for the Determination of the Volume of Cells in Blood , J. Lab. & Clin. Med. 19:757-767 ( (April) ) 1934. 8. Palmer, W. W.: The Colorimetric Determination of Hemoglobin , J. Biol. Chem. 33:119 ( (Jan.) ) 1918. 9. Van Slyke, D. D., and Hiller, A.: Gasometric determination of hemoglobin by the Carbon Monoxide Capacity Method , J. Biol. Chem. 78: 807-819 ( (Aug.) ) 1928. 10. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1946, Chap. 7 . 11. Fisher, R. A.: Statistical Methods for Research Workers , London, Oliver & Boyd, Ltd., 1954, Section 15. 12. Anderson, N. A.; Brown, E. W., and Lyon, R. A.: Causes of Prematurity: II. Comparison of Maternal Histories of Premature and of Full Term Infants , Am. J. Dis. Child. 61:72-87 ( (Jan.) ) 1941. 13. Josephs, H. W.: Iron Metabolism and Hypochromic Anemia of Infancy , Medicine 32: 125-213 ( (May) ) 1953. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Erythrocytes and Hemoglobin of the Blood in Infancy and Childhood: III. Factors in Variability, Statistical Studies

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References (14)

Publisher
American Medical Association
Copyright
Copyright © 1957 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1957.02060040488002
Publisher site
See Article on Publisher Site

Abstract

Abstract This paper presents a summary of hematologic data collected during the years 1932 to 1942. Some have been published previously in reports dealing particularly with problems of iron-deficiency anemia.1-5 At the time the studies were done plans were made for more complete statistical analysis of the assembled data, but various circumstances delayed the completion of that part of the project. The data are now presented in tables and charts designed to emphasize the sequence of changes in characteristics of the erythrocytes of infants and children at different ages and to demonstrate certain patterns of variability in those characteristics observed within different age groups. The data were derived from studies on 1735 samples of blood from infants and children selected at random, at ages from birth to 16 years. Of these, 1568 samples were from children born at full term, of single birth, and 167 samples were from twins, triplets, References 1. Guest, G. M., and Brown, E. W.: Erythrocytes and Hemoglobin of the Blood in Infancy and in Childhood: I. Size and Hemoglobin Content of the Erythrocytes in Nutritional Anemia , Am. J. Dis. Child. 52:616-626 ( (Sept.) ) 1936.Crossref 2. Guest, G. M.; Brown, E. W., and Wing, M.: Erythrocytes and Hemoglobin of the Blood in Infancy and Childhood: II. Variability in Number, Size and Hemoglobin Content of the Erythrocytes During the First 5 Years of Life , Am. J. Dis. Child. 56:529-549 ( (Sept.) ) 1938.Crossref 3. Guest, G. M.: Hematologic Methods in Detecting Nutritional Anemia , in Nutrition: The Newer Diagnostic Methods , New York, Milbank Memorial Fund, 1938. 4. Guest, G. M.: Variabilité dans le nombre, le volume moyen et la concentration en hémoglobine des globules rouges, ainsi que dans l'hémoglobine totale du sang, pendent la période comprise entre la naissance et la cinquième année , Xe Cong. d. Pediat. Paris , Oct. 6, 7, 8, 1938, pp. 111-121. 5. Guest, G. M.: Hypoferric Anemia in Infancy: Nutritional Anemia , Robert Gould Research Foundation (1947) , 1:144-163 ( (Aug.) ) 1948. 6. Lahey, M. E., personal communication to the authors. 7. Guest, G. M., and Siler, V. E.: Centrifuge Method for the Determination of the Volume of Cells in Blood , J. Lab. & Clin. Med. 19:757-767 ( (April) ) 1934. 8. Palmer, W. W.: The Colorimetric Determination of Hemoglobin , J. Biol. Chem. 33:119 ( (Jan.) ) 1918. 9. Van Slyke, D. D., and Hiller, A.: Gasometric determination of hemoglobin by the Carbon Monoxide Capacity Method , J. Biol. Chem. 78: 807-819 ( (Aug.) ) 1928. 10. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1946, Chap. 7 . 11. Fisher, R. A.: Statistical Methods for Research Workers , London, Oliver & Boyd, Ltd., 1954, Section 15. 12. Anderson, N. A.; Brown, E. W., and Lyon, R. A.: Causes of Prematurity: II. Comparison of Maternal Histories of Premature and of Full Term Infants , Am. J. Dis. Child. 61:72-87 ( (Jan.) ) 1941. 13. Josephs, H. W.: Iron Metabolism and Hypochromic Anemia of Infancy , Medicine 32: 125-213 ( (May) ) 1953.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1957

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