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Clinical Study of Oral Phenoxymethyl Penicillin and Parenteral Procaine Penicillin G: Comparative Study of Results in 1266 Children

Clinical Study of Oral Phenoxymethyl Penicillin and Parenteral Procaine Penicillin G: Comparative... Abstract The recent introduction to clinical medicine of phenoxymethyl penicillin (penicillin V) has for the first time provided a penicillin which is virtually insoluble and therefore stable in the pH range of gastric juice. In the alkaline media of the intestines this preparation is soluble and therefore readily absorbed. Reports indicate that orally administered phenoxymethyl penicillin produces blood concentrations considerably higher than a comparable dose of penicillin G. Following oral administration of phenoxymethyl twice as much penicillin is excreted in the urine in an active form as following oral administration of penicillin G. The activity of phenoxymethyl penicillin is similar to that of penicillin G. However, penicillin blood levels attained with the orally administered phenoxymethyl penicillin preparation are lower and less uniform than blood levels from equal doses of crystalline penicillin G given parenterally.3 The blood levels attained with orally administered phenoxymethyl penicillin are superior to levels obtained from comparable References 1. Brandi, E.; Giovannini, M., and Margreiter, H.: Untersuchungen über das säurestabile, oral wirksame Phenoxymethyl-Penicillin (Penicillin V) , Wien. med. Wchnschr. 103:602-607, 1953. 2. Wright, W. W.; Kirshbaum, A.; Arret, B.; Putnam, L. E., and Welch, H.: Serum Concentrations and Urinary Excretion Following Oral Administration of Penicillin V and Comparison with Penicillin G , Antibiotic Med. 1:490-495, 1955. 3. Nichols, R. L.; Jones, W. F., and Finland, M.: Plasma Penicillin Levels from Oral Penicillin V and G and Intramuscular Penicillin G , Proc. Soc. Exper. Biol. & Med. 90:688-692, 1955. 4. Santos-Buch, C. A.; Koenig, M. G., and Rogers, D. E.: Oral Treatment of Subacute Bacterial Endocarditis with Phenoxymethyl Penicillin , New England J. Med. 257:249-257, 1957. 5. Smith, C. I.; Levin, J. D., and Embody, D. R.: Studies on the Binding of Penicillins G and V by Human Plasma , Antibiotics Ann. pp. 306-310, 1956-1957. 6. Wright, W. W.; Putman, L. E., and Welch, H.: Antibiotics and Chemother., to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Clinical Study of Oral Phenoxymethyl Penicillin and Parenteral Procaine Penicillin G: Comparative Study of Results in 1266 Children

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1958.02060060181008
Publisher site
See Article on Publisher Site

Abstract

Abstract The recent introduction to clinical medicine of phenoxymethyl penicillin (penicillin V) has for the first time provided a penicillin which is virtually insoluble and therefore stable in the pH range of gastric juice. In the alkaline media of the intestines this preparation is soluble and therefore readily absorbed. Reports indicate that orally administered phenoxymethyl penicillin produces blood concentrations considerably higher than a comparable dose of penicillin G. Following oral administration of phenoxymethyl twice as much penicillin is excreted in the urine in an active form as following oral administration of penicillin G. The activity of phenoxymethyl penicillin is similar to that of penicillin G. However, penicillin blood levels attained with the orally administered phenoxymethyl penicillin preparation are lower and less uniform than blood levels from equal doses of crystalline penicillin G given parenterally.3 The blood levels attained with orally administered phenoxymethyl penicillin are superior to levels obtained from comparable References 1. Brandi, E.; Giovannini, M., and Margreiter, H.: Untersuchungen über das säurestabile, oral wirksame Phenoxymethyl-Penicillin (Penicillin V) , Wien. med. Wchnschr. 103:602-607, 1953. 2. Wright, W. W.; Kirshbaum, A.; Arret, B.; Putnam, L. E., and Welch, H.: Serum Concentrations and Urinary Excretion Following Oral Administration of Penicillin V and Comparison with Penicillin G , Antibiotic Med. 1:490-495, 1955. 3. Nichols, R. L.; Jones, W. F., and Finland, M.: Plasma Penicillin Levels from Oral Penicillin V and G and Intramuscular Penicillin G , Proc. Soc. Exper. Biol. & Med. 90:688-692, 1955. 4. Santos-Buch, C. A.; Koenig, M. G., and Rogers, D. E.: Oral Treatment of Subacute Bacterial Endocarditis with Phenoxymethyl Penicillin , New England J. Med. 257:249-257, 1957. 5. Smith, C. I.; Levin, J. D., and Embody, D. R.: Studies on the Binding of Penicillins G and V by Human Plasma , Antibiotics Ann. pp. 306-310, 1956-1957. 6. Wright, W. W.; Putman, L. E., and Welch, H.: Antibiotics and Chemother., to be published.

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1958

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