Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Anaphylactoid Purpura in Children (Schönlein-Henoch Syndrome): Review with a Follow-Up of the Renal Complications

Anaphylactoid Purpura in Children (Schönlein-Henoch Syndrome): Review with a Follow-Up of the... Abstract Introduction Over 150 years have passed since Heberden1 and Willan2 first described patients with peculiar visceral crises associated with purpura and edema of the feet and hands. This striking syndrome has interested many investigators. Schönlein3 described the arthritic component associated with purpura in 1837, calling it "peliosis rheumatica"; Henoch4 added his classic description of four children with skin lesions associated with colicky abdominal pain, gastrointestinal hemorrhage, and joint pain in 1874; and Osler,5-8 in a series of articles between 1895 and 1914 characterized it as a disease entity with variable symptoms, all of which he felt were the result of anaphylaxis. The term "anaphylactoid" purpura was first used by Frank9 in 1915, and this idea was developed further by Glanzmann10 in 1920.Sixty years ago, Henoch11 noted that renal involvement was an important part of this type of purpura, and several years References 1. Heberden, W., cited by Rook, A.: William Heberden's Cases of Anaphylactoid Purpura , Arch. Dis. Childhood 33:271, 1958.Crossref 2. Willan, R.: On Cutaneous Diseases , London, J. Johnson, 1808. 3. Schönlein, J. L.: Allgemeine und specielle Pathologie und Therapie , Ed. 3, Herisau, Lit.-Compt., 1837, Vol. 2, p. 48. 4. Henoch, E.: Über eine eigenthümliche Form von Purpura , Berl. klin. Wchnschr. 11:641, 1874. 5. Osler, W.: The Visceral Complications of Erythema Exudativium Multiforme , Am. J.M. Sc. 110:629, 1895.Crossref 6. Osler, W.: Visceral Lesions of the Erythema Group , Brit. J. Dermat. 12:227, 1900. 7. Osler, W.: Visceral Manifestations of the Erythema Group of Skin Diseases , Am. J.M. Sc. 127:1, 1904.Crossref 8. Osler, W.: Visceral Lesions of Purpura and Allied Conditions , Brit. M.J. 1:517, 1914.Crossref 9. Frank, E.: Die essentielle Thrombopenie , Berl. Klin. Wchnschr. 52:454, 1915. 10. Glanzmann, E.: Die Konzeption der Anaphylaktoiden Purpura , Jahrb. p. Kinderh. 91:391, 1920. 11. Henoch, E.: Vorlesungen über Kinderkrankheiten , Ed. 10. Berlin, A. Hirschwald, 1899, p. 839. 12. Gairdner, D.: The Schönlein-Henoch Syndrome (Anaphylactoid Purpura) , Quart. J. Med. 17:95, 1948. 13. Philpott, M. G.: The Schönlein-Henoch Syndrome in Childhood with Particular Reference to the Occurrence of Nephritis , Arch. Dis. Childhood 27:480, 1952.Crossref 14. Levitt, L. M., and Burbank, B.: Glomerulonephritis as a Complication of Schönlein-Henoch Syndrome , New England J. Med. 248:530, 1953.Crossref 15. Simpkiss, M. J.: The Henoch-Schönlein Syndrome . Great Ormand St. J. 5:7, 1953. 16. Wedgewood, R. J. P., and Klaus, M. H.: Anaphylactoid Purpura: A Long Term Follow-Up Study with Special Reference to Renal Involvement , Pediatrics 16:196, 1955. 17. Derham, R. J., and Rogerson, M. M.: The Schönlein-Henoch Syndrome with Particular Reference to Renal Sequelae , Arch. Dis. Childhood 31:364, 1956.Crossref 18. Oliver, T. K., Jr., and Barnett, H. L.: Incidence and Prognosis of Nephritis Associated with Anaphylactoid (Schönlein-Henoch) Purpura in Children , A.M.A. Am. J. Dis. Child. 90:544, 1955. 19. Davis, E.: Schönlein-Henoch Syndrome of Vascular Purpura , Blood 3:129, 1948. 20. Bywaters, E. G. L.; Isdale, I., and Kempton, J. J.: Schönlein-Henoch Purpura , Quart. J. Med. 26:161, 1957. 21. Lewis, I. C.: Schönlein-Henoch Syndrome (Anaphylactoid Purpura) Compared with Certain Features of Nephritis and Rheumatism , Arch. Dis. Childhood 30:212, J 1955.Crossref 22. Glaser, J.: Allergy in Childhood , Springfield, Ill., Charles C Thomas, Publisher, 1956. 23. Alexander, H. L., and Eyermann, C. H.: Food Allergy in Henoch's Purpura , Arch. Dermat. & Syph. 16:322, 1927. 24. Kuhn, I. S.: Allergic Purpura , J. Lab. & Clin. Med. 14:835, 1929. 25. Barthelme, L. L.: Allergic Purpura , J. Allergy 1:170, 1930.Crossref 26. Diamond, J.: Anaphylactoid or Allergic Purpura , J. Pediat. 8:697, 1936.Crossref 27. Hampton, S. F.: Henoch's Purpura Based on Food Allergy: Report of 2 Cases , J. Allergy 12:579, 1941.Crossref 28. Piraino, A. F.: Schönlein-Henoch Syndrome , Ann. Allergy 11:332, 1953. 29. Creger, W. P., and Houseworth, J. H.: Erythrophagocytosis and Thrombocytopathy Occurring During the Course of a Henoch-Schönlein Syndrome Due to Quinine , Am. J. Med. 17:423, 1954.Crossref 30. Burke, D. M., and Jellinek, H. L.: Nearly Fatal Case of Schönlein-Henoch Syndrome Following Insect Bite , A.M.A. Am. J. Dis. Child. 88: 772, 1954. 31. Siegel, J. M.; Brown, H. E., and DiLeo, L. W.: Purpura as a Result of Insect Allergy: Treatment with Cortisone , Postgrad. Med. 15:46, 1954. 32. Herhaus, B.: Schönlein-Henoch Purpura nach Conteben , Deutsche med. Wchnschr. 80:559, 1955. 33. Casser, L.: Anaphylactoid Purpura Following Penicillin Therapy , J.M. Soc. New Jersey 53: 133, 1956. 34. Carmel, W. J., Jr., and Dannenberg, T.: Nonthrombocytopenic Purpura Due to Miltown , New England J. Med. 255:770, 1956.Crossref 35. Ackroyd, J. F.: Allergic Purpura Including Purpura Due to Foods, Drugs and Infections , Am. J. Med. 14:605, 1953.Crossref 36. Vierhuff, J.: Zur Casuistik der Darminvagination , St. Petersburg med. Wchnschr. 10:369, 1893. 37. Balf, C. L.: The Alimentary Lesion in Anaphylactoid Purpura , Arch. Dis. Childhood 26: 20, 1951.Crossref 38. Sutherland, G. A.: Intussusception and Henoch's Purpura , Brit. J. Child. Dis. 1:23, 1904. 39. Burrows, H.: A Case of Henoch's Purpura in Which a Laparotomy Was Performed , Brit. J. Child. Dis. 1:28, 1904. 40. Lett, H.: Henoch's Purpura and Intussusception , Lancet 1:534, 1909.Crossref 41. McKechnie, R. E.: The Surgeon's Interest in Henoch's Purpura , Canad. M.A.J. 1:1040, 1911. 42. Wolfsohn, H.: Purpura and Intussusception , Arch. Dis. Childhood 22:242, 1947.Crossref 43. Lewis, I. D., and Philpott, M. G.: Neurological Complications in the Schönlein-Henoch Syndrome , Arch. Dis. Childhood 31:369, 1956.Crossref 44. Vernier, R. L.; Farquhar, M. G.; Brunson, J. G., and Good, R. A.: Chronic Renal Disease in Children , A.M.A.J. Dis. Child. 96:306, 1958.Crossref 45. Miescher, P.; Reymond, A., and Ritter, O.: Le Rôle de l'allergie bactérienne dans la pathogénèse de certaines vasculites , Schweiz. med. Wchnschr. 86:799, 1956. 46. Israel, L.; Mathé, G., and Bernard, J.: Purpura capillaire provoqué chez le cobaye par un immun-sérum de lapin anti-endothélium de cobaye , Sang 26:603, 1955. 47. Israel, L.; Mathé, G., and Bernard, J.: Effets des injections dans le derme du cobaye: I. de sérum de lapin anti-endothélium de cobaye; II. de sérum de malades atteints de purpura rhumatoide et glomérulonéphrite , Sang 26:606, 1955. 48. Israel, L; Mathé, G., and Bernard, J.: Sur le syndrome de Schönlein-Henoch , Rev. franç. clin. biol. 1:57, 1956. 49. Stefanini, M.; Roy, C. A.; Zannos, L., and Dameshek, W.: The Therapeutic Effect of Pituitary Adrenocorticotropic Hormones in a Case of Henoch-Schönlein Vascular (Anaphylactoid) Purpura , J.A.M.A. 144:1372, 1950.Crossref 50. Levinson. J. E.; Horwitz, M.; Kulka, J. P.; Page, L., and Bauer, W.: Schönlein-Henoch Syndrome Response to ACTH: Case with Serial Skin Biopsies , Ann. Rheumat. Dis. 10:255, 1951.Crossref 51. Kugelmass, I. N.: Cortisone in Allergic Purpura of Children , New York J. Med. 51:2504, 1951. 52. Adamson, D. G.; Walker, W., and MacIintosh, A. E.: ACTH and Cortisone in Idiopathic Thrombocytopenic and Schönlein-Henoch (Allergic) Purpura , Brit. M.J. 2:656, 1953.Crossref 53. Leese, W. L. B.: Prolonged Treatment of the Schönlein-Henoch Syndrome with Corticotrophin , Lancet 2:851, 1955.Crossref 54. Stefanini, M., and Martino, N. B.: Use of Prednisone in the Management of Some Hemorrhagic States , New England J. Med. 254:313, 1956.Crossref 55. Cohen, A. S.: Acute Schönlein-Henoch Purpura Treated with Prednisolone , Brit. M.J. 1:143, 1957.Crossref 56. Wooley, E. J. S.: A Case of Schönlein-Henoch Purpura Treated with ACTH , Brit. M.J. 1:259, 1952.Crossref 57. Freeman, A. M.: Recurrent Henoch-Schönlein Purpura , South M.J. 46:609, 1953.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Journal of Diseases of Children American Medical Association

Anaphylactoid Purpura in Children (Schönlein-Henoch Syndrome): Review with a Follow-Up of the Renal Complications

Loading next page...
 
/lp/american-medical-association/anaphylactoid-purpura-in-children-sch-nlein-henoch-syndrome-review-rbIp0Hwgfp
Publisher
American Medical Association
Copyright
Copyright © 1960 American Medical Association. All Rights Reserved.
ISSN
0096-6916
DOI
10.1001/archpedi.1960.02070030835021
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Over 150 years have passed since Heberden1 and Willan2 first described patients with peculiar visceral crises associated with purpura and edema of the feet and hands. This striking syndrome has interested many investigators. Schönlein3 described the arthritic component associated with purpura in 1837, calling it "peliosis rheumatica"; Henoch4 added his classic description of four children with skin lesions associated with colicky abdominal pain, gastrointestinal hemorrhage, and joint pain in 1874; and Osler,5-8 in a series of articles between 1895 and 1914 characterized it as a disease entity with variable symptoms, all of which he felt were the result of anaphylaxis. The term "anaphylactoid" purpura was first used by Frank9 in 1915, and this idea was developed further by Glanzmann10 in 1920.Sixty years ago, Henoch11 noted that renal involvement was an important part of this type of purpura, and several years References 1. Heberden, W., cited by Rook, A.: William Heberden's Cases of Anaphylactoid Purpura , Arch. Dis. Childhood 33:271, 1958.Crossref 2. Willan, R.: On Cutaneous Diseases , London, J. Johnson, 1808. 3. Schönlein, J. L.: Allgemeine und specielle Pathologie und Therapie , Ed. 3, Herisau, Lit.-Compt., 1837, Vol. 2, p. 48. 4. Henoch, E.: Über eine eigenthümliche Form von Purpura , Berl. klin. Wchnschr. 11:641, 1874. 5. Osler, W.: The Visceral Complications of Erythema Exudativium Multiforme , Am. J.M. Sc. 110:629, 1895.Crossref 6. Osler, W.: Visceral Lesions of the Erythema Group , Brit. J. Dermat. 12:227, 1900. 7. Osler, W.: Visceral Manifestations of the Erythema Group of Skin Diseases , Am. J.M. Sc. 127:1, 1904.Crossref 8. Osler, W.: Visceral Lesions of Purpura and Allied Conditions , Brit. M.J. 1:517, 1914.Crossref 9. Frank, E.: Die essentielle Thrombopenie , Berl. Klin. Wchnschr. 52:454, 1915. 10. Glanzmann, E.: Die Konzeption der Anaphylaktoiden Purpura , Jahrb. p. Kinderh. 91:391, 1920. 11. Henoch, E.: Vorlesungen über Kinderkrankheiten , Ed. 10. Berlin, A. Hirschwald, 1899, p. 839. 12. Gairdner, D.: The Schönlein-Henoch Syndrome (Anaphylactoid Purpura) , Quart. J. Med. 17:95, 1948. 13. Philpott, M. G.: The Schönlein-Henoch Syndrome in Childhood with Particular Reference to the Occurrence of Nephritis , Arch. Dis. Childhood 27:480, 1952.Crossref 14. Levitt, L. M., and Burbank, B.: Glomerulonephritis as a Complication of Schönlein-Henoch Syndrome , New England J. Med. 248:530, 1953.Crossref 15. Simpkiss, M. J.: The Henoch-Schönlein Syndrome . Great Ormand St. J. 5:7, 1953. 16. Wedgewood, R. J. P., and Klaus, M. H.: Anaphylactoid Purpura: A Long Term Follow-Up Study with Special Reference to Renal Involvement , Pediatrics 16:196, 1955. 17. Derham, R. J., and Rogerson, M. M.: The Schönlein-Henoch Syndrome with Particular Reference to Renal Sequelae , Arch. Dis. Childhood 31:364, 1956.Crossref 18. Oliver, T. K., Jr., and Barnett, H. L.: Incidence and Prognosis of Nephritis Associated with Anaphylactoid (Schönlein-Henoch) Purpura in Children , A.M.A. Am. J. Dis. Child. 90:544, 1955. 19. Davis, E.: Schönlein-Henoch Syndrome of Vascular Purpura , Blood 3:129, 1948. 20. Bywaters, E. G. L.; Isdale, I., and Kempton, J. J.: Schönlein-Henoch Purpura , Quart. J. Med. 26:161, 1957. 21. Lewis, I. C.: Schönlein-Henoch Syndrome (Anaphylactoid Purpura) Compared with Certain Features of Nephritis and Rheumatism , Arch. Dis. Childhood 30:212, J 1955.Crossref 22. Glaser, J.: Allergy in Childhood , Springfield, Ill., Charles C Thomas, Publisher, 1956. 23. Alexander, H. L., and Eyermann, C. H.: Food Allergy in Henoch's Purpura , Arch. Dermat. & Syph. 16:322, 1927. 24. Kuhn, I. S.: Allergic Purpura , J. Lab. & Clin. Med. 14:835, 1929. 25. Barthelme, L. L.: Allergic Purpura , J. Allergy 1:170, 1930.Crossref 26. Diamond, J.: Anaphylactoid or Allergic Purpura , J. Pediat. 8:697, 1936.Crossref 27. Hampton, S. F.: Henoch's Purpura Based on Food Allergy: Report of 2 Cases , J. Allergy 12:579, 1941.Crossref 28. Piraino, A. F.: Schönlein-Henoch Syndrome , Ann. Allergy 11:332, 1953. 29. Creger, W. P., and Houseworth, J. H.: Erythrophagocytosis and Thrombocytopathy Occurring During the Course of a Henoch-Schönlein Syndrome Due to Quinine , Am. J. Med. 17:423, 1954.Crossref 30. Burke, D. M., and Jellinek, H. L.: Nearly Fatal Case of Schönlein-Henoch Syndrome Following Insect Bite , A.M.A. Am. J. Dis. Child. 88: 772, 1954. 31. Siegel, J. M.; Brown, H. E., and DiLeo, L. W.: Purpura as a Result of Insect Allergy: Treatment with Cortisone , Postgrad. Med. 15:46, 1954. 32. Herhaus, B.: Schönlein-Henoch Purpura nach Conteben , Deutsche med. Wchnschr. 80:559, 1955. 33. Casser, L.: Anaphylactoid Purpura Following Penicillin Therapy , J.M. Soc. New Jersey 53: 133, 1956. 34. Carmel, W. J., Jr., and Dannenberg, T.: Nonthrombocytopenic Purpura Due to Miltown , New England J. Med. 255:770, 1956.Crossref 35. Ackroyd, J. F.: Allergic Purpura Including Purpura Due to Foods, Drugs and Infections , Am. J. Med. 14:605, 1953.Crossref 36. Vierhuff, J.: Zur Casuistik der Darminvagination , St. Petersburg med. Wchnschr. 10:369, 1893. 37. Balf, C. L.: The Alimentary Lesion in Anaphylactoid Purpura , Arch. Dis. Childhood 26: 20, 1951.Crossref 38. Sutherland, G. A.: Intussusception and Henoch's Purpura , Brit. J. Child. Dis. 1:23, 1904. 39. Burrows, H.: A Case of Henoch's Purpura in Which a Laparotomy Was Performed , Brit. J. Child. Dis. 1:28, 1904. 40. Lett, H.: Henoch's Purpura and Intussusception , Lancet 1:534, 1909.Crossref 41. McKechnie, R. E.: The Surgeon's Interest in Henoch's Purpura , Canad. M.A.J. 1:1040, 1911. 42. Wolfsohn, H.: Purpura and Intussusception , Arch. Dis. Childhood 22:242, 1947.Crossref 43. Lewis, I. D., and Philpott, M. G.: Neurological Complications in the Schönlein-Henoch Syndrome , Arch. Dis. Childhood 31:369, 1956.Crossref 44. Vernier, R. L.; Farquhar, M. G.; Brunson, J. G., and Good, R. A.: Chronic Renal Disease in Children , A.M.A.J. Dis. Child. 96:306, 1958.Crossref 45. Miescher, P.; Reymond, A., and Ritter, O.: Le Rôle de l'allergie bactérienne dans la pathogénèse de certaines vasculites , Schweiz. med. Wchnschr. 86:799, 1956. 46. Israel, L.; Mathé, G., and Bernard, J.: Purpura capillaire provoqué chez le cobaye par un immun-sérum de lapin anti-endothélium de cobaye , Sang 26:603, 1955. 47. Israel, L.; Mathé, G., and Bernard, J.: Effets des injections dans le derme du cobaye: I. de sérum de lapin anti-endothélium de cobaye; II. de sérum de malades atteints de purpura rhumatoide et glomérulonéphrite , Sang 26:606, 1955. 48. Israel, L; Mathé, G., and Bernard, J.: Sur le syndrome de Schönlein-Henoch , Rev. franç. clin. biol. 1:57, 1956. 49. Stefanini, M.; Roy, C. A.; Zannos, L., and Dameshek, W.: The Therapeutic Effect of Pituitary Adrenocorticotropic Hormones in a Case of Henoch-Schönlein Vascular (Anaphylactoid) Purpura , J.A.M.A. 144:1372, 1950.Crossref 50. Levinson. J. E.; Horwitz, M.; Kulka, J. P.; Page, L., and Bauer, W.: Schönlein-Henoch Syndrome Response to ACTH: Case with Serial Skin Biopsies , Ann. Rheumat. Dis. 10:255, 1951.Crossref 51. Kugelmass, I. N.: Cortisone in Allergic Purpura of Children , New York J. Med. 51:2504, 1951. 52. Adamson, D. G.; Walker, W., and MacIintosh, A. E.: ACTH and Cortisone in Idiopathic Thrombocytopenic and Schönlein-Henoch (Allergic) Purpura , Brit. M.J. 2:656, 1953.Crossref 53. Leese, W. L. B.: Prolonged Treatment of the Schönlein-Henoch Syndrome with Corticotrophin , Lancet 2:851, 1955.Crossref 54. Stefanini, M., and Martino, N. B.: Use of Prednisone in the Management of Some Hemorrhagic States , New England J. Med. 254:313, 1956.Crossref 55. Cohen, A. S.: Acute Schönlein-Henoch Purpura Treated with Prednisolone , Brit. M.J. 1:143, 1957.Crossref 56. Wooley, E. J. S.: A Case of Schönlein-Henoch Purpura Treated with ACTH , Brit. M.J. 1:259, 1952.Crossref 57. Freeman, A. M.: Recurrent Henoch-Schönlein Purpura , South M.J. 46:609, 1953.Crossref

Journal

A.M.A. Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1960

References