Abstract

Published OnlineFirst February 22, 2021; DOI: 10.1158/1055-9965.EPI-20-1670 CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION | RESEARCH ARTICLE Hysterectomy and Risk of Breast, Colorectal, Thyroid, and Kidney Cancer – an Australian Data Linkage Study 1,2 1,2 1,2 1,3 Louise F. Wilson , Karen M. Tuesley , Penelope M. Webb , Suzanne C. Dixon-Suen , 4,5 1,2 Louise M. Stewart , and Susan J. Jordan ABSTRACT Background: This study aimed to investigate the associations 1.29; 95% CI, 0.96–1.73, respectively). Hysterectomy, but not between hysterectomy for benign indications and risk of breast, hysterectomy-BSO, was related to higher risk of thyroid cancer colorectal, kidney, and thyroid cancer, and to explore whether these (HR, 1.38; 95% CI, 1.19–1.60). In contrast, hysterectomy (HR, 0.94; associations are modified by removal of ovaries at the time of 95% CI, 0.90–0.98) and hysterectomy-BSO (HR, 0.92; 95% CI, 0.85– surgery or by age at surgery. 1.00) were associated with lower risk of breast cancer. We found no Methods: We conducted a retrospective cohort study of the association between hysterectomy status and colorectal cancer. female population of Western Australia (n ¼ 839,332) linking data Conclusions: The associations between hysterectomy and cancer from electoral, hospital, births, deaths, and cancer records. We used varied