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THE ULTRASTRUCTURE OF THE PARASITOPHOROUS VACUOLE FORMED BY LEISHMANIA MAJOR

THE ULTRASTRUCTURE OF THE PARASITOPHOROUS VACUOLE FORMED BY LEISHMANIA MAJOR Protozoan parasites of Leishmania spp. invade macrophages as promastigotes and differentiate into replicative amastigotes within parasitophorous vacuoles. Infection of inbred strains of mice with Leishmania major is a well-studied model of the mammalian immune response to Leishmania species, but the ultrastructure and biochemical properties of the parasitophorous vacuole occupied by this parasite have been best characterized for other species of Leishmania . We examined the parasitophorous vacuole occupied by L. major in lymph nodes of infected mice and in bone marrow–derived macrophages infected in vitro. At all time points after infection, single L. major amastigotes were wrapped tightly by host membrane, suggesting that amastigotes segregate into separate vacuoles during replication. This small, individual vacuole contrasts sharply with the large, communal vacuoles occupied by Leishmania amazonensis . An extensive survey of the literature revealed that the single vacuoles occupied by L. major are characteristic of those formed by Old World species of Leishmania , while New World species of Leishmania form large vacuoles occupied by many amastigotes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Parasitology Allen Press

THE ULTRASTRUCTURE OF THE PARASITOPHOROUS VACUOLE FORMED BY LEISHMANIA MAJOR

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References (48)

Publisher
Allen Press
Copyright
American Society of Parasitologists
Subject
DEVELOPMENT
ISSN
0022-3395
eISSN
1937-2345
DOI
10.1645/GE-841R.1
pmid
17304790
Publisher site
See Article on Publisher Site

Abstract

Protozoan parasites of Leishmania spp. invade macrophages as promastigotes and differentiate into replicative amastigotes within parasitophorous vacuoles. Infection of inbred strains of mice with Leishmania major is a well-studied model of the mammalian immune response to Leishmania species, but the ultrastructure and biochemical properties of the parasitophorous vacuole occupied by this parasite have been best characterized for other species of Leishmania . We examined the parasitophorous vacuole occupied by L. major in lymph nodes of infected mice and in bone marrow–derived macrophages infected in vitro. At all time points after infection, single L. major amastigotes were wrapped tightly by host membrane, suggesting that amastigotes segregate into separate vacuoles during replication. This small, individual vacuole contrasts sharply with the large, communal vacuoles occupied by Leishmania amazonensis . An extensive survey of the literature revealed that the single vacuoles occupied by L. major are characteristic of those formed by Old World species of Leishmania , while New World species of Leishmania form large vacuoles occupied by many amastigotes.

Journal

Journal of ParasitologyAllen Press

Published: Dec 1, 2006

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